Early Seizures After Stroke: Neurology Intensive Care Unit Experience

Objective: The aim of this study was to investigate the frequency of early seizures, the affecting factors, and the prognostic effect of seizures in patients with acute ischemic stroke (AIS), intracerebral hemorrhage (ICH), and sinus venous thrombosis (SVT) examined in the intensive care unit (ICU). Materials and Methods: In the neurology ICU, the records of patients followed up with AIS, ICH, and SVT within a defined time period were retrospectively examined. Results: Early seizures occurred in 48 out of 199 patients who were followed up with AIS, ICH, and SVT in the neurology ICU within the specified time period. The frequency of having early seizures was found to be higher in patients with left hemisphere lesions, cortical lesions, and those with AIS with hemorrhagic transformation. Lesion volume was found to be higher in patients with AIS who had early seizures compared with those who had AIS without seizures. Early seizures were observed in all patients with SVT who were followed up in the ICU. Conclusion: Early seizures are a common complication in patients with stroke followed up in neurology ICUs. Determination of effective factors in early seizures is important for its early diagnosis and treatmen

Evaluation of Dynamic Thiol-Disulphide Homeostasis in Patients with Epilepsy

Objectives:The aim of this study was to investigate dynamic thiol-disulphide homeostasis as a novel oxidative stress parameter in patients with epilepsy.Methods:A total of 100 participants were included in the study. Of these, 50 participants were diagnosed with epilepsy and remaining 50 were healthy individuals. Total thiol (–SH+–S-S–) and native thiol (–SH) levels in serum were measured in all patients. Quantity of dynamic disulphide bond and (–S-S–) x 100 / (-SH), (–S-S-) x 100 / (–SH+–S-S–), and –SH x100 / (–SH+–S-S–) ratios were calculated from these values. Data obtained were compared between patients with epilepsy and healthy individuals.Results:No statically significant difference was determined between patients with epilepsy and healthy individuals in terms of total thiol, native thiol, and dynamic disulphide bond levels and (–S-S–) x 100 / (-SH), (–S-S-) x 100 / (–SH+–S-S–), and –SH x 100 / (–SH+–S-S–) ratios. Neither was there significant correlation between total thiol, native thiol, and dynamic disulphide bond levels and (–S-S–), (–S-S–) x 100 / (-SH), (–S-S-) x 100 / (–SH+–S-S–) and –SH x 100 / (–SH+–S-S–) ratios of patients and seizure frequency or duration of illness.Conclusion:Oxidative stress is considered to be one of the molecular changes that are the underlying causes of epileptogenesis. In this study, we investigated dynamic thiol-disulfide homeostasis in patients with epilepsy using a new method in the literature

The Evaluation of Migraine Frequency in Patients with Psoriasis

Aim: Psoriasis, previously thought to be a disease restricted to the skin, is now considered systemic, accompanied by numerous comorbidities. Our study aimed to establish the migraine frequency in psoriasis patients and assess the relationship between the severity and duration of psoriasis and the frequency and severity of migraine. Material and Method: This case-control study was performed in the dermatology outpatient clinic. A total of 80 people, including 40 patients over the age of 18 who applied to the outpatient clinic and were diagnosed with psoriasis, and 40 people with similar gender and age characteristics and other skin problems, were included in the control group. Results: The frequency of migraine in psoriasis patients was 35.0% and 15.0% in the control group. In psoriasis patients, the median Psoriasis Area and Severity Index (PASI) score was 3.60 (1.20–13.20) in patients without migraine and 2.90 (1.20–12.00) in patients with migraine. Migraine frequency was 45.0% in patients suffering from the disease for more than eight years and 25.0% in patients suffering for eight years or less. The incidence of migraine was significantly higher in patients with psoriasis for more than eight years than in the control group. Conclusion: Our study presented important outputs that the severity and duration of psoriasis disease might be related to migraine disease