48-72 Aylık çocuklar için Okul Öncesi İşitsel İşlemleme Testi (İŞTE)’nin geçerlik ve güvenirlik çalışması

Bu çalışma okul öncesi dönem çocukların işitsel işlemleme becerilerini değerlendirmek üzere geçerli ve güvenilir bir ölçme aracının geliştirilmesi amacıyla tasarlanmıştır. 48-72 aylık çocuklar için geliştirilen Okul Öncesi İşitsel İşlemleme Testi (İŞTE) listeleri, alan yazın taraması yapılarak hazırlanmıştır. Alan uzmanlarından alınan görüşler doğrultusunda test düzenlenmiş ve ardından Lawshe analizi uygulanarak yüzey ve kapsam geçerliliği sağlanmıştır (KGO=0.99, p<0.05). Test, araştırmacı tarafında 48-72 aylık 502 çocuğa uygulanmış, yapı geçerliliğinin sınanması için faktör analizi işlemleri öncesinde örneklem büyüklüğünün uygunluğunu belirleyebilmek amacıyla Kaiser-Meyer-Olkin Testi yapılmıştır (KMO=0.88; x2  (231) =6905.36; p<0.01). Açımlayıcı faktör analizi sonucunda İŞTE’nin öz değeri 1 ve 1 den fazla olan 4 faktörlü bir yapıdan oluştuğu görülmüştür. Alt testler iç tutarlılık katsayıları  Ses Bilgisel Farkındalık: Aynı Sesle Başlayanlar (α=0.84), Ses Bilgisel Farkındalık: Aynı Sesle Bitenler(α=0.86), Kısa Süreli İşitsel bellek(α=0.94), İşitsel Ayırt Etme (α=0.78) ve İŞTE toplamı (α=0.88) olarak hesaplanmıştır

A rare complication of recurrent cerebrovascular infarct: Bilateral vocal cord paralysis

Bilateral vocal cord paralysis (BVCP) is usually the result of an iatrogenic injury especially secondary to thyroid and parathyroid surgery. However, BVCP that cause airway obstruction due to serebral cortical stroke very rarely has been reported. We, herein report a case of BVCP that resulted in respiratory arrest as a late and life threatening complication of recurrent cerebral infract. A 67 years old male patient admitted the emergency room with complaint of respiratory insufficiency. His complaint was progressed during last 3-4 months. He had two cerebral infractions attacks in a month approximately one year ago. On admission, physical examination revealed that, he had bilateral wheezing and stridor. He had right sided hemiplegia and had no history of heart failure or chronic obstructive lung disease. Endoscopic laryngoscopy was performed to evaluate upper airway obstruction. Laryngoscopy revealed that bilateral vocal cords were fixed and immobile at midline. Due to recurrent respiratory arrest, insufficient and fixed BVCP, open tracheostomy was perormed. After operation, he had no respiratory insufficiency or any complications. So he discharged from hospital with normal respiratory function

Makine öğrenimi yoluyla bölgesel arı sütü farklarının arkasındaki kimyasal faktörleri keşfetmek

This study aims to discover the characteristic chemical factors for determining the region of royal jelly using machine learning. 84 samples from 13 different regions of Turkey were used for the study, and the chemical parameters of moisture, pH, acidity, and 10-hydroxy-2-decanoic acid (10-HDA) were investigated. ANOVA test was conducted to determine whether there are differences between royal jelly from 13 locations concerning the four chemical values. In addition to the statistical tests, a machine learning model was used to find out what makes royal jelly different from each other. The descriptive statistics of the chemical analysis results of royal jelly showed the following values: moisture 63.05%±2.99, pH 3.67±0.08, acidity 45.32±3.55, and 10-HDA 2.40±0.24. Surprisingly, the machine learning model suggests that 10-HDA may be the most prominent parameter for determining the region of royal jelly. This information will help us identify royal jelly’s authenticity more easily.Bu çalışmanın amacı, makine öğrenmesi yoluyla arı sütünün bölgesini belirlemek için ayırt edici kimyasal faktörleri keşfetmektir. Çalışmada, Türkiye'nin 13 farklı bölgesinden 84 numune kullanılmış ve nem, pH, asitlik ve 10-hidroksi-2-dekanoik asit (10-HDA) kimyasal parametreleri incelenmiştir. 13 yerden toplanan arı sütleri arasında dört kimyasal değer açısından farklılık olup olmadığı ANOVA testi ile incelenmiştir. İstatistiksel testlere ek olarak, arı sütlerini birbirinden neyin ayırdığını keşfetmek için bir makine öğrenimi modeli kullanılmıştır. Arı sütü, kimyasal analiz sonuçlarının tanımlayıcı istatistikleri sırasıyla, nem %63,05±2,99, pH 3,67±0,08, asitlik 45,32±3,55 ve 10-HDA 2,40±0,24 olarak bulunmuştur. Şaşırtıcı bir şekilde, makine öğrenimi modeli, 10-HDA'nın arı sütünün bölgesini belirlemek için en belirgin parametre olabileceğini öne sürmektedir. Bu bilgi, arı sütünün doğruluğunun tespitini daha kolay öğrenmemize yardımcı olacaktır

The effect of breast-feeding duration on bone mineral density in postmenopausal Turkish women: a population-based study

Alcelik, Aytekin/0000-0002-3156-1076WOS: 000292798400018PubMed: 22295033Introduction: In the present study, we investigated the effects of breast-feeding time on bone mineral density (BMD) later in life. Material and methods: The current study was based on a retrospective analysis of 586 postmenopausal women with a mean age of 60.8 years, who were screened for osteoporosis by dual energy X-ray absorptiometry (DXA). They were classified into 4 groups with respect to the duration of their breast-feeding as never (group 1), 1-24 months (group 2), 25-60 months (group 3), or > 60 months (group 4). Bone mineral density results for the femur neck and lumbar spine were classified into 3 groups according to WHO criteria as normal (T score > -1.0 SD), osteopenia (T score -1.0 to -2.5 SD), and osteoporosis (T score < -2.5 SD). Patients with osteopenia or osteoporosis (T score < -1.0 SD) were considered as having low bone mass (LBM). Results: We found a correlation between duration of lactation and femur BMD or spine BMD in the study population (r = 0.116, p < 0.005; r = -0.151, p = 0.001, respectively). Significant differences were found between femur BMD and spine BMD of groups in one-way ANOVA analysis (p = 0.025, p = 0.005, respectively). Additionally, when compared with the other three groups, group 4 was older and had longer duration of menopause (p < 0.01). In logistic regression analysis, age and body mass index were found as independent risk factors of LBM [odds ratio: 1.084 (95% CI 1.031-1.141); odds ratio: 0.896 (95% CI 0.859-0.935)], while duration of lactation was not found as an independent predictor of LBM. Conclusions: In this study, we have found that changes of bone metabolism during lactation had no effect on postmenopausal BMD measured by DXA. Consequently, it can be suggested that long breast-feeding duration is not a risk factor for low bone mass later in life

Recurrent and Massive Life Threatening Epistaxis due to Nasal Heroin Usage

Epistaxis, active bleeding from the nose, is a common ear nose and throat emergency, and can be severe or even fatal. We report a severe life threatening recurrent massive nasal bleeding caused by intranasal heroin use that has not hitherto been reported in the English literature. A 24-year-old male who took heroin several times nasally presented with massive nasal bleeding. A blood transfusion and an operation to halt nasal bleeding were required. The patient did not experience a bleeding attack 2 months following cessation of nasal heroin use

A comparison of the 2 thermal ablation procedures for the management of benign thyroid nodules

Introduction: In recent years, ultrasound (US)-guided thermal ablation techniques have come to the fore as minimally invasive alternatives to surgery. The purpose of this study was to assess the effectiveness and safety of radiofrequency ablation or microwave ablation procedures in patients with benign thyroid nodules. Material and methods: This retrospective and single-centre study consisted of 55 patients and 62 benign thyroid nodules that were treated either with radiofrequency ablation (RFA) or microwave ablation (MWA) in our hospital between January 2020 and March 2022. All the patients were at high risk for surgery or with symptomatic TNs and who refused surgery. The TNs diagnosed as benign from the fine-needle aspiration biopsy were evaluated in terms of volume reduction, symptom, and cosmetic scores. In addition, these 2 treatment modalities were compared to each other. Results: Out of 55 patients, 44 (80%) were female and were aged between 24 and 97 years with a median age of 50 years. RFA was applied to 54.5% (n = 30) of the participants, and MWA was applied to 46.5% (n = 25). The volume reduction rate (VRR) after RFA and MWA at the first month was 63.4 ± 14.2 and 65.7 ± 13, respectively. No significant difference was detected between the 2 groups in terms of VRR (p = 0.51). In addition, the mean symptom and cosmetic scores decreased significantly in both procedures, and there was a significant difference due to the symptom score change in the RFA group compared to the MWA group. Of all the patients, one patient experienced haematoma in the RFA, and one patient had transient voice change in the MWA group. No life-threatening complications were noted. Conclusion: In the treatment of benign symptomatic thyroid nodules, both RFA and MWA are options worthy of consideration in terms of efficacy and safety

Explant Culture of Ovarian Tissue

INTRODUCTION: In this study, it was aimed to isolate, reproduce and characterize stromal cells migrating from tissues by creating ovarian tissue explant culture. It is also aimed to create a mixed cell culture (ovarian stromal stem cells and ovarian surface epithelium) with the tissues obtained from different parts of the ovary and to examine the interactions of the cells with each other. METHODS: Explant cultures were formed from ovarian tissues of 4 week old (prepubertal) two female Wistar Albino type rats. Then, the expression of CD29, CD54, CD90 (mesenchymal stem cell surface antigen) and CD45 (hematopoietic stem cell surface antigen) was investigated by performing flow cytometry analysis on proliferating ovarian stromal cells in the 2nd passage (P2). RESULTS: The proliferation abilities and morphological characteristics of the cells in the culture medium were examined by serial passaging. In flow cytometry analysis of isolated ovarian stromal cells, it was determined that they expressed CD54, CD90 and CD45 surface antigens, but did not express CD29 surface antigens. DISCUSSION AND CONCLUSION: In the analysis, we determined that the ovarian stromal cells we isolated and produced in the culture medium expressed hematopoietic and some mesenchymal stem cell markers

Comprehensive dissection of prevalence rates, sex differences, and blood level-dependencies of clozapine-associated adverse drug reactions

Clozapine is often underused due to concerns about adverse drug reactions (ADRs) but studies into their prevalences are inconclusive. We therefore comprehensively examined prevalences of clozapineassociated ADRs in individuals with schizophrenia and demographic and clinical factors associated with their occurrence. Data from a multi-center study (n=698 participants) were collected. The mean number of ADRs during clozapine treatment was 4.8, with 2.4% of participants reporting no ADRs. The most common ADRs were hypersalivation (74.6%), weight gain (69.3%), and increased sleep necessity (65.9%), all of which were more common in younger participants. Participants with lower BMI prior to treatment were more likely to experience significant weight gain (>10%). Constipation occurred more frequently with higher clozapine blood levels and doses. There were no differences in ADR prevalence rates between participants receiving clozapine monotherapy and polytherapy. These findings emphasize the high prevalence of clozapine-associated ADRs and highlight several demographic and clinical factors contributing to their occurrence. By understanding these factors, clinicians can better anticipate and manage clozapine-associated ADRs, leading to improved treatment outcomes and patient well-being