Guaianolides from Chrysophthalmum montanum(DC.) Boiss

The small genus Chrysophthalmum (tribe Inuleae) with four species, distributed over South-East T&uuml;rkiye and Iran. While the chemistry of many genera of Inuleae group has been studied nothing is known about that of Chrysophthalmum. Different types of sesquiterpene lactones; guaianolides, eudesmanolides, germacranes, pseudo-guaianolides have been reported from Inula species which is the most close genus to Chrysophytalmum. Noteworthy, some of these sesquiterpene lactones showed cytotoxic, antibacterial, immunmodulatory and anti-inflammatory activities. In the course of a search for cytotoxic sesquiterpenes in the Asteraceae, we have examined C. montanum a plant on which extensive phytochemical studies have not been previously conducted and isolated four new [2-O-&beta;-D-glucopyranoside-4&alpha;- hydroxy-guai-1(10)-en-12-8&beta;-olide (1), 2-O-(6&prime;-trans-caffeoyl)-&beta;-D-glucopyranoside-4&alpha;-hydroxy-guai-1(10)-en-12-8&beta;- olide (2), 4-O-&beta;-D-glucopyra-noside-10&beta;-hydroxy-guai-1 (2)-en-12-8&beta;-olide (3) and 4-O-&beta;-D-glucopyranoside-10&beta;- hydroxy-guai-12-8&beta;-olide (4)] and three known [2-Deoxypleniradin, 2-Deoxy-6-acetoxy-pleniradin, 4&beta;, 10&alpha;- Dihydroxy-5&alpha;H-guai-1(2), 11(13)-dien-12,8&alpha;-olide] guaianolide type sesquiterpene lactones, along with the three methoxylated flavonoids and chlorogenic acid. The structures of these compounds were elucidated using spectroscopic methods (UV, IR, 1H-NMR, 13C-NMR, 2D-NMR and MS). We would like to thank TUBITAK (Grant No: 112S553) and Research foundation of Erciyes University (TCD-2012-4006) for financially supporting this project.</p

Systematic Review, Meta-analysis and Meta-regression of Epidemiological Studies for Cardiovascular Risk Factors conducted in Turkey: Obesity Data

Objective: Obesity is the most important epidemic of the 21st century and its incidence is increasing steadily in Turkey. The aim of this study was to assess the current status and temporal change in the prevalence of obesity in Turkey with a systematic review and meta-analysis of epidemiological studies conducted in the last 15 years