Accommodation Palsy in Multiple Sclerosis

In patients with multiple sclerosis and disturbed near vision, accommodation palsy can be observed as a relatively rare ocular complication. After ruling out other causes that may cause accommodation palsy, these patients may benefit from near glasses and the palsy may be self-limited with complete recovery over tim

Accommodation Palsy in Multiple Sclerosis

In patients with multiple sclerosis and disturbed near vision, accommodation palsy can be observed as a relatively rare ocular complication. After ruling out other causes that may cause accommodation palsy, these patients may benefit from near glasses and the palsy may be self-limited with complete recovery over time

Cerebral hemiatrophy associated with hematological and developmental disorders

The etiology of cerebral hemiatrophy may be congenital or acquired. Trauma, infection, vascular abnormality, ischemic and hemorrhagic conditions may be the etiologic factors in acquired type. There is limited information about its association with other disorders in the literature. We presented three new cases of cerebral hemiatrophy associated with some hematological and developmental disorders. Cerebral hemiatrophy was associated with thalassemia major in a 10-year-old girl, acute myeloblastic leukemia and Marfan syndrome in a 23-year-old man, and craniosynostosis in a 1-year-old boy. To the best of our knowledge, thalassemia major, myeloblastic leukemia, Marfan syndrome and craniosynostosis have not been reported in cerebral hemiatrophy in the literature. (J Pediatr Neurol 2004; 2(3): 171-174)

Investigation of the relationship between vitamin D and bone mineral density in newly diagnosed multiple sclerosis

Cure, Medine Cumhur/0000-0001-9253-6459WOS: 000316226800009PubMed: 22895896The aim of this study was to investigate the relationship between vitamin D and bone mineral density in newly diagnosed multiple sclerosis (MS) and to compare results with data from healthy controls. A total of 60 subjects, including 30 patients with MS, newly diagnosed and untreated (18 females, 12 males, at 18-40 years of age) and 30 healthy controls (20 female, 10 male) were enrolled in this study. Bone mineral density (BMD) of the lumbar spine and left femoral neck region were measured by dual-energy X-ray absorptiometry (DEXA). Serum levels of 25-hydroxyvitamin D (25OHD) were measured by chemiluminescence microparticle immunoassay (CMIA) on the Architect-i2000(A (R)) (Abbott) system. 25OHD levels of MS patients were significantly lower than in controls. 25OHD levels were 27.2 +/- A 14.1 ng/ml in MS patients and 42.6 +/- A 8.8 ng/ml in controls (p = 0.001). Twenty-six (86.6 %) of our patients had a reduced BMD in lumbar spine or femoral neck region; of these 24 patients (80 %) had osteopenia and 2 patients (6.6 %) had osteoporosis. Interestingly, there was no significant correlation between 25OHD and BMD in lumbar spine and femoral neck region (r = 0.454, p = 0,074; r = 0.636, p = 0.082). Interestingly, a significant reduction of bone density in female MS patients was observed. in our study, 25OHD deficiency and lower BMD appeared in newly diagnosed multiple sclerosis. This is compatible with shared etiologic or pathogenic factors in MS and osteopenia/osteoporosis, and calls for an active approach to optimize bone health in early stages of MS