Spacetime curvature is important for cosmology constrained with supernova emissions

We investigate universe expansion models as functions of emission frequency ratio decline rather than redshift z, using the latest on-line, self-consistent data from 192 supernovae. We present results for simpler and some current models of cosmology, including those with dark energy (standard model) and a recent model correcting for the effect of a small time-dependent, emission frequency increase with lookback. This new model, with a gentle lookback decline of the Planck constant, and the standard model fit the data with similar confidence according to Bayesian Information Criteria. The standard model tends towards solutions high in matter density while remaining flat, but models without dark energy tend towards dilute universes with significant spacetime and curvature and a smaller Hubble constant. We conclude the normalized spacetime parameter, Ω k , should not be ignored and it includes the combined contributions of huge spacetime magnitude and curvature.Validerad; 2008; 20080613 (ysko)</p

Constraints on dark energy and dark matter from supernovae and gamma ray burst data

Godkänd; 2010; 20090914 (ysko)</p

A Novel Missense Mutation in CYLD in a Family with Brooke–Spiegler Syndrome

Brooke–Spiegler syndrome (BSS, familial cylindromatosis or turban tumor syndrome) is an inherited disease characterized by neoplasms of the skin appendages such as cylindroma, trichoepithelioma, and spiradenoma. The disease has been mapped to 16q12-13, and mutations in the CYLD gene have been identified in families with this disorder. Of interest, multiple familial trichoepithelioma (MFT) has been described as a distinct disorder characterized by the familial occurrence of trichoepitheliomas. MFT has been mapped to 9p21; however, to date a candidate gene has not been identified. In this report, we describe a four-generation family with BSS presenting predominantly with trichoepitheliomas (resembling MFT phenotype). We identified a novel missense mutation in the CYLD gene, designated E474G, in the affected individuals of this family. Our findings exemplify clinical heterogeneity within BSS and extend the body of evidence that mutations in CYLD are implicated in this disease. Although not conclusive, these findings suggest that BSS and MFT may represent a single entity