The effects of different concentrations of the α2-Adrenoceptor Agonist Medetomidine on basal excitatory synaptic transmission and synaptic plasticity in hippocampal slices of adult mice

α2-Adrenoceptor agonists are used frequently in human and veterinary anesthesia as sedative/analgesic drugs. However, they can impair cognition. Little is known about the concentration-dependent effects of α2-adrenoceptor agonists on synaptic plasticity, the neurophysiological basis of learning and memory. Therefore, we investigated the effects of different concentrations of medetomidine, an α2-adrenoceptor agonist, on basal excitatory synaptic transmission and on 2 forms of synaptic plasticity: paired-pulse facilitation (PPF) and long-term potentiation (LTP).Funding: This work was supported by FCT (Lisbon, Portugal) and cofunded by COMPETE: 01-0124-FEDER-009497 (Lisbon, Portugal), through the project grants PTDC/CVT/099022/2008 and PTDC/SAU-NSC/122254/2010 and through a personal PhD grant (SFRH /BD/48883/2008) to Patrícia do Céu Oliveira Ribeiro and by QREN (09-68-ESR-FP-010).info:eu-repo/semantics/publishedVersio

Assessment of chemical hazards in insect meal production for aquaculture feeds

Abstract of communication presented at the 74th EAAP International Congress on Animal Science. Lyon, France, 26 August-1 September 2023N/

Guarana (Paullinia cupana var. sorbilis), an anciently consumed stimulant from the Amazon rain forest: the seeded-fruit transcriptome.

Guarana (Paullinia cupana var. sorbilis) is a plant native to the central Amazon basin. Roasted seed extracts have been used as medicinal beverages since pre-Colombian times, due to their reputation as stimulants, aphrodisiacs, tonics, as well as protectors of the gastrointestinal tract. Guarana plants are commercially cultivated exclusively in Brazil to supply the national carbonated soft-drink industry and natural product stores around the world. In this report, we describe and discuss the annotation of 15,387 ESTs from guarana seeded-fruits, highlighting sequences from the flavonoid and purine alkaloid pathways, and those related to biotic stress avoidance. This is the largest set of sequences registered for the Sapindaceae family

Avaliação da coleção de Mentha sp. da Embrapa Recursos Genéticos e Biotecnologia nas condições de Manaus-AM.

O objetivo deste trabalho foi avaliar agronomicamente o potencial de 67 acessos de Menta bem como a produção de compostos biologicamente ativos na Embrapa Amazônia Ocidental (região ecofisiográfica de Manaus-AM)

Produção de polibenzoxazina a partir da lignina do bagaço da cana-de-açúcar.

Este Comunicado Técnico visa apresentar um processo para produção de uma resina benzoxazina, em escala de laboratório, a partir da lignina extraída do bagaço da cana-de-açúcar.bitstream/item/206830/1/CT-261.pd