gestantes UBS Perfil epidemiológico e sociodemográfico de gestantes em Vitória de Santo Antão/PE: Perfil epidemiológico e sociodemográfico de gestantes em Vitória de Santo Antão/PE

Objectives: To characterize and analyze the clinical and sociodemographic profile of pregnant women attended at Basic Health Units (UBS) covered by the Expanded Center for Family Health and Primary Care (NASF-AB) Lídia Queiroz in Vitória de Santo Antão/PE in 2020. Methods: Cross-sectional, descriptive and analytical study with a quantitative approach with secondary data from perinatal records and medical records of pregnant women attended at the health units covered in 2020. The data concern nutritional status, clinical conditions and sociodemographic aspects. Data analysis was performed by building a database in Microsoft Excel and statistical analysis using the IBM SPSS Statistic 25 program using the chi-square test of independence and independent T-test. Results: The Sample composed of 260 files and medical records with an average age between the units ranging from 21 to 25 years old. The chi-square test of independence between nutritional status and risk classification showed that there is an association between the development of high-risk pregnancy when the nutritional status is inadequate [x² (1)= 7.121a; p < 0.05]. The independent T-test showed that pregnant women with a lower level of education had a higher mean of unplanned pregnancy when compared to those with higher education [T (258) = 2.573; p < 0.05]. Conclusions: For this population, inadequate nutritional status influenced the increase in highrisk pregnancies, as well as conditions of social vulnerability can exert a risk factor for an unfavorable outcome for this woman and her family. Keywords:Primary Health Care; Righ risck pregnant; nutritional status; Social determinants of health; Public health.Objetivos: Caracterizar e analisar o perfil clínico e sociodemográfico de gestantes atendidas nas Unidades Básicas de Saúde (UBS) de cobertura do Núcleo de Ampliado de Saúde da Família e Atenção Básica (NASF-AB) Lídia Queiroz no município de Vitória de Santo Antão/PE em 2020. Métodos: Estudo transversal, descritivo e analítico com abordagem quantitativa a partir dedados secundários de fichas perinatais e prontuários de gestantes atendidas nas unidades de saúde cobertas em 2020. Os dados dizem respeito ao estado nutricional, condições clínicas e aspectos sociodemográficos. Após a construção de banco de dados no Microsoft Excel procedeu-se análise estatística pelo programa IBM SPSS Statistic 25 com utilização do teste qui- quadrado de independência e teste T- independente. Resultados: Amostra composta por 260 fichas e prontuários apresentando média de idade entre as unidades variando de 21 a 25 anos. O teste qui-quadrado de independência entre estado nutricional e classificação de risco mostrou que há associação entre desenvolvimento de gestação de alto risco quando o estado nutricional está inadequado [x² (1)= 7,121a; p < 0,05]. O teste T- independente mostrou que gestantes com menor grau de instrução apresentam maior média de gravidez não planejada quando comparada à de maior escolaridade [T (258) = 2,573; p < 0,05]. Considerações finais: Para essa população o estado nutricional inadequado representou influência no aumento de gestações de alto risco, assim como condições de vulnerabilidade social podem exercer um fator de risco para um desfecho desfavorável para essa mulher e sua família. Palavras-chave: Atenção Primária à saúde; Estado nutricional; Gravidez de alto risco; Determinantes sociais; Saúde pública

Nitric oxide monocyte production levels in patients with the hepatosplenic form of Scistosoma mansoni infection who underwent splenectomy, ligature of the left gastric vein and auto implantation of spleen tissue in the major omentum

PURPOSE: To measure the levels of NO production by monocytes in patients with the hepatosplenic form of schistosomiasis mansoni who underwent splenectomy, ligature of the left gastric vein and auto implantation of spleen tissue in the major omentum. METHODS: Four groups of volunteers were enrolled in the investigation: G1 - 12 patients with S. mansoni infection in its hepatosplenic form without any kind of treatment (SMH); G2 - 13 SMH patients who underwent medical treatment and portal hypertension decompression splenectomy and ligature of the left gastric vein (SMH/SLGV); G3 - 19 patients similar to the later group, but additionally received auto implantation of spleen morsels in the major omentum (SMH/SLGV/AI); and G4 - 15 individuals with no S. mansoni infection coming from the same geographical area and presenting similar socio economical status (CG). Nitrite production by monocytes was determined by a standard Griess reaction adapted to microplates. The results were presented by mean &plusmn; SD for each group. Significant differences in NO production by monocytes were determined by Tukey-Kramer multicomparisons test. Probability values of 0.05 were considered significant. RESULTS: Patients from G1 (SMH) showed lower level of NO production by monocytes (5.28 &plusmn; 1.28&micro;mol/ml). Patients from G2 (SMH/SLGV) showed similar results (6.67 &plusmn; 0.44&micro;mol/ml - q = 2.681 p > 0.05). Individuals of G4 (CG) showed higher level of NO production by monocytes (8.19 &plusmn; 2.74&micro;mol/ml). Patients from G3 (SMH/SGLV/AI) showed similar NO production by PBMC as compared to individuals of G4 (CG) - (7.41 &plusmn; 1.65&micro;mol/ml - q = 1.615 p > 0.05). The volunteers from G4 (CG) and G3 (SMH/SLGV/AI) showed significantly greater levels of NO production by monocytes as compared to those from G1 (SMH) - (q = 5.837 p < 0.01, and q = 4.285 p < 0.05). CONCLUSION: Collectively, the results point to a restoration of NO normal production by monocytes in SHM patients who underwent medical and surgical treatments, especially in those who had received auto implantation of spleen tissue in the major omentum after splenectomy and ligature of the left gastric vein. The data gives further support to the hypothesis that this additional procedure is important in the restoration of the immune response of these patients, since NO synthesis by the monocytes correlates with protective immunity against infection; thus, protecting them against overwhelming post splenectomy infection