"CMAD", a Full Custom ASIC, for the Upgrade of COMPASS RICH-1

An 8 channel, full-custom ASIC prototype, named ”CMAD”, designed for the readout of the RICH-I detector system of the COMPASS experiment at CERN is presented. The task of the chip is amplifying the signals coming from fast multi-anode photomultipliers and comparing them against a threshold adjustable on-chip on a channel by channel basis. CMAD, developed using a 350nm commercial CMOS technology, occupies an area of 4.7x3.2mm2 and consumes 26mW/Ch power from a 3.3 V single source

Melitopalynological and antimicrobial properties of honeys from elaziğ(e Turkey)

In this study, the pollen analyses and antimicrobial effect were conducted in honey samples, which were collected from seven localities where apiculture has intensively been practiced. Upon pollen analyses of 16 different plants have been determined. The plants contributing nectar to honey samples in Elazig were found as follows; Fabaceae: Astragalus, Trifolium, Vicia, Onobrychis; Asteraceae: Centaurea triumfettii, Carduus, Xeranthemum, Helianthus annuus; Lamiaceae: Salvia, Mentha;Rosaceae: Rubus, Prunus;Vitaceae: Vitaceae: Vitis;Apiaceae: Daucus; Zygophyllaceae: Peganum harmala; Ranunculaceae: Ranunculus. The honey sapmles have inhibited the growth of bacteria used in our work at varying degrees. None of the samples had any antifungal effect against Candida albicans FMC-17 and Saccharomycescerevisiae UAG-10

Anti-Tumor Efficacy of a Mesothelin-Based Nanovaccine in a KPC Orthotopic Mouse Model of Pancreatic Cancer

Background/Objectives: Immunotherapy has shown promising results in some cancers, but its efficacy remains limited in pancreatic ductal adenocarcinoma (PDAC). Vaccines in nanoparticle form (nanovaccines) can incorporate immunostimulating components to induce a potent immune response. As mesothelin (MSLN) is a tumor-associated antigen overexpressed in PDAC, we evaluated the effect of MSLN nanovaccine in a syngeneic orthotopic KPC-PDAC mouse model. Methods: An MSLN peptide combining three MSLN epitopes and two adjuvants, poly I:C and R848, was encapsulated in PLGA–chitosan nanoparticles to generate the nanovaccine. Results: The MSLN nanovaccine was successfully taken up by dendritic cells in vitro and was found in inguinal lymph nodes 24 h after subcutaneous injection into C57BL/6 mice. Nanovaccine re-stimulation of splenocytes from vaccinated mice led to increased levels of interferon-γ in vitro compared to unstimulated splenocytes. Higher levels of MSLN-specific IgM and IgG antibodies were detected in the serum of vaccinated mice compared to that of control mice. Three vaccination regimens were tested: a prophylactic scheme that included vaccination before tumor induction and two therapeutic schemes involving early and late vaccination after tumor cell inoculation. MSLN nanovaccination inhibited KPC tumor progression and metastasis and induced higher CD8+ T cell infiltration in the tumor that developed in response to prophylactic and early therapeutic schedules but not in response to a later vaccination approach. Although the nanovaccine treatment elicited higher humoral and cellular antigen-specific responses in tumor-bearing mice for both vaccination strategies, the therapeutic vaccination also increased the expression of exhaustion markers in CD8+ T cells. Conclusions: Our results support the relevance of an MSLN-based nanovaccine as a new immunotherapy treatment for PDAC and propose an innovative method of vaccine delivery using NPs

The effect of sleep and shift work on the primary immune response to messenger RNA-based COVID-19 vaccination

Shift work can cause circadian misalignment, which often results in sleeping problems and has been associated with immune dysfunction. To better understand the impact of shift work on a primary immune response to vaccination, we compared severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)-specific humoral and cellular immune responses after one injection of the messenger RNA (mRNA)-1273 vaccine between day workers (n = 24) and night shift workers (n = 21). In addition, duration and quality of sleep were assessed for a period of 7 days around the time of vaccination using actigraphy and daily sleep diaries, and their relationship with immunogenicity of mRNA-1273 vaccination was studied. We found that median total sleep time on the 2 days immediately after vaccination, which coincided with the days that night shift workers worked night shifts, was significantly lower in night shift workers (342 and 318 min) than day workers (431 and 415 min) (both p p = 0.013). Multivariate regression analysis showed no association between sleep duration, sleep quality and SARS-CoV-2-specific humoral or cellular immune responses. Collectively, these findings indicate that shift work-induced sleep loss and night shift work have little to no effect on the primary immune response to mRNA-based COVID-19 vaccination. Paroxysmal Cerebral Disorder

Essential plant nutrients and heavy metals concentrations of some medicinal and aromatic plants [Bazi{dotless} ti{dotless}bbi ve aromatik bitkilerin agi{dotless}r metal ve temel besin elementi İçerikleri]

In Turkey, the majority of medicinal plants at the selling points are wildly harvested. Therefore, no control exists during their growth and development. The public awareness on effects of environmental pollution in this regard especially with respect to heavy metals in the herbs is increasing. With this objective, medicinal and aromatic plants were collected from herbalists in different, densely populated districts of Izmir Municipality. The concentrations of some essential plant nutrient elements (N, P, K, Ca, Mg, Na, Fe, Mn, Cu, Zn, B, and Mo) and toxic heavy metals (Co, Cd, Cr, Ni, and Pb) and Al were measured. Results showed that herbs are rich in the investigated mineral elements; however, some of the heavy metals are found to be at concentrations above the reported critical levels. © Ankara Üniversitesi Ziraat Fakültesi

Effects of conventional and organic fertilizers on plant nutrition and essential oil components of basil

In this study, green herb and drug herb yields of basil (Ocimum basilicum L.) grown in organic and conventional farming systems were examined. Primary plant nutrients, total essential oil contents (%), and essential oil components were investigated as well. In the conventional system, nutrient inputs included 15.15.15 and monopotassium phosphate (MKP) fertilizers, and in the organic system, nutrient inputs included bone meal + zeolite (BM+Z) and rock phosphate + zeolite (RP+Z). For conventionally grown basil, the highest green herb yield was 1027.5 kg/da, and the highest drug herb yield was 191.1 kg/da. Green herb and drug herb yields were 872.6 kg/da in the MKP plots under conventional farming and 196.3 kg/da in the bone meal + zeolite plots under organic farming. Analysis of primary plant nutrients showed that nitrogen and magneslum contents in the 15.15.15 fertilizer plots and phosphorus, potassium, and calcium contents in the MKP plots were higher. Rock phosphate + zeolite was the forefront application in the organic fanning system. Essential oil yields were highest in the 15.15.15 treatment in the conventional farming system and in the control plot in the organic farming system. The most important essential oil component in both farming systems was linalool. © by PSP

New-onset type II diabetes mellitus, hyperosmolar non-ketotic coma, rhabdomyolysis and acute renal failure in a patient treated with sulpiride [5]

PubMed ID: 15735255[No abstract available

Geotechnical handicap of travertine with different lithotype levels as foundation material

Two major earthquakes occurred on October 23rd, 2011 (M= 7.1) and November 9th, 2011 (M= 5.6) in Tabanli and Edremit districts of Van province in Turkey, respectively. New settlement areas for Van city were determined after these destructive earthquakes. One of the most important areas for new settlements to be built was Edremit region, consisting travertine where nearly 80% of new housing units (12.384) were built by TOKI (Housing Development Administration of Turkey). Travertines have different lithotypes depending on their depositional process such as crystalline crust, shrub, reed which can affect mechanical and engineering properties of travertine and each level has different handicaps. The purpose of this study is to investigate the relationship between lithotype and physico-mechanical properties of travertines. According to the results, lithotype has an effect on physical, mechanical and rock mass properties of travertine. It is ascertained by several research methods that various handicaps may occur on such areas when the active tectonic structure of the area is evaluated along with the karstic cavities within the travertine and different lithotype qualities