Difficulties in the treatment of an Infant with Hemophilia B

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Difficulties in the treatment of an Infant with Hemophilia B

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İdrar ve kan testlerinin üriner enfeksiyon tespitindeki değeri

Amaç: Çocuk hastalarda üriner enfeksiyonun tanısın- da kullanılan idrar ve kan testlerindeki parametrelerin değerlerinin tespiti ve bu parametrelerin bir birleriyle olan ilişkilerinin değerlendirilmesi amaçlanmıştır. Gereç ve Yöntemler: Çalışma popülasyonunu Recep Tayyip Erdoğan Üniversitesi Eğitim ve Araştırma Hastanesi'ne başvuran 0,5-12 yaş arasındaki üriner sistem enfeksiyonu belirtileri olan çocuklar oluştur- muştur. İdrar örnekleri çocukların yaşlarına göre idrar torbası ya da orta akım idrarı şeklinde toplanmıştır. İdrar örneklerinde nitrit, lökosit esteraz, mikroskobik inceleme, idrar kültürü çalışılmıştır. Kan örneklerinde tam kan sayımı ve C-reaktif protein (CRP) çalışılmıştır. Bulgular: Çalışmaya 327 çocuk hasta dahil edilmiştir. Erkek çocukların %45,5'inde kız çocukların %31,4'ünde idrar kültürü pozitif olarak bulunmuştur. Değerlendirilen idrar örneklerinin %30,4'ü kontami- nasyon olarak değerlendirilmiştir. Çalışmada üriner enfeksiyon teşhisinde en hassas test idrar mikrosko- pisi en spesifik test idrar nitrit seviyesi olarak bulun- muştur. Sonuç: Çalışmadan elde edilen bulgulara göre üriner enfeksiyon teşhisinde mikroskobi kültürle birlikte temel test olarak değerlendirilmeli fakat mikroskobi sonuçları diğer testlerle, özelliklede nitritle birlikte değerlendirilmelidir. Çalışmaya göre CRP üriner enfeksiyon teşhisinde iyi bir parametre gibi gözükme- mektedir.Abstract Objective: The goal was to provide a prospective comparison and determine the validity of urine and blood tests for detection of urinary tract infections (UTIs) in young children. Material and Methods: The study population con- sisted of a random sample of children 0.5-12 years of age who presented to the Education and Research Hospital of Recep Tayyip Erdoğan University with symptoms suggesting UTIs. Urine samples were obtained from every child by urinary bag collection or clean catch as appropriate for age. Urine specimens underwent four tests simultaneously: nitrite, leuko- cyte esterase, urinalysis (microscopic), and urine culture. Complete blood count and C-reactive protein (CRP) of participants were tested in blood samples. Results: A total of 327 children were included in the study; 45.5% of boys and 31.4% of girls had a posi- tive urine culture result, and 30.4% of assessed urine samples were evaluated as contamination. Based on the study, the most sensitive test for the diagnosis of UTI was microscopy, and the most specific test for the diagnosis of UTIs was nitrite. Conclusion: According to the findings obtained from the study, microscopy should be considered as a basic test with culture, but the results of microscopy must be supported by other tests, especially nitrite. CRP is unlikely to be a good parameter for the screening of UTIs according to the study

Immune Thrombocytopenic Purpura Secondary to Varicella Zoster Infection: A Case Report

Varicella zoster  infection  is usually considered to be benign despite of serious complications.  Immune Thrombocytopenic Purpura (ITP) is usually a self-limiting disorder in children. ITP is an autoimmune disorder in which antibody-coated or immune complex–coated platelets are destroyed prematurely by the reticuloendothelial system, resulting in peripheral thrombocytopenia.  In primary ITP the thrombocytopenia is isolated, whereas in secondary ITP the condition is associated with other disorders (e.g. Systemic Lupus Erythematous, HIV, VZV). We describe a case of  immune Thrombocytopenic Purpura secondary to varicella infection in a previously healthy 7-y-old boy. He was treated successfully with intravenous immunoglobulin (IVIG)

Peripapillary retinal nerve fiber layer thickness in children with iron deficiency anemia

WOS: 000324918700012PubMed: 23112037PURPOSE. To evaluate peripapillary retinal nerve fiber layer (RNFL) thickness in children with iron deficiency anemia (IDA) in comparison with healthy controls and to investigate the correlation between peripapillary RNFL thicknesses and the hematologic parameters in these subjects. METHODS. Forty eyes of 40 children with a diagnosis of IDA (anemic group) and 40 eyes of 40 age-and sex-matched healthy children (control group) were enrolled in this study. Peripapillary RNFL thickness measurements were performed using Cirrus HD optical coherence tomography (OCT). RESULTS. Mean age of each group was 11.3 +/- 2.7 years. Average RNFL and RNFLs of superior and inferior quadrants were significantly thinner in the anemic group than in the control group (p=0.006, p=0.005, and p=0.005, respectively). in addition, average peripapillary RNFL thickness and RNFL thicknesses of superior, inferior, and temporal quadrants were correlated with hemoglobin levels (r(1)=0.734, p(1)<0.001, r(2)=0.456, p(2)=0.005, r(3)=0.598, p(3)<0.001, r(4)=0.349, p(4)=0.037, respectively) in anemic group. CONCLUSIONS. We found that children with IDA had different peripapillary RNFL profile measured by Cirrus HD spectral-domain OCT. We caution ophthalmologists when they measure RNFL thickness in children to diagnose glaucoma or other neuro-ophthalmic disorders

A rare condition associated with celiac disease: Evans syndrome

Celiac disease (CD) is one of the most common chronic disorders in childhood. Autoimmune and nonauto-immune disorders including dermatitis herpetiformis, type 1 diabetes mellitus, and autoimmune thyroiditis can be encountered associated with CD. Common hematologic manifestations of CD include anemia owing to iron, folate, or vitamin B-12 deficiency. We report a case with CD associated with Evans syndrome of whom to our knowledge, is the first child to be reported in the literature

Turkey Türkiye’nin Doğu Karadeniz bölgesinde ABO ve Rh kan grupları dağılım analizi

Amaç: Bir bölgede kan gruplarının dağılımı hakkında doğru bilgiye sahip olmak, bireylerin ihtiyaçları ve kan bankası işlemleri için yararlı olmasının yanında bilimsel katkı da sağlayacaktır. Bu çalışmada, amacımız Rize ilindeki ABO ve Rh kan gruplarının dağılımını belirlemektir.Gereç ve yöntem: Rize Eğitim ve Araştırma Hastanesi, Kan Merkezine kan grubunun belirlenmesi için başvuran 38,329 kişinin verilerinin retrospektif analizi yapılmıştır. Veri toplama dönemi Ocak 2005-Aralık 2010 tarihleri ara- sındaki beş yılı kapsar. Bulgular: Bizim bulgularımız O, A, B, AB, Rh(+) ve Rh(-) kan grubu sıklıklarının sırasıyla %44.07, %44.07, %9.26, %2.60, %83.70 ve %16.30 olduğunu göstermiştir. Bizim bilgilerimize göre Türkiye’nin Doğu Karadeniz bölgesin- de ABO ve Rh kan gruplarının dağılımı üzerine başka bir çalışma yoktur. Türkiye genelindeki verilerle karşılaştırdı- ğımızda, O kan grubu oranı belirgin olarak yüksek ve B ile AB kan grupları oranları belirgin olarak düşük bulun- muştur. Sonuç: Sonuçlarımızın kan gruplarının dağılımı konu- sunda veri tabanı oluşmasına katkıda bulunacağını dü- şünüyoruz.Objective: Accurate knowledge on the distribution of blood groups in a region is useful for individuals in need and blood bank processes as well as such knowledge would provide scientific contribution. In this study, our ob- jective is to determine ABO and Rh blood groups distribu- tion in the Rize province.Materials and methods: Retrospective analysis has been conducted on the data of 38,329 individuals applied to Blood Center of Rize Training and Research Hospital for blood group determination. The data collection period covers five years, between January 2005 and December 2010. Results: Our findings indicated that the frequencies of the blood groups were as following: Group O 44.07%, Group A 44.07%, Group B 9.26%, Group AB 2.60%, and Rh(+) 83.70% and Rh(-)16.30%. According to our knowledge, there is no prior study on distribution of blood groups in the Eastern Black Sea region of Turkey. When compared to data throughout Turkey, it has been found out that the rate of blood group O is significantly higher, and the rates of blood groups B and AB are significantly lower. Conclusion: We believe that our results would contribute to database construction on distribution of blood groups

Analysis of ABO and Rh blood groups distribution in East Karadeniz region of Turkey

Objective: Accurate knowledge on the distribution ofblood groups in a region is useful for individuals in needand blood bank processes as well as such knowledgewould provide scientific contribution. In this study, our objectiveis to determine ABO and Rh blood groups distributionin the Rize province.Materials and methods: Retrospective analysis hasbeen conducted on the data of 38,329 individuals appliedto Blood Center of Rize Training and Research Hospitalfor blood group determination. The data collection periodcovers five years, between January 2005 and December2010.Results: Our findings indicated that the frequencies of theblood groups were as following: Group O 44.07%, GroupA 44.07%, Group B 9.26%, Group AB 2.60%, and Rh(+)83.70% and Rh(-)16.30%. According to our knowledge,there is no prior study on distribution of blood groups inthe Eastern Black Sea region of Turkey. When comparedto data throughout Turkey, it has been found out that therate of blood group O is significantly higher, and the ratesof blood groups B and AB are significantly lower.Conclusion: We believe that our results would contributeto database construction on distribution of blood groups.Key words: ABO Blood-Group System, Rize, Turke