Histopathological Evaluation of Behçet's Disease and Identification of New Skin Lesions

Behçet's disease (BD) is a multisystemic, relapsing inflammatory disorder with an obscure etiology and pathogenesis. Diagnosis depends on the clinician's ability to identify a group of nonspecific mucocutaneous lesions, which also manifest in a number of other diseases. In recent years, there has been an increase in the studies focusing on the histopathological aspects of Behçet's disease diagnostic mucocutaneous lesions. Their results emphasize the value of histopathology and direct immunofluorescence (DIF) in the differential diagnosis of Behçet's disease

Effect of the coronavirus disease-2019 pandemic on the follow-up and treatment of patients with rosacea

Background and Design: This study aimed to investigate the effects of the precautions and preventive measures implemented during the coronavirus disease-2019 (COVID-19) pandemic on the follow-up and treatment processes of patients with rosacea who applied to the Skin and Venereal Diseases outpatient clinic of a university hospital in Türkiye. Materials and Methods: Age, sex, number of hospital admissions, prescribed topical and systemic treatments, total amount of treatment on a box basis, follow-up interval in multiple applications, and number of applications to the Ophthalmology Department were recorded before and during the COVID-19 pandemic. Results: No difference was found in the age and sex distributions of patients with rosacea who applied to the Skin and Venereal Diseases outpatient clinic during the COVID-19 pandemic compared with that before the pandemic. However, the total number of patients decreased. Furthermore, the total number of drugs prescribed to patients and the number of systemic drugs increased proportionally during the COVID-19 pandemic. In addition, the ratio of patients who continued their follow-up and the use of systemic drugs among these patients increased. Conclusion: In this study, the number of admissions decreased and the rate of patients who needed systemic treatment increased. Rosacea and similar dermatoses that required long-term follow-up could be evaluated via teledermatology during periods when application to outpatient clinics for follow-up becomes difficult such as during pandemics and natural disasters

Micronutrient Deficiencies and Digital Computerized Phototrichogram Analysis in Telogen Effluvium: A Retrospective Correlation Study in a Tertiary Medical Center

Introduction:Telogen effluvium (TE) is a common form of non-scarring alopecia that may manifest as acute or chronic hair shedding. Several studies evaluated a possible relationship between various vitamin and mineral deficiencies and TE, but it is still a controversial topic. Objectives: This study aimed to investigate the status of vitamin and mineral deficiencies in patients diagnosed with TE and to evaluate their correlation with anagen hair ratios (AHR) calculated with an automated digital phototrichogram (ADCP). Methods:Electronic records of 973 TE patients were retrospectively analyzed. Demographic, clinical data, parameters such as ferritin, vitamin B12 (Vit-B12), vitamin D (Vit-D), folic acid, zinc and hemoglobin (HGB) serum levels were evaluated. Anagen to telogen hair ratios were also assessed in forty-two patients via ADCP. Results: The rates of anemia, low ferritin level, and Vit-B12, folate, Vit-D, and zinc deficiencies were 11.9% (N = 109), 44% (N = 332), 1.5% (N = 13), 2.5% (N = 14), 87% (N = 51), and 4.5% (N = 2), respectively. A positive correlation was found between HGB levels and AHR in female patients (Spearman rank, r = 0.417, P = 0.008). No statistically significant relationship was found between ferritin, Vit-B12, folate, zinc serum levels and AHR. The relationship between Vit-D and AHR could not be assessed due to the insufficient number of patients with Vit-D data. Conclusions:HGB value is the only marker that is positively correlated with the AHR of patients with TE. Ordering HGB can be used as an initial test for managing TE patients cost-effectively.

The effect of art activities of Adiyaman philharmonic orchestra on urban life

bu araştırmada, adıyaman'da kurulan ilk filarmoni orkestrası ile icra edilen sanat faaliyetlerinin kentin müzik kültürü ve şehir halkı üzerindeki etkileri araştırılmıştır. araştırma kapsamında, adıyaman’da konser etkinliklerine katılan belirli sayıda kişi ile sınırlı tutularak, adıyaman filarmoni orkestrası’nın (afo) konser ve etkinlik faaliyetlerinin genel olarak şehir halkı üzerindeki kültürel etkisi değerlendirilmeye çalışıldı. adıyaman’da konserlere katılan sınırlı sayıdaki ailelere ve öğrencilere 10 sorudan oluşan bir anket uygulanmış, elde edilen veriler çapraz sorgulama tekniği ile irdelenmiş ve cevaplar arasındaki ilişkilendirmeler yapılmıştır. bu çalışmanın sonucunda, orkestranın konser etkinlik faaliyetlerinin kent yaşamı içinde şehir için çok önemli bir yere sahip olduğu belirlenmiştir. anket çalışmasına katılanlara göre, çocuklar için yapılan sanat faaliyetlerinin olumlu olduğu tespit edilmiştir. katılımcılar, filarmoni orkestrası’nın kentte icra ettiği sanat faaliyetlerinin kültür ve sanat hayatının yanı sıra, adıyaman'da ekonomik anlamda da pozitif katkı ve etki sağladığı kanaatindedir. etkinlik kapsamında oluşturulan konser repertuarında türk ve yerel bestecilerin eserlerine daha fazla yer verilmesi yönündedir. ayrıca adıyaman'da ilk filarmoni orkestrası sanat faaliyetlerinin kent insanı üzerinde farklı alanlarda pozitif etki oluşturduğu ve konunun geliştirmesinde ve iyileştirilmesinde halkın daha fazla beklenti içinde olduğu tespit edilmiştir.In this study, the effects of the art activities of the first philharmonic orchestra in Adıyaman, which is one of the provinces of the Southeastern Anatolia Region of our country, were investigated. A limited number of surveys were conducted in Adıyaman with survey questions prepared to determine these effects. In this study, the obtained data were analyzed by cross-query technique and the correlations were obtained. As a result of this study, it was determined that the people living in the region cared about the concert activities of the orchestra. Participants of the survey found that children's art activities were positive. The participants thought that the art activities carried out by the Philharmonic orchestra in the city provided a positive contribution and influence in Adıyaman. In the concert repertoire created within the scope of the event, the works of Turkish and local composers were to be included. In addition, it was determined that the first philharmonic orchestra art activities in Adıyaman had a positive effect on the urban people in different areas and the expectations of the public in the development and improvement of this issue

Non-opioid Analgesics and the Endocannabinoid System

Non-steroidal anti-inflammatory drugs produce antinociceptive effects mainly through peripheral cyclooxygenase inhibition. In opposition to the classical non-steroidal anti-inflammatory drugs, paracetamol and dipyrone exert weak anti-inflammatory activity, their antinociceptive effects appearing to be mostly due to mechanisms other than peripheral cyclooxygenase inhibition. In this review, we classify classical non-steroidal anti-inflammatory drugs, paracetamol and dipyrone as “non-opioid analgesics” and discuss the mechanisms mediating participation of the endocannabinoid system in their antinociceptive effects. Non-opioid analgesics and their metabolites may activate cannabinoid receptors, as well as elevate endocannabinoid levels through different mechanisms: reduction of endocannabinoid degradation via fatty acid amide hydrolase and/or cyclooxygenase-2 inhibition, mobilization of arachidonic acid for the biosynthesis of endocannabinoids due to cyclooxygenase inhibition, inhibition of endocannabinoid cellular uptake directly or through the inhibition of nitric oxide synthase production, and induction of endocannabinoid release

Dynamic content updates in heterogeneous wireless networks

Content storage at the network edge is a promising solution to mitigate the excessive traffic load due to on-demand streaming applications as well as to reduce the streaming delay. To this end, cache-enabled cellular architectures can be utilized to increase the provided quality-of-service (QoS) and to reduce the network cost. However, there are certain issues to be considered in the design of the content storage strategy such that the contents should be refreshed in order to responds user`s expectations. Using a frequent cache refreshment strategy the ratio of satisfied users can be increased at an increasing network cost. In this paper, we introduce a cache refreshment strategy via leveraging learning techniques so that users' tolerance to the age of content is learned and the content is refreshed accordingly

Yttrium-90 radioembolization for the treatment of unresectable liver cancer: Results of a single center

Objective: To determine the effects of yttrium-90 (Y-90) resin microsphere radioembolization therapy on patients with unresectable liver cancer who do not benefit from chemotherapy. Methods: Fifty-five patients underwent radioembolization therapy included in the study whose had unresectable primary or metastatic liver cancer originating from the gastrointestinal tract. Three were excluded from the study after pre-evaluation angiography. Thirteen (23.6%) of the remaining 52 patients had hepatocellular carcinoma and 39 (76.4%) had metastatic liver cancer. Fifty-two patients underwent Y-90 radioembolization treatment. Each patient's response to the administered treatment was evaluated using the Response Evaluation Criteria in Solid Tumors (RECIST) and the overall probability of survival was displayed graphically by the Kaplan-Meier method. Results: After Y-90 therapy, 47 patients were follow-up. While 57% of the patients responded to treatment as clinical benefit, the disease progressed in 43%. The median hepatic progression-free survival time of the patients was 3.4 months (95% confidence interval (ci):1.4-5.3) and the overall survival time was 11.3 months (95%, CI:8.7-14.03). Conclusion: This study emphasizes that Y-90 resin microsphere radioembolization treatment is effective in patients with unresectable liver cancer

International competitiveness power and human development of countries

Human development should be the ultimate objective of human activity and its aim should be healthier, longer, and fuller lives. It is expected that if the competitiveness of a country is suitably managed, human welfare will be enhanced as a consequence. The research described here seeks to explore the relationship between the competitiveness of a country and its use for human development. For this purpose, 45 countries were evaluated using data envelopment analysis, where the global competitiveness indicators are taken as input variables and the human development index indicators as output variables. A detailed analysis is also conducted for the emerging economies

A study on technology management process: the parts and components suppliers in the Turkish automotive industry

This paper summarizes part of an empirical study on technology management process in the Turkish automotive parts and components industry. In this study, technology management practices in the Turkish automotive parts and components suppliers' sector are described and evaluated. Practices, techniques, and approaches are proposed to improve the level of technology management so as to turn technology into a competitive weapon. The investigation is organized within the framework of a process model for technology management that consists of technology identification, selection, acquisition, exploitation, protection, and abandonment. A comprehensive questionnaire addressing all phases of this process is developed and the results of 21 companies are presented