The Interplay between Microbiota and Chemotherapy-Derived Metabolites in Breast Cancer

UGR Plan Propio de Investigación 2016” and the “Excellence Actions: Unit of Excellence in Exercise and Health (UCEES), University of Granada”Postdoctoral contract (RPS 24665, 2021) from Consejería de Salud y Familias, Junta de Andalucía, Spain)

Dietary Polysaccharides as Modulators of the Gut Microbiota Ecosystem: An Update on Their Impact on Health

A polysaccharide is a macromolecule composed of more than ten monosaccharides with a wide distribution and high structural diversity and complexity in nature. Certain polysaccharides are immunomodulators and play key roles in the regulation of immune responses during the progression of some diseases. In addition to stimulating the growth of certain intestinal bacteria, polysaccharides may also promote health benefits by modulating the gut microbiota. In the last years, studies about the triad gut microbiota–polysaccharides–health have increased exponentially. In consequence, in the present review, we aim to summarize recent knowledge about the function of dietary polysaccharides on gut microbiota composition and how these effects affect host health.Regional Ministry of Health and Families (Andalucia, Spain)CSyF 2021-Postdoctoral RPS 24665"Fundacion Ramon Areces", Madrid, Spai

Dietary Polysaccharides and Gut Microbiota Ecosystem

The intestinal microbiota is a community of microorganisms that subsists within the gastrointestinal ecosystem. In human health, the role of the gastrointestinal microbiota is to maintain a dynamic balance with the host. This balance plays both local and remote roles in critical physiological processes, particularly inflammation, and the immune response [1]. Natural polysaccharides are polymeric carbohydrate macromolecules and sources of fermentable dietary fiber. Polysaccharides are the most abundant dietary components in the gut microbiota and are deeply involved in host health [2]. Emerging evidence shows the involvement of polysaccharides in numerous functions in gut microbiota-host symbiosis, such as microbial interactions with endogenous host glycans, and the key role of microbial polysaccharides [3]. Additionally, bacterial polysaccharides act as immunomodulators, and host-derived polysaccharides protect host cells from pathogenic microbial neighbors and affect overall gut health through interactions with gut microbes. The growth of certain beneficial intestinal bacteria can be promoted by polysaccharides (among other things) during intestinal fermentation, changing the microbiota profile of the gut and altering both local and remote host physiology, which can reduce disease development [3,4]

Editorial: Molecular and cellular aspects of regulatory and subjacent mechanisms in host/ microbiota association and its involvement in cancer

Editorial on the Research Topic: Molecular and cellular aspects of regulatory and subjacent mechanisms in host/microbiota association and its involvement in cancerRegional Ministry of Health and Families (Andalucia, Spain). CSyF 2021-Postdoctoral RPS 24665"Fundacion Ramon Areces," Madrid, Spai

Estructura territorial y relaciones funcionales en el Corredor del Henares: una aproximación desde la movilidad diaria de la población

«Territorial structure and functional relations in the Henares Corridor: an approach from the daily population mobility». This article attempts to study the recent evolution of the population daily mobility with the goal of identifying the possible changes in the dependence relations of Henares Corridor with regard to the capital of Madrid, as well as recognizing the possible configuration of a functional sub-region between the municipalities. We began with the hypothesis that the recent organization of residential and productive spaces —specially manifesting in the outskirt of the metropolitan area of Madrid— has affected such relations. For this study we part from the information provided by the Domiciliary Mobility Surveys done by the Regional Transport Consortium of Madrid in 1988 and 1996.En este artículo se pretende estudiar la evolución reciente de la movilidad diaria de la población con el fin de identificar los posibles cambios en las relaciones de dependencia del Corredor del Henares respecto a Madrid capital, y también reconocer la posible configuración de una subregión funcional entre los municipios que lo componen. Se parte de la hipótesis de que los recientes procesos de reorganización de los espacios residenciales y productivos, especialmente manifiestos en las periferias del área metropolitana de Madrid, han afectado a dichas relaciones. El estudio se basa en la información proporcionada por las Encuestas Domiciliarias de Movilidad realizadas por el Consorcio Regional de Transportes de Madrid en 1988 y 1996

Mesoporous silicas with tunable morphology for the immobilization of laccase

Siliceous ordered mesoporous materials (OMM) are gaining interest as supports for enzyme immobilization due to their uniform pore size, large surface area, tunable pore network and the introduction of organic components to mesoporous structure. We used SBA-15 type silica materials, which exhibit a regular 2D hexagonal packing of cylindrical mesopores of uniform size, for non-covalent immobilization of laccase. Synthesis conditions were adjusted in order to obtain supports with different particle shape, where those with shorter channels had higher loading capacity. Despite the similar isoelectric points of silica and laccase and the close match between the size of laccase and the pore dimensions of these SBA-15 materials, immobilization was achieved with very low leaching. Surface modification of macro-/mesoporous amorphous silica by grafting of amine moieties was proved to significantly increase the isoelectric point of this support and improve the immobilization yield. © 2014 by the authors.The authors thank the Spanish Government for financial support through the project MAT 2012-31127, and Ramiro Martinez (Novozymes, Spain) for his kind help with the supply of laccase. V. G. acknowledges Ministerio de Educación, Cultura y Deporte for a FPU PhD fellowship. We acknowledge support by the CSIC Open Access Publication Initiative through its Unit of Information Resources for Research (URICI)Peer Reviewe

Nutrition and cellular senescence in obesity-related disorders

Julio Plaza-Diaz is part of the “UGR Plan Propio de Investigación 2016 and the “Excellence actions: Unit of Excellence on Exercise and Health (UCEES), University of Granada”. Julio Plaza-Diaz is sup- ported by a grant awarded to postdoctoral researchers at foreign universities and research centers from the “Fundación Ramón Are- ces”, Madrid, Spain. Funding for open access charge: Universidad de Granada / CBUA.Adequate nutrition is vital for immune homeostasis. However, the incidence of obesity is increasing worldwide due to the adoption of the Western diet and a sedentary lifestyle. Obesity is associated with chronic inflammation which alters the function of adipose tissue, liver, pancreas, and the nervous system. Inflammation is related to cellular senescence, distinguished by irreversible cell cycle arrest. Senescent cells secrete the senescence-associated secretory phenotype (SASP) which contains pro-inflammatory factors. Targeting processes in senescence might have a salutary approach to obesity. The present review highlights the impact of an unhealthy diet on tissues affected by obesity, and the mechanisms that promote the consequent inflammation and senescence.UGR Plan Propio de Investigación 2016Excellence actions: Unit of Excellence on Exercise and Health (UCEES), University of Granada“Fundación Ramón Are- ces”, Madrid, Spain.Universidad de Granada / CBU

La contabilidad analítica como herramienta de información para la transparencia y la toma de decisiones: un itinerario para el análisis de costes

El presente trabajo pretender ofrecer una propuesta metodológica para la elaboración de informes analíticos sobre los resultados obtenidos a partir de la personalización del Modelo de Contabilidad Analítica del Ministerio de Educación, Cultura y Deporte del Reino de España (en adelante MECD) y cálculo de costes en las Universidades Públicas Españolas de acuerdo a los principios que contiene.El presente trabajo pretender ofrecer una propuesta metodológica para la elaboración de informes analíticos sobre los resultados obtenidos a partir del cálculo de costes en las Universidades Públicas Españolas de acuerdo a los principios del Modelo de Contabilidad Analítica del Ministerio de Educación, Cultura y Deporte. A tales efectos, el trabajo realizado aborda el estudio y análisis valorativo de las herramientas que definen la metodología propuesta (análisis de pesos relativos, análisis de promedios y medianas, estudio de desviaciones y variaciones, identificación de anomalías,…), para alcanzar los fines anteriormente descritos, formulando el esbozo de la cartografía de una metodología específica para facilitar la interpretación y la obtención de conclusiones sobre los resultados del ModeloUniversidad de Málaga. Campus de Excelencia Internacional Andalucía Tech