Acute cyanide poisoning caused by apricot kernel

[No Abstract Available

The Effect of Water Deficit on some Physiological Properties of Abelmoschus esculentus (L.) Moench cv. "Sultani"

This study was conducted to determine the some physiological changes after the artificial drought stress in okra (Abelmoschus esculentus (L.) Moench cv."Sultani") which is widely cultivated in Turkey and well adapted to Trakya region. After germination, the seedlings were grown under normal growing conditions in an unheated plastic greenhouse until they reached to 2-4 leaf. They were planted in the field with a distance of 50 cm between rows and 25 cm in rows. The plants normally irrigated until flowering time. After then, water constraint applied for drought stress. Control plants were irrigated to bring to field capacity, when they lost 50% of usable water capacity in root region. Other plots were irrigated to 0%, 25% and 50% of applied water in control parcel. Water restriction was done once a week and then measurements were made. During the experiment, leaf water potential (-MPa), leaf relative water content (%), membrane damage in leaf cells (%) and total chlorophyll (SPAD value) in leaves were determined. As results, it has been determined that as the amount of water restriction goes from control to 0%, the leaf water potential decreases and the plants grown at 0% water constraint show severe damage symptoms. It has also been found that the amount of leaf-relative water content and the total amount of chlorophyll are reduced in a manner contrary to the increase in drought stress. Contrary to other criteria, membrane damage and leaf temperatures increase in leaf cells due to the increase in the amount of water restriction

Non–Vitamin K Antagonist Oral Anticoagulants, Clinical Use, Real-World Data, and Reversal of Anticoagulant Effect

Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia in clinical practice and is associated with a higher risk of thromboembolic events. CHA2DS2VASc score enables identification of those patients with AF who will most benefit from anticoagulation therapy and low-risk patients with AF who do not need any antithrombotic therapy. Antithrombotic drugs especially oral anticoagulants (OACs) are the mainstay of therapy to prevent stroke in patients with AF. Although vitamin K antagonists (VKAs) were the only available drugs for decades, numerous non–vitamin K antagonist oral anticoagulants (NOACs) have been developed and marketed for stroke prevention in recent years. The risk of stroke was reported to decline up to 68 % with OAC therapy, associated with good anticoagulation control with VKAs, assessed by time in therapeutic range (TTR). In low TTR values, VKAs were found to be associated with severe complications, and a minimum TTR of 58 % should be achieved to expect a net benefit from being on OAC therapy. Narrow therapeutic index, drug-drug interactions, and the need for close monitoring are the main disadvantages of VKAs, and management of patients have dramatically improved after the introduction of NOACs. NOACs have a more predictable anticoagulant affect which allows a fixed-dose regimen. The efficacy and safety of NOACs have been shown not only in large randomized controlled clinical trials but also in observational studies. The main advantages of NOACS such as “fixed-dose regimen” and “no need for regular anticoagulant therapy monitoring” may also be the Achilles heel of the use of these agents. Fixed-dose regimen may not be appropriate for elderly, for patients with chronic kidney disease, and for patients using interacting drugs. Adherence to NOAC therapy is another concern as it may be as low as 50 % in the chronic use of cardiovascular drugs, especially if the drug has no apparent affect to the patient. Thus, appropriate use of OACs among non-valvular AF (NVAF) patients is essential for stroke prophylaxis. We intended to review the use of OAC therapy among (NVAF) patients

A greedy gradient-simulated annealing hyper-heuristic for a curriculum-based course timetabling problem

Copyright © 2012 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other users, including reprinting/ republishing this material for advertising or promotional purposes, creating new collective works for resale or redistribution to servers or lists, or reuse of any copyrighted components of this work in other works.12th UK Workshop on Computational Intelligence (UKCI), Edinburgh, Scotland, 5-7 September 2012The course timetabling problem is a well known constraint optimization problem which has been of interest to researchers as well as practitioners. Due to the NP-hard nature of the problem, the traditional exact approaches might fail to find a solution even for a given instance. Hyper-heuristics which search the space of heuristics for high quality solutions are alternative methods that have been increasingly used in solving such problems. In this study, a curriculum based course timetabling problem at Yeditepe University is described. An improvement oriented heuristic selection strategy combined with a simulated annealing move acceptance as a hyper-heuristic utilizing a set of low level constraint oriented neighbourhood heuristics is investigated for solving this problem. The proposed hyper-heuristic was initially developed to handle a variety of problems in a particular domain with different properties considering the nature of the low level heuristics. On the other hand, a goal of hyper-heuristic development is to build methods which are general. Hence, the proposed hyper-heuristic is applied to six other problem domains and its performance is compared to different state-of-the-art hyper-heuristics to test its level of generality. The empirical results show that the proposed method is sufficiently general and powerful

Choosing solitude in turmoil, herding in the decentralized finance (DeFi) token market: An international perspective

Financial markets have long been known to be prone to behavioral biases. One such behavioural bias that is consequential yet pervasive in financial markets is the herd effect. The objective of this study is to determine whether or not there exist herd behaviour in the new and bourgeoning Decentralized Finance (DeFi) Tokens market. This is accomplished by using daily returns of 22 DeFi tokens from January 29, 2017 to August 19, 2021, and the Cross-sectional Absolute Deviation (CSAD) of market returns to capture herd behavior. The results fail to provide any evidence of herding in the DeFi token market on bullish days, that is days for which the average market returns is positive. For bearish days however, that is days for which the market returns is negative, our empirical findings point to the presence of adverse herding in the DeFi token market. This phenomenon can be explained to some extent by the investor composition of the DeFi market. The DeFi token space is a growth market dominated by experts and/or enthusiasts who are insulated against the temptation and panic of negative market swings by the level of market and technical information they possess on the assets they invest

From idea to publication: Publication rates of theses in neurosurgery from Turkey

Objectives Thesis at the end of residency is considered as the complementary component of postgraduate training. In this respect, thesis helps the residents learn how to ask structured questions, set up the most appropriate study design, conduct the study, retrieve study results and write conclusions with clinical implications. To the best of our knowledge, the publication rates of theses in the field of neurosurgery have not been reported before. Our aim was to find out publication rates of theses in neurosurgery specialty, in this descriptive study. Methods The database of Higher Education Council of Turkey, which includes the theses of residents in only university hospitals, was screened between years 2004 and 2013. After retrieving the theses from the database; we used search engines to find out the theses published in any SCI/SCI-E-indexed journals. For this purpose, the title of the theses and the author names were used as keywords for searching. Data was presented in a descriptive form as absolute numbers and percentages. Results We retrieved 164 theses written by former residents in neurosurgery using the database. Among 164 theses, 18% (national journals: 9; international journals: 21) were published in SCI/SCI-E indexed journals. Conclusion Publication rates of theses in neurosurgery are low as they are in the other specialties of medicine. Our study is a descriptive research, to give an idea about publication rates of theses in neurosurgery. Further studies are required to understand the underlying factors, which are responsible for the limited success in publication of theses in neurosurgery

Investigation of impact of DC component on breakdown characteristics for different electric fields under composite AC & DC voltage

The valve side of the converter in the high-voltage direct current is subjected to mixed voltages such as composite AC & DC voltage. In this study, the effects of the homogeneity of electric field on breakdown voltage were investigated for different ±DC component amplitudes of the composite voltage. The field efficiency factor was calculated using mean and maximum field strengths for all of them. Variation of breakdown voltage of air was examined under the composite AC & DC voltage for different ratios ±DC. As one result of the study, the breakdown occurs at the positive half-wave of the AC voltage despite −DC voltage being applied due to positive corona discharge pulses. This breakdown point is named as the polarity change point. The breakdown voltage increases with the decrease of DC voltage component up to polarity change point in non-uniform electric field. In less uniform electric field, the AC breakdown voltage was measured slightly higher than the DC breakdown voltage. In less uniform electric field, as the ratio of the applied AC voltage to DC voltage increases, the breakdown voltage gradually approaches the AC breakdown voltage. This result is similar to the result obtained for the +DC component in non-uniform electric field experiments

The effect of DC voltage pre-stress on breakdown voltage of air under composite DC & LI voltage and test circuit: design and application

The use of HVDC systems is increasing in number due to technological innovations, increasing power capacity and increasing customer demand. The characteristics of insulation systems under composite DC and LI voltage must be examined and clarified. In this study, firstly, experimental circuits were designed to generate and measure composite DC and LI high voltage using a simulation program. The coupling elements used were chosen according to simulation results. Afterward, experimental circuits were established in the laboratory according to the simulation results of the designed experimental circuit. Then, breakdown voltages under composite DC and LI voltage for less uniform and non-uniform electric fields were measured with four different electrode systems for positive and negative DC voltage pre-stresses with different amplitudes. The 50% breakdown voltage was calculated using the least-squares method. Finally, 3D models were created for the electrode systems used in the experiments using the finite element method. The efficiency factors of electrode systems calculated with the FEM results were correlated with the experimental breakdown voltage results. Thus, the breakdown behavior of air under bipolar and unipolar composite voltages (CV) was investigated. In conclusion, the experimental results showed that very fast polarity change in bipolar CV causes higher electrical stress compared to unipolar CV

Hyperbilirubinemia due to minor blood group (anti-E) incompatibility in a newborn: A case report

In addition to Rh and ABO incompatibilities subgroup incompatibilities may rarely play a role among the causes of hemolytic anemia and indirect hyperbilirubinemia in newborns. The most common minor blood group antigens that cause blood incompatibility between the mother and baby are C, c, E, e, Kell, Duffy, Diego, Kidd and MNSs antigens. In this article, a newborn in whom hyperbilirubinemia due to anti-E minor blood group incompatibility developed and was treated with phototherapy succesfully is presented and minor blood group incompatibilities due to anti-E are reviewed

Servikal Ranula: Bir Olgu Sunumu

Plunging veya servikal ranula sublingual bezden kaynaklanan ve mylohyoid kası içinden uzanım gösteren nadir görülen bir mukus ekstravazasyon kistidir. Mukus doku planlarını ayırarak aşağı doğru iner ve sıklıkla submental veya submandibular alanda şişlik olarak kendini gösterir. Tedavide ile seçenek plunging ranulanın cerrahi eksizyonudur. Basit eksizyon, marsüpiyalizasyon ve intraoral veya servikal yaklaşımla ranula ve sublingual gland eksizyonu gibi çeşitli cerrahi varyasyonlar bulunmaktadır. Bu tedavi seçeneklerine rağmen hastaların bir kısmında rekürrens görülmekte ve daha büyük lezyonlar ortaya çıkabilmektedir. Skleroterapi cerrahi önerilmeden önce primer tedavide kullanılabilecek potansiyel küratif bir tedavi prosedürüdür. Tedavisinde servikal yaklaşım ile sublingual gland ve plunging ranulanın total eksizyonu uygulanan bir olgu sunuldu