Drug-Induced Acneiform Eruptions

Acne vulgaris is a chronic skin disease that develops as a result of inflammation of the pilosebaceous unit and its clinical course is accompanied by comedones, papules, pustules, and nodules. A different group of disease, which is clinically similar to acne vulgaris but with a different etiopathogenesis, is called “acneiform eruptions.” In clinical practice, acneiform eruptions are generally the answer of the question “What is it if it is not an acne?” Although there are many subgroups of acneiform eruptions, drugs are common cause of acneiform eruptions, and this clinical picture is called “drug-induced acneiform eruptions.” There are many drugs related to drug-induced acneiform eruptions. Discontinuation of the responsible drug is generally sufficient in treatment

Behçet disease: New developments in the etiopathogenesis of an old silk road disease

PubMed ID: 29989537Behçet disease (BD) is a systemic inflammatory disorder that affects the skin, mucosa, eyes, joints, blood vessels, brain, and gastrointestinal tract. The etiopathogenesis of BD has not yet been fully elucidated, but disorganized immune responses against the stimuli of environmental triggering factors have been considered to play a major role in the pathogenesis of the disease in individuals with genetic susceptibility. Human leukocyte antigen (HLA)-B*51 is known to be the main factor involved in genetic susceptibility to BD. Among the environmental factors, infectious agents in particular are thought to be important. Immunological abnormalities could thus be the cornerstone in the development of BD. Along with cytokines that play a role in disease pathogenesis, numerous other cytokines have been recently identified or have been the focus of recent studies. This contribution sheds light on the etiopathogenesis and immunology of BD in relation to the current literature. © 2018 Pulse Marketing & Communications, LLC

The Significance of Scars: Patient and Clinician Perspectives

The formation of a scar represents the extension of regenerative wound repair mechanisms. On the one hand, scar tissue helps in wound closure by supporting wound contracture and reepithelization. There is no doubt that the scar formation developed in response to an injury facilitates the organism’s survival process directly and effectively. On the other hand, the effect of the pathologically developed scarring on the global disease burden has still not been accurately defined. There are three basic subtypes of scars, namely simple, atrophic, and hypertrophic/pathological (hypertrophic scars and keloids), and they have different histopathological features, development, dispersion patterns, and remission phases. There are important consequences when scars’ global and individual effects are considered. Patients with scars face long-term functional and psychological problems. In interpreting scars for both individuals and society, individual, cultural, psychological, and social effects and prejudices play a crucial role. Both the psychosocial and financial aspects of the scars, as well as the effects on the patient and society, should be considered. © 2019 by Nova Science Publishers, Inc

Cutaneous manifestations of diabetes mellitus and the metabolic syndrome

WOS: 000419087300014PubMed: 29241758Metabolic diseases are commonly encountered in the Western world. Cutaneous manifestations are common in metabolic disorders, such as diabetes mellitus (DM) and the metabolic syndrome (MetS), and metabolic diseases may manifest with specific skin findings. MetS and DM share a common mechanism in their etiopathogenesis. As a result, the skin findings associated with these two diseases partially overlap. Several skin findings in DM and MetS may be the first clinical features of the disease, and early diagnosis facilitates treatment, thereby helping in preventing long-term complications. In this review, MetS and skin manifestations associated with DM are discussed. (C) 2018 Elsevier Inc. All rights reserved

Recollection & traumatic growth: unique mediational pathways through traumatic stress components

Although the severity of the COVID-19 outbreak varies from time to time, the pandemic has affected larger audiences worldwide. Given the increasingly severe measures taken by the authorities, healthcare professionals have experienced positive and negative effects of the events, both personally and vicariously. The main aim is to examine how remembering influences vicarious traumatization and post-traumatic growth in a sample of healthcare workers. We proposed a multiple mediation model testing of distinct roles of stress components (hypervigilance, avoidance, intrusion) on the link between recollective features of remembering and post-traumatic growth, which allows characterizing memory-linked mechanisms underlying the effects of traumatic stress on growth. We demonstrated unique pathways by which remembering influenced traumatic growth. For the links of emotional intensity and imagery with growth, we found full mediation through avoidance and intrusion Individuals recalling events with high emotional intensity and imagery tend to experience more intrusions of trauma, which then resulted in traumatic growth. On the other hand, the opposite pattern was found for avoidance. Emotionally intense and vivid recall of events increased avoidance responses, but high avoidance reduced traumatic growth. With respect to reliving, while the pattern was similar, we found a partial mediation, showing the significant role reliving has in supporting traumatic growth.DuolingoEuropean Office of Aerospace Research and DevelopmentFindingFiveMIT-IBM Watson AI LabThe Robert J. Glushko and Pamela Samuelson FoundationToyota Research Institute2-s2.0-85139390184Temmu