Synthesis and preliminary mechanistic evaluation of 5-(p-tolyl)-1-(quinolin-2-yl)pyrazole-3-carboxylic acid amides with potent antiproliferative activity on human cancer cell lines

We synthesized a series of novel amide derivatives of 5-(p-tolyl)-1-(quinolin-2-yl)pyrazole-3-carboxylic acid and assessed their antiproliferative activities against three human cancer cell lines (Huh7, human liver; MCF7, breast and HCT116, colon carcinoma cell lines) with the sulforhodamine B assay. Compound 4j with 2-chloro-4-pyridinyl group in the amide part exhibited promising cytotoxic activity against all cell lines with IC50values of 1.6 μM, 3.3 μM and 1.1 μM for Huh7, MCF7 and HCT116 cells, respectively, and produced dramatic cell cycle arrest at SubG1/G1 phase as an indicator of apoptotic cell death induction. On the basis of their high potency in cellular environment, these straightforward pyrazole-3-carboxamide derivatives may possess potential in the design of more potent compounds for intervention with cancer cell proliferation. © 2014 Elsevier Masson SAS

On finiteness conditions for S, ? and S/?

Let S be a semigroup and let p be a congruence on S. We consider ? as a subsemigroup of the direct product S × S. Then we prove that ? is periodic, locally finite and residually finite if and only if S is periodic, locally finite and residually finite, respectively. Moreover, ? has a solvable word problem if and only if S has a solvable word problem. © 2010, Academic Publications Ltd

Semigroup presentations for congruences on groups

We consider a congruence ? on a group G as a subsemigroup of the direct product G × G. It is well known that a relation ? on G is a congruence if and only if there exists a normal subgroup N of G such that ? = {(s, t): st-1 {small element of} N}. In this paper we prove that if G is a finitely presented group, and if N is a normal subgroup of G with finite index, then the congruence ? = {(s, t): st-1 ? N} on G is finitely presented. © 2013 The Korean Mathematical Society

Criteria Assessment Questionnaire

Railway System Alignment/Station Area Selection Criteria Comparison MCDM/MCDA methods are an important support tool in solving various decision-making problems in the field of transport, especially in the field of safety and quality of public transport, selection of development scenarios for public transport systems, location analyses of transport projects, as well as in other problems related to broadly understood road, air, rail and sea transport. This survey mainly focusing on ‘Railway System Alignment/Station Area Selection Criteria Comparison’ which would be a resource for acquiring influence weights for overlaying map layers which is the section of my PhD thesis

Stream Modelbuilder toolbox

Modelbuilder toolbox for Stream Mode

Buffer Analysis

Buffer analysis is used for generating a 1000 m buffer zone around 8 rail station points

Fuzzy Logic Designer_Berna

Suitability.m, Suitability.fig, Suitability.fisTHIS DATASET IS ARCHIVED AT DANS/EASY, BUT NOT ACCESSIBLE HERE. TO VIEW A LIST OF FILES AND ACCESS THE FILES IN THIS DATASET CLICK ON THE DOI-LINK ABOV

Geological Suitability

Lithologic segmentation process carried out by drawing poligon lines from the boundary lines manually. After creating and editing poligon_jeo shape file, type and quality score of lithologic formation data entere

Slope

‘Slope model’ is generated from the digital elevation map (DEM)