The influence of plasma 25-(OH) vitamin D levels in acute ST elevation myocardial infarction

Background: The preventive role of acute occurring of collateral circulation (AOCC) to infarct related artery (IRA) in patients presenting with acute ST-segment elevation myocardial infarction (STEMI) is well known. Therefore, we aimed to investigate whether there is an association between admission plasma 25-hydroxyvitamin D (25(OH)D3) levels and grade of collateralization in patients with STEMI. Methods: We prospectively included 369 STEMI patients within the first 12 h of symptoms onset. Patients were divided into two groups according to their Rentrop collateralization grade to IRA: poorly developed collateral (PDC) group (Rentrop grade ≤ 1, 272 patients) and well developed collateral (WDC) group (Rentrop grade ≥ 2, 97 patients). Results: We observed that AOCC grade to IRA was negatively correlated with high sensitive C-reactive protein (hs-CRP), N terminal pro-B-type natriuretic peptide (NT-proBNP), as well as peak troponin T levels, yet positively correlated with admission plasma 25(OH)D3 level (p < 0.05, for all). In multi¬variate analysis, 25(OH)D3 levels (OR 1.246, 95% CI 1.185–1.310, p < 0.001), together with hs-CRP, NT-proBNP, and peak troponin T levels were found independent predictors of AOCC to IRA in patients with acute STEMI. Conclusions: Admission level of plasma 25(OH)D3 levels together with cardiac risk biomarkers (troponin T, NT-proBNP, hs-CRP) are associated with collateralization grade to IRA in acute STEMI patients. In addition, 25(OH)D3 may be a promoter of AOCC in patients with acute STEMI

Sinotomy technique versus surgical excision with primary closure technique in pilonidal sinus disease

Pilonidal disease is a common chronic disorder mainly seen in the sacrococcygeal region, especially in young males. Many surgical treatment modalities have been suggested, but an ideal and widely accepted treatment has yet to be established. The aim of this study was to compare quality of life of patients treated with the sinotomy technique with quality of life of patients treated with surgical excision plus primary closure technique by means of quality of life questionnaire. The data of patients who had been treated for pilonidal sinus in our clinic from September 2010 to June 2012 were analyzed retrospectively. Forty patients were treated with sinotomy technique and 40 patients were treated with surgical excision plus primary closure technique. Time to return to work and to time to complete wound healing were evaluated. All patients were asked to fill the questionnaire after complete healing occurred. Postoperative complications were bleeding in 2.5%, infection in 3.75% and fever in 2.5% patients. There were no significant differences between the two groups in terms of complete healing (p=0.1) and sport times (p=0.1). There were significant differences between the groups in terms of length of hospital stay (p≤0.001), time off work (p≤0.001),times to sitting on toilet and walking without pain (p=0.002 and p≤0.001,respectively). The mean postoperative VAS scores were 5.2±3.2 and 2.8±2.2, respectively (p=0.02). The technique of sinotomy with good wound and surrounding skin care seems to be an ideal approach with high chance of cure. The patients returned to their routine in a short period of time

Ömer Fevzi Atabek & eğitim yaşantısı

Ankara : İhsan Doğramacı Bilkent Üniversitesi İktisadi, İdari ve Sosyal Bilimler Fakültesi, Tarih Bölümü, 2014.This work is a student project of the The Department of History, Faculty of Economics, Administrative and Social Sciences, İhsan Doğramacı Bilkent University.by Ünsal, Mehmet Süha

Blueschist facies overprint of late Triassic Tethyan oceanic crust in a subduction–accretion complex in north-central Anatolia, Turkey

The late Cretaceous accretionary complex along the İzmir–Ankara–Erzincan suture zone, northern Turkey, includes various types of metamorphic rock together with radiolarite, sandstone, mudstone, serpentinite, basalt and limestone. Meta-plagiogranite blocks (up to 5 m in diameter) and a meta-gabbro slice (800 × 500 m) cross-cut by meta-plagiogranite are observed in a matrix of serpentinite, mudstone and radiolarian chert. These meta-gabbros and meta-plagiogranites show subduction-related geochemical characteristics. Laser ablation inductively coupled plasma mass spectrometry U–Pb dating of zircons from two meta-plagiogranites yielded 222.3 ± 1.5 and 227.2 ± 1.6 Ma crystallization ages. This study shows that the meta-gabbro and meta-plagiogranite from the accretionary complex are remnants of the metamorphosed equivalents of the late Triassic lower crustal rocks of the subducted Tethyan oceanic crust. They are the oldest lower crustal rocks observed in the İzmir–Ankara–Erzincan suture zone. Both the meta-gabbros and meta-plagiogranites have Na–Ca amphiboles, indicating blueschist facies metamorphism. However, phengites from a blueschist facies rock yielded an 40Ar/39Ar age of 104.3 ± 0.7 Ma, indicating that blueschist metamorphism occurred during the Albian. All these data suggest that the oceanic crust formed during the Norian, metamorphosed during the Jurassic to early Cretaceous and then dismembered during accretionary complex formation in the late Cretaceous