Sivas yöresinde yaygın 20 uzun havanın analitik olarak incelenmesi

06.03.2018 tarihli ve 30352 sayılı Resmi Gazetede yayımlanan “Yükseköğretim Kanunu İle Bazı Kanun Ve Kanun Hükmünde Kararnamelerde Değişiklik Yapılması Hakkında Kanun” ile 18.06.2018 tarihli “Lisansüstü Tezlerin Elektronik Ortamda Toplanması, Düzenlenmesi ve Erişime Açılmasına İlişkin Yönerge” gereğince tam metin erişime açılmıştır

A Comparison of Ramipril and Bevacizumab to Mitigate Radiation-Induced Brain Necrosis: An Experimental Study

Background: Bevacizumab, an anti-vascular endothelial growth factor (VEGF) antibody, is a new treatment approach for radionecrosis. In our study, we compared the prophylactic and therapeutic usage of a promising agent, ramipril (an angiotensin-converting enzyme inhibitor), with that of bevacizumab for reducing radiation-induced brain injury after high-dose stereotactic radiosurgery (SRS). Methods: A total of 60 Wistar rats were used. The rats were irradiated with a single dose of 50 Gy using a Leksell Gamma Knife device. Bevacizumab and ramipril were administered in the prophylactic protocol (starting the first day of SRS) and in the therapeutic protocol (starting the fourth week of SRS). Their usage was continued until 12 weeks, and the right frontal lobes of the rats were examined histologically (hematoxylin and eosin stain) and immunohistochemically (hypoxia-inducible factor [HIF]-1α, VEGF, and CD31 antibody expression). Results: The expression of VEGF, HIF-1α, and CD31 had significantly increased at 12 weeks after SRS compared with the control group. The addition of bevacizumab or ramipril to SRS significantly mitigated the histological severity of radiation injury and the expression of VEGF, HIF-1α, and CD31. However, the prophylactic use of bevacizumab and ramipril seemed to be more effective than therapeutic administration. Our results also revealed that the greatest benefit was achieved with the use of prophylactic administration of bevacizumab compared with other treatment protocols. Conclusions: Ramipril might be a promising agent for patients with radionecrosis. Clinical studies are required to investigate the effective and safe doses of ramipril, which is an inexpensive, well-tolerated drug that can cross the blood–brain barrier. © 2020 Elsevier Inc

Uydu yönelim kontrolu için kontrol dağılım methodlarının geliştirilmesi.

This thesis addresses the attitude control of satellites with similar and dissimilar actuators and control allocation methods on maneuvering. In addition, the control moment gyro (CMG) steering with gyroscopes having limited gimbal angle travel is also addressed. Full Momentum envelopes for a cluster of four CMG's are obtained in a pyramid type mounting arrangement. The envelopes when gimbal travel is limited to plus-minus 90 degree are also obtained. The steering simulations using Moore Penrose (MP) pseudo inverse as well as blended inverse are presented and success of the pre planned blended inverse steering in avoiding gimbal angle limits is demonstrated through satellite slew maneuver simulations, showing the completion of the maneuver without violating gimbal angle travel restrictions. Dissimilar actuators, CMG and magnetic torquers are used as an approach of overactuated system. Steering simulations are carried out using different steering laws for constant torque and desired satellite slew maneuver scenarios. Success of the blended inverse steering algorithm over MP pseudo inverse is also demonstrated.M.S. - Master of Scienc

Testiste Spermatogenik Hücrelerde 1 İntegrin ve Fibronektin Dağılımı

Aim: Fibronectin interacts with its receptor, 1 integrin, and takes place in cell adhesion, migration and proliferation. In this study, we examined the distribution of fibronectin and 1 integrin developmental immunohistochemical methods. of testis tissues in different stages with Material and methods: Wistar rats were used in the study and divided into 8 groups according to their ages: newborn, 3 days, 10 days, 15 days, 21 days, 1 month, 2 months and adult. Testis immunohistochemically for fibronectin and tissue

Effects of Chemical Fruit Thinning on Oil Yield and Quality in ‘Gemlik’ Olive (Olea europaea L.)

‘Gemlik’ olive variety started to be grown in many areas of Turkey in recent years. ‘Gemlik’ is mainly a black table variety, but it is processed to oil in many areas.  So chemical fruit thinning may be useful to control alternate bearing and standardization of the fruit and consequently the oil quality. in this work, predicting the effects of chemical fruit thinning by potassium salt of naphtaleneacetic acid (NAA-K) on oil yield and quality in ‘Gemlik’, which is one of the prominent olive variety of Turkey was aimed. Results showed that NAA applications decreased the oil acidity levels in the first year (off year). in the second year (on year), NAA sprayings at 100 and 120 ppm increased the oil acidity up to 1.75 % while 150 ppm decreased the acidity value to 0.36 %. 180 ppm NAA significantly augmented the oil content of olive fruits particularly in “on year” and gave rise to 22 and 48 % increments in oil rates successively on fresh and dry matter basis compared to control.       ‘Gemlik’ olive variety started to be grown in many areas of Turkey in recent years. ‘Gemlik’ is mainly a black table variety, but it is processed to oil in many areas.  So chemical fruit thinning may be useful to control alternate bearing and standardization of the fruit and consequently the oil quality. in this work, predicting the effects of chemical fruit thinning by potassium salt of naphtaleneacetic acid (NAA-K) on oil yield and quality in ‘Gemlik’, which is one of the prominent olive variety of Turkey was aimed. Results showed that NAA applications decreased the oil acidity levels in the first year (off year). in the second year (on year), NAA sprayings at 100 and 120 ppm increased the oil acidity up to 1.75 % while 150 ppm decreased the acidity value to 0.36 %. 180 ppm NAA significantly augmented the oil content of olive fruits particularly in “on year” and gave rise to 22 and 48 % increments in oil rates successively on fresh and dry matter basis compared to control.      

Immunohistochemical evaluation of the distribution of laminin, fibronectin and type IV collagen in sciatic nerves of streptozotocine-induced diabetic rats

Amaç: Bu çalışmada, diyabetik sıçanlarda periferik sinir hücre dışı matriks proteinlerinin (laminin, fibronektin, tipIV kollajen) dağılımlarını immunohistokimyasal yöntemlerle inceledik. Gereç ve Yöntem: 250 - 300 g ağırlığında, erişkin erkek Wistar Albino sıçanlardan kontrol (n=10) ve diyabetik (n=10) gruplar oluşturuldu. Alınan sinir dokularına fibronektin, laminin ve tip IV kollajen için immunohistokimyasal inceleme yapıldı. Bulgular: Fibronektin ve laminin tutulumunun kontrol grubuna oranla artığını, tutulumların özellikle perinöryumda, Schwann hücre ve endonöral kân damarları çevresinde yoğunlaştığı izlendi. Fibronektin tutulumu perinöryumun en iç katında çok zayıfken, laminin tutulumu özellikle burada çok artmıştı. Ayrıca Tip IV kollajen tutulumunun da aynı alanlarda daha fazla olduğu ama kontrollerle arasında belirgin bir farklılık olmadığı görüldü. Sonuç: Bu bulguların ışığında diyabetin hücre dışı matriks bileşenlerinin ekspresyonunu arttırabileceği ama diğer yandan diyabetin bu bileşenlerin yapısınıbozarak immunohistokimyasal çalışmalarda antikor tutulumunu engelleyebileceği düşünülmektedir.Immunohistochemical evaluation of the distribution of laminin, fibronectin and type IV collagen in sciatic nerves of Streptozotocine-induced diabetic rats Objective: The immunohistochemical distribution of type IV collagen, fibronectin and laminin in peripheral nerves of STZ diabetic rats were studied in the present study. Methods: 2 groups were formed as control and diabetic with 20 Wistar Albino rats (10 rats in each) weighing 250 - 300 g. Sciatic nerves were excised and stained immunohistochemically with laminin, fibronectin and type IV collagen antibodies. Results: We found that increased deposition of type IV collagen, fibronectin and laminin was observed in the perineurium, and endoneurium surrounding microvessels and Schwann cells. Fibronectin and laminin immune reactions were slightly stronger in diabetic nerves. Laminin expression was most evident in the innermost layers of perineurium. But interestingly, there was almost no fibronectin expression in the same layers. Type IV collagen expression in diabetics didn't obviously differ from that in controls. Conclusion: We concluded that diabetes mellitus might increase the expression of extracellular matrixcomponents. But diabetes could also destroy the structure of these proteins and prevent them from binding immunohistochemical antibodies leading to diminished staining

The Effects of Riluzole on Cisplatin-induced Ototoxicity.

Introduction  Riluzole (2-amino-6-trifluoromethoxy benzothiazole) is known as a neuroprotective, antioxidant, antiapoptotic agent. It may have beneficial effects on neuronal cell death due to cisplatin-induced ototoxicity. Objective  To evaluate the effect of riluzole on cisplatin-induced ototoxicity in guinea pigs. Methods  Twenty-four guinea pigs, studied in three groups, underwent auditory brainstem response evaluation using click and 8 kHz tone burst stimuli. Subsequently, 5 mg/kg of cisplatin were administered to all animals for 3 days intraperitoneally (i.p.) to induce ototoxicity. Half an hour prior to cisplatin, groups 1, 2 and 3 received 2 ml of saline i.p., 6 mg/kg of riluzole hydrochloride i.p., and 8 mg/kg of riluzole hydrochloride i.p., respectively, for 3 days. The auditory brainstem responses were repeated 24 hours after the last drug administration. The cochleae were analyzed by transmission electron microscopy (TEM). Results  After drug administiration, for 8,000 Hz stimulus, group 1 had significantly higher threshold shifts when compared with groups 2 ( p   0.05). Transmission electron microscopy findings demonstrated the protective effect of riluzole on the hair cells and the stria vascularis, especially in the group treated with 8 mg/kg of riluzole hydrochloride. Conclusion  We can say that riluzole may have a protective effect on cisplatin- induced ototoxicity. However, additional studies are needed to confirm these results and the mechanisms of action of riluzole