Frontal sinüs boyutlarının yaş ve cinsiyet ile ilişkisinin değerlendirilmesi

Amaç: Adli araştırmaların önemli bir parçası bireyin kimliklendirilmesidir. Frontal sinüs, kişisel tanımlama, yaş tahmini ve cinsiyet tayini için değerli özelliklere sahiptir. Bu çalışmada amaç konik ışınlı bilgisayarlı tomografi (KIBT) görüntülerinde frontal sinüs boyutlarını değerlendirerek, bu boyutların yaş ile ilişkisini ve cinsiyet tayinindeki önemini belirlemektir.Gereç ve Yöntemler: Yaşları 20 ile 85 arasında değişen toplam 178 birey (105 Kadın, 73 Erkek) retrospektif olarak incelendi. KIBT görüntülerinde her sinüs için sağ ve sol taraf olmak üzere genişlik, yükseklik ve anteroposterior derinlik ve maksimum toplam genişlik ölçümleri yapıldı. Çalışmaya dahil olan bireyler yaşa göre 5 alt gruba ayrıldı ve her ölçüm parametresi de alt gruplar arasında karşılaştırıldı. Toplanan verilerin istatistiksel analizi Statistical Package for the Social Sciences (SPSS) 23.0 programı kullanılarak yapıldı.Bulgular: Sağ ve sol frontal sinüs genişliği, anteroposterior derinlik ve maksimum toplam genişlik özellikleri açısından erkekler kadınlardan istatistiksel olarak önemli derecede yüksek ortalamalara sahipken (p<0.01), sinüs yüksekliği açısından istatistiksel olarak önemli bir fark belirlenmedi. Değerlendirilen tüm parametreler için yaş grupları arasında istatistiksel olarak önemli bir fark gözlenmedi. Yapılan diskriminant analizi sonucu cinsiyet tahmininde doğruluk oranı % 71.3 olarak hesaplandı.Sonuç: Bu çalışmada KIBT görüntülerinde ölçülen frontal sinüs boyutlarının yaş grupları arasında önemli farklılık göstermediği belirlendi. Bununla birlikte frontal sinüsün cinsiyet tayininde dimorfik özellikte olduğu fakat tek başına cinsiyet belirlemede yeterli olmadığı ve ilave parametrelerle doğruluğunun artırılacağı düşünüldü.ANAHTAR KELİMELER Adli bilimler, Cinsiyet tespiti analizi, Frontal sinus, Konik ışınlı bilgisayarlı tomograf

Mavi devrim : Devrim Erbil

Ankara : İhsan Doğramacı Bilkent Üniversitesi İktisadi, İdari ve Sosyal Bilimler Fakültesi, Tarih Bölümü, 2017.This work is a student project of the The Department of History, Faculty of Economics, Administrative and Social Sciences, İhsan Doğramacı Bilkent University.by Yiğit, Tarık Tansu

Cumhuriyetin ilanından sonra Romanya'dan Türkiye'ye gelen göçmenler

Ankara : İhsan Doğramacı Bilkent Üniversitesi İktisadi, İdari ve Sosyal Bilimler Fakültesi, Tarih Bölümü, 2017.This work is a student project of the The Department of History, Faculty of Economics, Administrative and Social Sciences, İhsan Doğramacı Bilkent University.by Mercan, Fatma Özden

20. yy. Balkan göçü

Ankara : İhsan Doğramacı Bilkent Üniversitesi İktisadi, İdari ve Sosyal Bilimler Fakültesi, Tarih Bölümü, 2014.This work is a student project of the The Department of History, Faculty of Economics, Administrative and Social Sciences, İhsan Doğramacı Bilkent University.by Ünsal, Mehmet Süha

Ellagic acid for oral mucositis: investigation of the therapeutic effect in rats

AbstractThe aim of this study was to evaluate the effect of ellagic acid on 5-fluorouracil-induced oral mucositis in rats. Twenty-four 6-month-old male Wistar albino rats were used. The rats were divided into three groups: Experimental Group I, Experimental Group II and Control Group. A superficial scratch was made on the mucosa of the right cheek pouch on the 3rd day and the 5th day. Oral mucositis protocol was applied to the Control Group. Ellagic acid was administered by gavage to the Experimental Group I from the 1st day to the 5th day along with the 5-FU procedure, and to the Experimental Group II from the 5th day to the 10th day. On the 11th day, all rats were sacrificed. The effect of ellagic acid on the healing of oral mucositis was evaluated histopathologically and immunohistochemically. TNF-α expression was observed at various intensities in the infected incision sites of the Experimental Group I sample, especially in the interstitial area in the lamina propria and mostly in the cytoplasm of the inflammatory cells within the vessel. Similar to the Experimental Group I, TNF-α expression of varying intensity occurred in the inflammatory cells in the Experimental Group II, partly in the epithelium and mostly in the inflammatory cells in the lamina propria. Additional research is needed to elucidate the pathogenic inflammatory mechanisms involved in the mucositis site and the prophylactic and therapeutic roles of antioxidants in the healing of oral mucositis by ellagic acid

Whole-Exome Sequencing (WES) results of 50 patients with chronic kidney diseases: a perspective of Alport syndrome

OBJECTIVE: Chronic kidney disease (CKD) remains one of the major common health problems, and the number of people affected by the disease is progressively increasing in Turkey and worldwide. This study aimed to investigate molecular defects in Alport syndrome (AS) and other genes in patients with clinically suspected CKD using whole-exome sequencing (WES).METHODS: Patients with clinical suspicion of CKD were included in the study. Molecular genetic analyses were performed on genomic DNA by using WES.RESULTS: A total of 15 with 5 different pathogenic or likely pathogenic variants were identified in CKD patients, with a diagnostic rate of 30%. Eight variants of uncertain significance were also detected. In this study, 10 variants were described for the first time. As a result, we detected variants associated with CKD in our study population and found AS as the most common CKD after other related kidney diseases.CONCLUSIONS: Our results suggest that in heterogeneous diseases such as CKD, WES analysis enables accurate identification of underlying molecular defects promptly. Although CKD accounts for 10-14% of all renal dysfunction, molecular genetic diagnosis is necessary for optimal long-term treatment, prognosis, and effective genetic counseling

Suboptimal use of non-vitamin K antagonist oral anticoagulants: Results from the RAMSES study

WOS: 000384041400052PubMed ID: 27583892This study aimed to investigate the potential misuse of novel oral anticoagulants (NOACs) and the physicians' adherence to current European guideline recommendations in real-world using a large dataset from Real-life Multicenter Survey Evaluating Stroke Prevention Strategies in Turkey (RAMSES Study).RAMSES study is a prospective, multicenter, nationwide registry (ClinicalTrials.gov identifier NCT02344901). In this subgroup analysis of RAMSES study, patients who were on NOACs were classified as appropriately treated (AT), undertreated (UT), and overtreated (OT) according to the European Society of Cardiology (ESC) guidelines. The independent predictors of UT and OT were determined by multivariate logistic regression.Of the 2086 eligible patients, 1247 (59.8%) received adequate treatment. However, off-label use was detected in 839 (40.2%) patients; 634 (30.4%) patients received UT and 205 (9.8%) received OT. Independent predictors of UT included >65 years of age, creatinine clearance 50mL/min, urban living, existing dabigatran treatment, and HAS-BLED score of <3, whereas that of OT were creatinine clearance <50mL/min, ongoing rivaroxaban treatment, and HAS-BLED score of 3.The suboptimal use of NOACs is common because of physicians' poor compliance to the guideline recommendations in patients with nonvalvular atrial fibrillation (NVAF). Older patients who were on dabigatran treatment with good renal functions and low risk of bleeding were at risk of UT, whereas patients who were on rivaroxaban treatment with renal impairment and high risk of bleeding were at risk of OT. Therefore, a greater emphasis should be given to prescribe the recommended dose for the specified patients