Zygomatic abscess with temporomandibular joint effusion complicating acute otitis media

WOS: 000386676300007The incidences of extracranial and intracranial complications of acute otitis media (AOM) in children have markedly decreased in the postantibiotic era. Zygomatic abscesses are the rarest type of abscesses originating from mastoiditis. This paper presents a case with a zygomatic abscess as a complication of acute coalescent mastoiditis in a 7-year-old girl who underwent cortical mastoidectomy and myringotomy-ventilation tube insertion

Kıl keçilerinin döl ve süt verimi özellikleri üzerine genetik olmayan faktörlerin etkisi

The aim of this study was to determine the potential effect of non-genetic factors on certain production characteristics of Hair goats raised under semi-intensive management and dry- sub humid conditions, and to investigate phenotypic correlations between these traits. A generalized linear model was used to investigate the effect of non-genetic factors on gestation length (GL), number of services per conception (NSPC), lactation length (LL), lactation milk yield (LMY) and daily milk yield (DMY), while the Chi-square method was used to evaluate other fertility parameters. The pregnancy rate, birth rate and single-birth rate in the Traditional Group were higher, while the infertility rate and NSPC were lower, than those in the Artificial Group (P<0.001). Furthermore, it was determined that LL, LMY and DMY increased (P<0.001), the NSPC decreased (P<0.001), and birth and twinning rates fluctuated (P<0.01) as age increased. The best fertility and milk yield characteristics were in the ≥5 year-old-goats and live weights of 45.0-49.9 kg. In addition, it was determined that kid yield was increased in the goats synchronized with intravaginal sponges impregnated with fluorogestone acetate and in those bred via the traditional method.Bu çalışmanın amacı, yarı entansif ve kurak az nemli iklim koşullarında yetiştirilen Kıl keçilerinin döl verimi ve süt verimi üzerine genetik olmayan faktörlerin etkisini belirlemek ve bu faktörler arasındaki fenotipik korelasyonu araştırmaktır. Gebelik süresi (GL), gebelik başına düşen tohumlama sayısı (NSPC), laktasyon uzunluğu (LL), laskyason süt verimi (LMY) ve günlük süt verimi (DMY) üzerine genetik olmayan faktörlerin değerlendirilmesinde Genear linear model, diğer döl verim parametrelerinin değerlendirilmesinde ise Chi-square metodu kullanılmıştır. Tabii tohumlama yapılan gruptaki keçilerin gebelik oranı, doğu m oranı ve tek doğum oranı suni tohumlama uygulananlardan daha yüksek iken, NSPC sayısı daha düşüktür. Yaş arttıkça LL, LMY ve DMY artmış (P<0.001), NSPC azalmış (P<0.001), tek ve ikiz doğum oranları ise dalgalanma göstermiştir (P<0.01). En iyi döl verimi ve süt verimi nin 5 ve daha yukarı yaşlı ve 45.0-49.9 kg canlı ağırlığındaki keçilerde olduğu belirlenmiştir. Fluorogestone acetate içeren intravajinal sünger ile senkronizasyon ile tabii tohumlama uygulaması nın keçilerde oğlak verimini arttırdığı sonucuna varılmıştır

Türkiye’de inme hastalarında atrial fibrilasyonun yönetimi: NöroTek çalışması gerçek hayat verileri

Objective: Atrial fibrillation (AF) is the most common directly preventable cause of ischemic stroke. There is no dependable neurology-based data on the spectrum of stroke caused by AF in Turkiye. Within the scope of NoroTek-Turkiye (TR), hospital-based data on acute stroke patients with AF were collected to contribute to the creation of acute-stroke algorithms.Materials and Methods: On May 10, 2018 (World Stroke Awareness Day), 1,790 patients hospitalized at 87 neurology units in 30 health regions were prospectively evaluated. A total of 929 patients [859 acute ischemic stroke, 70 transient ischemic attack (TIA)] from this study were included in this analysis.Results: The rate of AF in patients hospitalized for ischemic stroke/TIA was 29.8%, of which 65% were known before stroke, 5% were paroxysmal, and 30% were diagnosed after hospital admission. The proportion of patients with AF who received "effective" treatment [international normalization ratio >= 2.0 warfarin or non-vitamin K antagonist oral anticoagulants (NOACs) at a guideline dose] was 25.3%, and, either no medication or only antiplatelet was used in 42.5% of the cases. The low dose rate was 50% in 42 patients who had a stroke while taking NOACs. Anticoagulant was prescribed to the patient at discharge at a rate of 94.6%; low molecular weight or unfractionated heparin was prescribed in 28.1%, warfarin in 32.5%, and NOACs in 31%. The dose was in the low category in 22% of the cases discharged with NOACs, and half of the cases, who received NOACs at admission, were discharged with the same drug.Conclusion: NoroTekTR revealed the high but expected frequency of AF in acute stroke in Turkiye, as well as the aspects that could be improved in the management of secondary prophylaxis. AF is found in approximately one-third of hospitalized acute stroke cases in Turkiye. Effective anticoagulant therapy was not used in three-quarters of acute stroke cases with known AF. In AF, heparin, warfarin, and NOACs are planned at a similar frequency (one-third) within the scope of stroke secondary prophylaxis, and the prescribed NOAC dose is subtherapeutic in a quarter of the cases. Non-medical and medical education appears necessary to prevent stroke caused by AF.Amaç: Atrial fibrilasyon (AF) iskemik inmenin doğrudan önlenebilir en sık nedendir. Ülkemizde AF nedenli inme spektrumuna dair nöroloji kaynaklı geniş ölçekte bir veri bulunmamaktadır. NöroTek-Türkiye (TR) kapsamında akut inme algoritmalarının oluşturulmasına katkı yapması beklenen AF tespit edilen akut inme hastalarına dair hastane verisi toplanmıştır. Gereç ve Yöntem: 10 Mayıs 2018 Dünya İnme Farkındalık Günü’nde 30 sağlık bölgesine yer alan 87 nöroloji biriminde yatmakta olan 1.790 hasta prospektif olarak değerlendirilmiştir. Çalışmada yer alan toplam 929 hasta [859 akut iskemik inme, 70 geçici iskemik atak (GİA)] bu analize dahil edilmiştir. Bulgular: İskemik inme/GİA sebebiyle ile interne edilmiş hastalarda AF oranı %29,8 olup bunların %65’i bilinmekte olan, %5’i paroksismal ve %30’u yeni tanıdır. AF tanısı ile gelen hastalarda “etkin” tedavi [internasyonel normalizasyon oranı ≥2,0 varfarin veya rehber dozunda non-vitamin K antagonist oral antikoagülan (NOAK)] alanların oranı %25,3 olup, %42,5 olguda ya hiç ilaç kullanılmamakta ya da sadece antiplatelet kullanılmaktaydı. Düşük doz kullanım oranı 42 NOAK alırken inme geçirmiş olguda %50 idi. Taburcu edilirken antikoagülan %94,6 (düşük molekül ağırlıklı veya non-fraksiyone heparin %28,1; varfarin %32,5 ve NOAK %31) hastaya reçete edilmişti. NOAK ile taburcu edilen olguların %22’sinde doz düşük kategoride olup gelişte NOAK almakta olan olguların yarısı aynı ilaçla taburcu edilmiştir. Sonuç: NöroTekTR ülkemizde AF’nin akut inmedeki sıklığı yanı sıra sekonder proflaksi perspektifinde yönetiminin geliştirilebilecek yönlerini ortaya koydu. Türkiye’de hastanede yatan akut inme olgularının yaklaşık üçte birinde AF saptanmıştır. AF’si bilinen akut inme olgularının dörtte üçünde etkin antikoagülan tedavi kullanılmamaktaydı. AF’de inme sekonder proflaksisi kapsamında heparin, varfarin ve NOAK planlaması benzer sıklıkta (üçte bir) olup reçete edilen NOAK dozu dörtte bir olguda subterapötiktir. AF’ye bağlı inmenin önlenebilmesi non-medikal ve medikal eğitim gerekli görünmektedir

Spatial Distribution and Encounter Rates of Delphinids and Deep Diving Cetaceans in the Eastern Mediterranean Sea of Turkey and the Extent of Overlap With Areas of Dense Marine Traffic

Marine traffic has been identified as a serious threat to Mediterranean cetaceans with few mitigation strategies in place. With only limited research effort within the Eastern Basin, neither baseline species knowledge nor the magnitude of threats have been comprehensively assessed. Delineating the extent of overlap between marine traffic and cetaceans provides decision makers with important information to facilitate management. The current study employed the first seasonal boat surveys within the Eastern Mediterranean Sea of Turkey, incorporating visual and acoustic survey techniques between 2018 and 2020 to understand the spatial distribution of cetacean species. Additionally, marine traffic density data were retrieved to assess the overlap with marine traffic. Encounter rates of cetaceans and marine traffic density were recorded for each 100 km2 cell within a grid. Subsequently, encounter and marine traffic density data were used to create a potential risk index to establish where the potential for marine traffic and cetacean overlap was high. Overall, eight surveys were undertaken with a survey coverage of 21,899 km2 between the Rhodes and Antalya Basins. Deep diving cetaceans (sperm and beaked whales) were detected on 28 occasions, with 166 encounters of delphinids of which bottlenose, striped and common dolphins were visually confirmed. Spatially, delphinids were distributed throughout the survey area but encounter rates for both deep diving cetaceans and delphinids were highest between the Rhodes and Finike Basins. While sperm whales were generally detected around the 1000m contour, delphinids were encountered at varying depths. Overall, two years of monthly marine traffic density were retrieved with an average density of 0.37 hours of monthly vessel activity per square kilometer during the study period. The mean density of vessels was 0.32 and 1.03 hours of monthly vessel activity per square kilometer in non-coastal and coastal waters respectively. The Eastern Mediterranean Sea has several important shipping lanes within the study area. Two priority areas for deep diving cetacean and a large priority area for cetaceans were identified in the waters between Marmaris and Finike where high cetacean encounters and dense marine traffic overlapped. The current study revealed important habitats for cetaceans within the data deficient Eastern Mediterranean Sea and delineated potential risk area where marine traffic should be limited

The impact of hybrid capture-based comprehensive genomic profiling on treatment strategies in patients with solid tumors

Objective: The development of bioinformatics and comprehensive genomic profiling (CGP) has provided insights into the ap-plicability and functionality of the genomic alterations (GA). In this study, we evaluated the impact of CGP on the treatment plan and outcomes in a significant number of patients. Material and Methods: We carried out a retrospective case-control study on 164 adult patients with advanced solid tumors from 15 oncology centers in Türkiye. Results: In all cases, CGP was performed within 23.8 [standard deviation (SD)±32.1] months of initial diagnosis. Non-small cell lung carcinoma, breast cancer, unknown primary carcinoma, colorectal carcinoma, and sarcoma were among the most common tumor types, accounting for 61.5% of all cases. CGP was performed immediately after the diagnosis of advanced cancer in 13 patients (7.9%). In 158 patients (96.4%), at least one GA was found as per the CGP report. Also, in the reports, the average tumor mutational burden (TMB) and GAs were 7.3 (SD±8.7) mut/Mb and 3.5 (SD±2.0), respectively. According to CGP reports, 58 patients had 79 evidence-based drug suggestions for their particular tumor type, whereas 97 patients had 153 evidence-based drug suggestions for another tumor type. After the primary oncologist interpreted the CGP reports, significant changes were made to the treatment of 35 (21.3%) patients. Conclusion: We strongly believe that in the future, high-TMB or other tumor-agnostic biomarkers will become much more afford-able, and CGP will serve as one of the major decision-making tools for the treatment of patients along with pathological, radiological or lab-oratory tests

Prognostic Factors in Operated Early Stage Lung Cancer Patients- Retrospective Single Center Data

Aim: Non-small cell lung cancer (NSCLC) accounts for 85% of all lung cancers. Although curative treatment is surgery in the early stages, disease relapse is common. In this study, we retrospectively evaluated the prognostic factors and outcomes of operated NSCLC cases.Materials and Methods: Retrospective analysis of data from 166 patients with early stage NSCLC who presented after surgery and treated and followed in our clinic between 2006-2018 was performed. Histopathologic features and clinical findings were investigated as prognostic factors.The findings were analyzed using SPSS.Results: At the time of diagnosis, median age was 61 (39-82) and 84% of the patients were male. Most common pathologic subtype was adenocarcinoma. Median disease free survival (DFS) and overall survival (OS) were 76 months (%95CI:32.1-110.0) and 87 months (95%CI:59.8-114.1). ). In multivariate analysis, presence of vascular invasion was found to be independent prognostic factors for both DFS and OS (HR:2.5 and 2.3, respectively). Adenocarcinoma solid pattern was only associated with worse disease-free survival (HR: 1.7).Conclusion: In our study, we showed that the presence of vascular invasion and solid-type adenocarcinoma is associated with poor survival

An overview of the latest ASCO recommendations about antiemetic prophylaxis for treatment-related nausea and vomiting

Nausea and vomiting (N&V) are among the most feared symptoms of cancer treatment. Since treatment-related N&V is predictable up to some extent, a systematic approach is recommended for prevention. Recently, ASCO has updated and released its' guideline for the prevention of treatment-related N&V. This paper is aimed to summarise the key changes and recommendations of ASCO for practicing medical or radiation oncologists treating adult cancer patients

Test technical / applications of standard in furniture industry: The case of Artvin

YÖK Tez No: 444804Türkiye'de işletmelerin çoğunda kalite kontrol rastgele yapılmakta ya da hiç yapılmamaktadır. Kontrol ve test aşamaları genellikle basit düzeyde kalmakta ve ayrıntıya dikkat edilmeden gerçekleştirilmektedir. Kalite kontrol ile ilgili kanunlarla belirlenmiş birçok standartlar mevcuttur. Fakat işletmelerin coğrafi yapı sisteminde dağınık olması, farklı ölçeklerdeki işletmelerin uygulamaları gereken mevzuatı bilinçli olarak uygulamalarına engel olmaktadır. Ayrıca yürürlüğe konulan yasaların sahada denetimlerin istenen düzeyde olmaması kaliteyi olumsuz etkilemektedir. Bu durumlar önemli ölçüde ekonomik kayıplara sebep olmakta ve üretilen ürünlerin, ulusal pazardan ziyade uluslararası pazarda yeterli paya ulaşamamaktadır. Mobilya üretiminde yapılan yanlışların önlenmesi yerine, hatayı ayıklama yöntemleri yaygın olarak kullanılmaktadır. Bu çalışmada, günümüz mobilya endüstrisi kalite kontrolünde kullanılan test/standart teknikleri araştırılmıştır. Çalışma Artvin ilindeki mobilya işletmelerini kapsamaktadır. Veriler yüz-yüze anket yöntemi yardımıyla elde edilmiş olup, 165 işletme çalışanına anket uygulanmıştır. Böylelikle tüm ülke bazında da işletme ve çalışanlar için neyin ne kadar önem taşıdığı, nasıl olması gerektiği gibi görüşler alınmıştır. Sonuç olarak, mobilya sektöründe faaliyet gösteren işletme çalışanlarının yaş, eğitim düzeyi, işletmedeki pozisyonu ve görev süreleri itibariyle mobilya test standartlarına ilişkin bazı cevaplar arasında anlamlı bir ilişkinin olduğu bulunmuştur.In Turkey in the most of the companies, quality control is made randomly or never made. Control and test phases are generally simply and they are carried out without considering the details. About quality control there are a lot of standards which were laid down by the laws. But companies are spread over different geographical areas and this hinders enterprises in various scales to apply consciously the legislation, which they have to apply. Also field supervision of the laws which were put into effect are unsatisfactory and that affects the quality negatively. These situations cause economic losses at considerable extent and manufactured products cannot gain a satisfactory place in the international market rather than national market. Instead of hindering the defects in furniture manufacture, debugging methods are commonly used. In this study, today's testing/standard techniques used for quality control in furniture industry are researched. The study contains the furniture companies in Artvin. Data were gathered by using face to face survey method and 165 company personnel have been surveyed. Hereby on country basis, opinions about what and how much is important for companies and personnels and how it supposed to be are received. As a conclusion, it was found out that there is a meaningful relationship between answers about the test standards in furniture sector in considering the age, educational level, positions in company and period of work in office of the company personne