Current Challenges And Solution Approaches In Empirical Engineering Design Research – A Workshop For Empirical Research

The requirements on validity for studies in design research are very high. Therefore, this paper aims at identifying challenges that occur when setting up studies and suggests solution strategies to address them. Three different institutes combining their experience discussed several studies in a workshop. Resulting main challenges are to find a suitable task, to operationalise the variables and to deal with a high analysis effort per participant. Automation in data evaluation and a detailed practical guideline on studies in design research are considered necessary

Frequency Of Lymphadenopathy In Rheumatoid Arthritis And Systemic Lupus Erythematosus

Scopu

The Effects of dioctyl adipate (DOA) on the liver histology of Labidochromis caeruleus Fryer, 1956 (Cichlidae, Teleostei) [Dioktil adipat'i{dotless}n (doa) Labidochromis caeruleus Fryer, 1956 (Cichlidae, Teleostei) karaciger histolojisi üzerindeki etkileri]

Although dioctyl adipate (DOA, C22H42O4) is one of the most common plasticizers that are used for polymerization, the ecotoxicological effects of it is not well known. From this point of view, aim of this preliminary investigation was to analyze the histopathological changes in the liver of Labidochromis caeruleus (yellow princess), exposed to 0.75 ppm DOA for 30 days. When compared to controls, the most prominent changes occurred in the DOA exposed group were noted as a significant steatosis (fat deposisiton), fibrosis and expanding necrotic areas. The dilatation of sinusoids and central veins, poikilocytosis, and hemorrhage were also observed. The data presented in this study shows that, DOA is a hepatotoxic chemical at least for Labidocromis caerulous

The management of gout in different clinical specialties in Turkey: a patient-based survey

Although gout is potentially curable, the management of this disease is often suboptimal. In this study, we investigated the treatment of gout in Turkey and also compared the management approaches to gout in different clinical specialties. Three hundred and nineteen consecutive patients (mean age 58.60 ± 12.8 years; 44 females, 275 males) were included in this multicenter study. A standardized form was generated to collect data about the patient’s first admission to health care, the specialty of the doctor first diagnosed the gout, the treatment options for gout including attack management, patient referral, chronic treatment including medical treatment, and life style modifications. Forty patients were referred to another center without any treatment (12.8 %), and referral rate is most common among the primary care physicians (28.8 %). Colchicine was more commonly used for attack prophylaxis than allopurinol. Ninety-two patients had never been treated with allopurinol (28.8 %). Allopurinol prescription was less common among the primary care physicians and orthopedists, and highest among the rheumatologists. Recommendation of diet and life style modifications was less common among the primary care physicians and orthopedists, and highest among the rheumatologists. The rates of life style modification recommendation and long-term allopurinol prescription were 83.7 and 77.6 %, respectively, among the rheumatologists. Both acute and chronic management of gout is suboptimal in Turkey especially among the primary care physicians and orthopedists. Moreover, chronic treatment is even suboptimal among rheumatologists. © 2016, International League of Associations for Rheumatology (ILAR)