6 research outputs found

    Comment on "Modified Coulomb Law in a Strongly Magnetized Vacuum"

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    This is a comment on Phys. Rev. Lett. 98, 180403 (2007) [arXiv:0704.2162].Comment: 1 page, comment on arXiv:0704.2162, published versio

    A multimodal cell census and atlas of the mammalian primary motor cortex

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    ABSTRACT We report the generation of a multimodal cell census and atlas of the mammalian primary motor cortex (MOp or M1) as the initial product of the BRAIN Initiative Cell Census Network (BICCN). This was achieved by coordinated large-scale analyses of single-cell transcriptomes, chromatin accessibility, DNA methylomes, spatially resolved single-cell transcriptomes, morphological and electrophysiological properties, and cellular resolution input-output mapping, integrated through cross-modal computational analysis. Together, our results advance the collective knowledge and understanding of brain cell type organization: First, our study reveals a unified molecular genetic landscape of cortical cell types that congruently integrates their transcriptome, open chromatin and DNA methylation maps. Second, cross-species analysis achieves a unified taxonomy of transcriptomic types and their hierarchical organization that are conserved from mouse to marmoset and human. Third, cross-modal analysis provides compelling evidence for the epigenomic, transcriptomic, and gene regulatory basis of neuronal phenotypes such as their physiological and anatomical properties, demonstrating the biological validity and genomic underpinning of neuron types and subtypes. Fourth, in situ single-cell transcriptomics provides a spatially-resolved cell type atlas of the motor cortex. Fifth, integrated transcriptomic, epigenomic and anatomical analyses reveal the correspondence between neural circuits and transcriptomic cell types. We further present an extensive genetic toolset for targeting and fate mapping glutamatergic projection neuron types toward linking their developmental trajectory to their circuit function. Together, our results establish a unified and mechanistic framework of neuronal cell type organization that integrates multi-layered molecular genetic and spatial information with multi-faceted phenotypic properties

    Atomistic Simulation of Nanoindentation

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    [[sponsorship]]U.S. National Congress on Computational Mechanics[[conferencetype]]朋際[[conferencedate]]20070723~20070727[[booktype]]çŽ™æœŹ[[iscallforpapers]]Y[[conferencelocation]]San Francisco, CA, US

    Search for anomaly-mediated supersymmetry breaking with the ATLAS detector based on a disappearing-track signature in pp collisions at sqrt(s) = 7TeV$

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    none3019G. Aad;B. Abbott;J. Abdallah;A. A. Abdelalim;A. Abdesselam;O. Abdinov;B. Abi;M. Abolins;H. Abramowicz;H. Abreu;E. Acerbi;B. S. Acharya;D. L. Adams;T. N. Addy;J. Adelman;M. Aderholz;S. Adomeit;P. Adragna;T. Adye;S. Aefsky;J. A. Aguilar-Saavedra;M. Aharrouche;S. P. Ahlen;F. Ahles;A. Ahmad;M. Ahsan;G. Aielli;T. Akdogan;T. P. A. Åkesson;G. Akimoto;A. V. Akimov;A. Akiyama;M. S. Alam;M. A. Alam;J. Albert;S. Albrand;M. Aleksa;I. N. Aleksandrov;F. Alessandria;C. Alexa;G. Alexander;G. Alexandre;T. Alexopoulos;M. Alhroob;M. Aliev;G. Alimonti;J. Alison;M. Aliyev;P. P. Allport;S. E. Allwood-Spiers;J. Almond;A. Aloisio;R. Alon;A. Alonso;B. Alvarez Gonzalez;M. G. Alviggi;K. Amako;P. Amaral;C. Amelung;V. V. Ammosov;A. Amorim;G. AmorĂłs;N. Amram;C. Anastopoulos;L. S. Ancu;N. Andari;T. Andeen;C. F. Anders;G. Anders;K. J. Anderson;A. Andreazza;V. Andrei;M-L. Andrieux;X. S. Anduaga;A. Angerami;F. Anghinolfi;A. Anisenkov;N. Anjos;A. Annovi;A. Antonaki;M. Antonelli;A. Antonov;J. Antos;F. Anulli;S. Aoun;L. Aperio Bella;R. Apolle;G. Arabidze;I. Aracena;Y. Arai;A. T. H. Arce;J. P. Archambault;S. Arfaoui;J-F. Arguin;E. Arik;M. Arik;A. J. Armbruster;O. Arnaez;C. Arnault;A. Artamonov;G. Artoni;D. Arutinov;S. Asai;R. Asfandiyarov;S. Ask;B. Åsman;L. Asquith;K. Assamagan;A. Astbury;A. Astvatsatourov;B. Aubert;E. Auge;K. Augsten;M. Aurousseau;G. Avolio;R. Avramidou;D. Axen;C. Ay;G. Azuelos;Y. Azuma;M. A. Baak;G. Baccaglioni;C. Bacci;A. M. Bach;H. Bachacou;K. Bachas;G. Bachy;M. Backes;M. Backhaus;E. Badescu;P. Bagnaia;S. Bahinipati;Y. Bai;D. C. Bailey;T. Bain;J. T. Baines;O. K. Baker;M. D. Baker;S. Baker;E. Banas;P. Banerjee;Sw. Banerjee;D. Banfi;A. Bangert;V. Bansal;H. S. Bansil;L. Barak;S. P. Baranov;A. Barashkou;A. Barbaro Galtieri;T. Barber;E. L. Barberio;D. Barberis;M. Barbero;D. Y. Bardin;T. Barillari;M. Barisonzi;T. Barklow;N. Barlow;B. M. Barnett;R. M. Barnett;A. Baroncelli;G. Barone;A. J. Barr;F. Barreiro;J. Barreiro GuimarĂŁes da Costa;P. Barrillon;R. Bartoldus;A. E. 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Bini;C. Biscarat;U. Bitenc;K. M. Black;R. E. Blair;J.-B. Blanchard;G. Blanchot;T. Blazek;C. Blocker;J. Blocki;A. Blondel;W. Blum;U. Blumenschein;G. J. Bobbink;V. B. Bobrovnikov;S. S. Bocchetta;A. Bocci;C. R. Boddy;M. Boehler;J. Boek;N. Boelaert;S. Böser;J. A. Bogaerts;A. Bogdanchikov;A. Bogouch;C. Bohm;V. Boisvert;T. Bold;V. Boldea;N. M. Bolnet;M. Bona;V. G. Bondarenko;M. Bondioli;M. Boonekamp;G. Boorman;C. N. Booth;S. Bordoni;C. Borer;A. Borisov;G. Borissov;I. Borjanovic;S. Borroni;K. Bos;D. Boscherini;M. Bosman;H. Boterenbrood;D. Botterill;J. Bouchami;J. Boudreau;E. V. Bouhova-Thacker;C. Bourdarios;N. Bousson;A. Boveia;J. Boyd;I. R. Boyko;N. I. Bozhko;I. Bozovic-Jelisavcic;J. Bracinik;A. Braem;P. Branchini;G. W. Brandenburg;A. Brandt;G. Brandt;O. Brandt;U. Bratzler;B. Brau;J. E. Brau;H. M. Braun;B. Brelier;J. Bremer;R. Brenner;S. Bressler;D. Breton;D. Britton;F. M. Brochu;I. Brock;R. Brock;T. J. Brodbeck;E. Brodet;F. Broggi;C. Bromberg;J. Bronner;G. Brooijmans;W. K. Brooks;G. Brown;H. Brown;P. A. Bruckman de Renstrom;D. Bruncko;R. Bruneliere;S. Brunet;A. Bruni;G. Bruni;M. Bruschi;T. Buanes;Q. Buat;F. Bucci;J. Buchanan;N. J. Buchanan;P. Buchholz;R. M. Buckingham;A. G. Buckley;S. I. Buda;I. A. Budagov;B. Budick;V. BĂŒscher;L. Bugge;D. Buira-Clark;O. Bulekov;M. Bunse;T. Buran;H. Burckhart;S. Burdin;T. Burgess;S. Burke;E. Busato;P. Bussey;C. P. Buszello;F. Butin;B. Butler;J. M. Butler;C. M. Buttar;J. M. Butterworth;W. Buttinger;S. Cabrera UrbĂĄn;D. Caforio;O. Cakir;P. Calafiura;G. Calderini;P. Calfayan;R. Calkins;L. P. Caloba;R. Caloi;D. Calvet;S. Calvet;R. Camacho Toro;P. Camarri;M. Cambiaghi;D. Cameron;L. M. Caminada;S. Campana;M. Campanelli;V. Canale;F. Canelli;A. Canepa;J. Cantero;L. Capasso;M. D. M. Capeans Garrido;I. Caprini;M. Caprini;D. Capriotti;M. Capua;R. Caputo;C. Caramarcu;R. Cardarelli;T. Carli;G. Carlino;L. Carminati;B. Caron;S. Caron;G. D. Carrillo Montoya;A. A. Carter;J. R. Carter;J. Carvalho;D. Casadei;M. P. Casado;M. Cascella;C. Caso;A. M. Castaneda Hernandez;E. Castaneda-Miranda;V. Castillo Gimenez;N. F. Castro;G. Cataldi;F. Cataneo;A. Catinaccio;J. R. Catmore;A. Cattai;G. Cattani;S. Caughron;D. Cauz;P. Cavalleri;D. Cavalli;M. Cavalli-Sforza;V. Cavasinni;F. Ceradini;A. S. Cerqueira;A. Cerri;L. Cerrito;F. Cerutti;S. A. Cetin;F. Cevenini;A. Chafaq;D. Chakraborty;K. Chan;B. Chapleau;J. D. Chapman;J. W. Chapman;E. Chareyre;D. G. Charlton;V. Chavda;C. A. Chavez Barajas;S. Cheatham;S. Chekanov;S. V. Chekulaev;G. A. Chelkov;M. A. Chelstowska;C. Chen;H. Chen;S. Chen;T. Chen;X. Chen;S. Cheng;A. Cheplakov;V. F. Chepurnov;R. Cherkaoui El Moursli;V. Chernyatin;E. Cheu;S. L. Cheung;L. Chevalier;G. Chiefari;L. Chikovani;J. T. Childers;A. Chilingarov;G. Chiodini;M. V. Chizhov;G. Choudalakis;S. Chouridou;I. A. Christidi;A. Christov;D. Chromek-Burckhart;M. L. Chu;J. Chudoba;G. Ciapetti;K. Ciba;A. K. Ciftci;R. Ciftci;D. Cinca;V. Cindro;M. D. Ciobotaru;C. Ciocca;A. Ciocio;M. Cirilli;M. Citterio;M. Ciubancan;A. Clark;P. J. Clark;W. Cleland;J. C. Clemens;B. Clement;C. Clement;R. W. Clifft;Y. Coadou;M. Cobal;A. Coccaro;J. Cochran;P. Coe;J. G. Cogan;J. Coggeshall;E. Cogneras;C. D. Cojocaru;J. Colas;A. P. Colijn;N. J. Collins;C. Collins-Tooth;J. Collot;G. Colon;P. Conde Muiño;E. Coniavitis;M. C. Conidi;M. Consonni;V. Consorti;S. Constantinescu;C. Conta;F. Conventi;J. Cook;M. Cooke;B. D. Cooper;A. M. Cooper-Sarkar;K. Copic;T. Cornelissen;M. Corradi;F. Corriveau;A. Cortes-Gonzalez;G. Cortiana;G. Costa;M. J. Costa;D. Costanzo;T. Costin;D. CĂŽtĂ©;R. Coura Torres;L. Courneyea;G. Cowan;C. Cowden;B. E. Cox;K. Cranmer;F. Crescioli;M. Cristinziani;G. Crosetti;R. Crupi;S. CrĂ©pĂ©-Renaudin;C.-M. Cuciuc;C. Cuenca Almenar;T. Cuhadar Donszelmann;M. Curatolo;C. J. Curtis;C. Cuthbert;P. Cwetanski;H. Czirr;Z. Czyczula;S. D’Auria;M. D’Onofrio;A. D’Orazio;P. V. M. Silva;C. Via;W. Dabrowski;T. Dai;C. Dallapiccola;M. Dam;M. Dameri;D. S. Damiani;H. O. Danielsson;D. Dannheim;V. Dao;G. Darbo;G. L. Darlea;C. Daum;W. Davey;T. Davidek;N. Davidson;R. Davidson;E. Davies;M. Davies;A. R. Davison;Y. Davygora;E. Dawe;I. Dawson;J. W. Dawson;R. K. Daya-Ishmukhametova;K. De;R. Asmundis;S. Castro;P. E. Castro Faria Salgado;S. Cecco;J. Graat;N. Groot;P. Jong;C. Taille;H. Torre;B. Lotto;L. Mora;L. Nooij;D. Pedis;A. Salvo;U. Sanctis;A. Santo;J. B. Vivie De Regie;S. Dean;W. J. Dearnaley;R. Debbe;C. Debenedetti;D. V. Dedovich;J. Degenhardt;M. Dehchar;C. Papa;J. Peso;T. Prete;T. Delemontex;M. Deliyergiyev;A. Dell’Acqua;L. Dell’Asta;M. Pietra;D. Volpe;M. Delmastro;N. Delruelle;P. A. Delsart;C. Deluca;S. Demers;M. Demichev;B. Demirkoz;J. Deng;S. P. Denisov;D. Derendarz;J. E. Derkaoui;F. Derue;P. Dervan;K. Desch;E. Devetak;P. O. Deviveiros;A. Dewhurst;B. DeWilde;S. Dhaliwal;R. Dhullipudi;A. Ciaccio;L. Ciaccio;A. Girolamo;B. Girolamo;S. Luise;A. Mattia;B. Micco;R. Nardo;A. Simone;R. Sipio;M. A. Diaz;F. Diblen;E. B. Diehl;J. Dietrich;T. A. Dietzsch;S. Diglio;K. Dindar Yagci;J. Dingfelder;C. Dionisi;P. Dita;S. Dita;F. Dittus;F. Djama;T. Djobava;M. A. B. Vale;A. Valle Wemans;T. K. O. Doan;M. Dobbs;R. Dobinson;D. Dobos;E. Dobson;J. Dodd;C. Doglioni;T. Doherty;Y. Doi;J. Dolejsi;I. Dolenc;Z. Dolezal;B. A. Dolgoshein;T. Dohmae;M. Donadelli;M. Donega;J. Donini;J. Dopke;A. Doria;A. Anjos;M. Dosil;A. Dotti;M. T. Dova;J. D. Dowell;A. D. Doxiadis;A. T. Doyle;Z. Drasal;J. Drees;N. Dressnandt;H. Drevermann;C. Driouichi;M. Dris;J. Dubbert;S. Dube;E. Duchovni;G. Duckeck;A. Dudarev;F. Dudziak;M. DĂŒhrssen;I. P. Duerdoth;L. Duflot;M-A. Dufour;M. Dunford;H. Duran Yildiz;R. Duxfield;M. Dwuznik;F. Dydak;M. DĂŒren;W. L. Ebenstein;J. Ebke;S. Eckweiler;K. Edmonds;C. A. Edwards;N. C. Edwards;W. Ehrenfeld;T. Ehrich;T. Eifert;G. Eigen;K. Einsweiler;E. Eisenhandler;T. Ekelof;M. Kacimi;M. Ellert;S. Elles;F. Ellinghaus;K. Ellis;N. Ellis;J. Elmsheuser;M. Elsing;D. Emeliyanov;R. Engelmann;A. Engl;B. Epp;A. Eppig;J. Erdmann;A. Ereditato;D. Eriksson;J. Ernst;M. Ernst;J. Ernwein;D. Errede;S. Errede;E. Ertel;M. Escalier;C. Escobar;X. Espinal Curull;B. Esposito;F. Etienne;A. I. Etienvre;E. Etzion;D. Evangelakou;H. Evans;L. Fabbri;C. Fabre;R. M. Fakhrutdinov;S. Falciano;Y. Fang;M. Fanti;A. Farbin;A. Farilla;J. Farley;T. Farooque;S. M. Farrington;P. Farthouat;P. Fassnacht;D. Fassouliotis;B. Fatholahzadeh;A. Favareto;L. Fayard;S. Fazio;R. Febbraro;P. Federic;O. L. Fedin;W. Fedorko;M. Fehling-Kaschek;L. Feligioni;D. Fellmann;C. Feng;E. J. Feng;A. B. Fenyuk;J. Ferencei;J. Ferland;W. Fernando;S. Ferrag;J. Ferrando;V. Ferrara;A. Ferrari;P. Ferrari;R. Ferrari;A. Ferrer;M. L. Ferrer;D. Ferrere;C. Ferretti;A. Ferretto Parodi;M. Fiascaris;F. Fiedler;A. Filipčič;A. Filippas;F. Filthaut;M. Fincke-Keeler;M. C. N. Fiolhais;L. Fiorini;A. Firan;G. Fischer;P. Fischer;M. J. Fisher;M. Flechl;I. Fleck;J. Fleckner;P. Fleischmann;S. Fleischmann;T. Flick;L. R. Flores Castillo;M. J. Flowerdew;M. Fokitis;T. Fonseca Martin;J. Fopma;D. A. Forbush;A. Formica;A. Forti;D. Fortin;J. M. Foster;D. Fournier;A. Foussat;A. J. Fowler;K. Fowler;H. Fox;P. Francavilla;S. Franchino;D. Francis;T. Frank;M. Franklin;S. Franz;M. Fraternali;S. Fratina;S. T. French;F. Friedrich;R. Froeschl;D. Froidevaux;J. A. Frost;C. Fukunaga;E. Fullana Torregrosa;J. Fuster;C. Gabaldon;O. Gabizon;T. Gadfort;S. Gadomski;G. Gagliardi;P. Gagnon;C. Galea;E. J. Gallas;V. Gallo;B. J. Gallop;P. Gallus;K. K. Gan;Y. S. Gao;V. A. Gapienko;A. Gaponenko;F. Garberson;M. Garcia-Sciveres;C. GarcĂ­a;J. E. GarcĂ­a Navarro;R. W. Gardner;N. Garelli;H. Garitaonandia;V. Garonne;J. Garvey;C. Gatti;G. Gaudio;O. Gaumer;B. Gaur;L. Gauthier;I. L. Gavrilenko;C. Gay;G. Gaycken;J-C. Gayde;E. N. Gazis;P. Ge;C. N. P. Gee;D. A. A. Geerts;Ch. Geich-Gimbel;K. Gellerstedt;C. Gemme;A. Gemmell;M. H. Genest;S. Gentile;M. George;S. George;P. Gerlach;A. Gershon;C. Geweniger;H. Ghazlane;N. Ghodbane;B. Giacobbe;S. Giagu;V. Giakoumopoulou;V. Giangiobbe;F. Gianotti;B. Gibbard;A. Gibson;S. M. Gibson;L. M. Gilbert;V. Gilewsky;D. Gillberg;A. R. Gillman;D. M. Gingrich;J. Ginzburg;N. Giokaris;M. P. Giordani;R. Giordano;F. M. Giorgi;P. Giovannini;P. F. Giraud;D. Giugni;M. Giunta;P. Giusti;B. K. Gjelsten;L. K. Gladilin;C. Glasman;J. Glatzer;A. Glazov;K. W. Glitza;G. L. Glonti;J. Godfrey;J. Godlewski;M. Goebel;T. Göpfert;C. Goeringer;C. Gössling;T. Göttfert;S. Goldfarb;T. Golling;S. N. Golovnia;A. Gomes;L. S. Gomez Fajardo;R. Gonçalo;J. Goncalves Pinto Firmino Da Costa;L. Gonella;A. Gonidec;S. Gonzalez;S. GonzĂĄlez de la Hoz;G. Gonzalez Parra;M. L. Gonzalez Silva;S. Gonzalez-Sevilla;J. J. Goodson;L. Goossens;P. A. Gorbounov;H. A. Gordon;I. Gorelov;G. Gorfine;B. Gorini;E. Gorini;A. GoriĆĄek;E. Gornicki;S. A. Gorokhov;V. N. Goryachev;B. Gosdzik;M. Gosselink;M. I. Gostkin;I. Gough Eschrich;M. Gouighri;D. Goujdami;M. P. Goulette;A. G. Goussiou;C. Goy;S. Gozpinar;I. Grabowska-Bold;P. Grafström;K-J. Grahn;F. Grancagnolo;S. Grancagnolo;V. Grassi;V. Gratchev;N. Grau;H. M. Gray;J. A. Gray;E. Graziani;O. G. Grebenyuk;T. Greenshaw;Z. D. Greenwood;K. Gregersen;I. M. Gregor;P. Grenier;J. Griffiths;N. Grigalashvili;A. A. Grillo;S. Grinstein;Y. V. Grishkevich;J.-F. Grivaz;M. Groh;E. Gross;J. Grosse-Knetter;J. Groth-Jensen;K. Grybel;V. J. Guarino;D. Guest;C. Guicheney;A. Guida;S. Guindon;H. Guler;J. Gunther;B. Guo;J. Guo;A. Gupta;Y. Gusakov;V. N. Gushchin;A. Gutierrez;P. Gutierrez;N. Guttman;O. Gutzwiller;C. Guyot;C. Gwenlan;C. B. Gwilliam;A. Haas;S. Haas;C. Haber;H. K. Hadavand;D. R. Hadley;P. Haefner;F. Hahn;S. Haider;Z. Hajduk;H. Hakobyan;D. Hall;J. Haller;K. Hamacher;P. Hamal;M. Hamer;A. Hamilton;S. Hamilton;H. Han;L. Han;K. Hanagaki;K. Hanawa;M. Hance;C. Handel;P. Hanke;J. R. Hansen;J. B. Hansen;J. D. Hansen;P. H. Hansen;P. Hansson;K. Hara;G. A. Hare;T. Harenberg;S. Harkusha;D. Harper;R. D. Harrington;O. M. Harris;K. Harrison;J. Hartert;F. Hartjes;T. Haruyama;A. Harvey;S. Hasegawa;Y. Hasegawa;S. Hassani;M. Hatch;D. Hauff;S. Haug;M. Hauschild;R. Hauser;M. Havranek;B. M. Hawes;C. M. Hawkes;R. J. Hawkings;D. Hawkins;T. Hayakawa;T. Hayashi;D. Hayden;H. S. Hayward;S. J. Haywood;E. Hazen;M. He;S. J. Head;V. Hedberg;L. Heelan;S. Heim;B. Heinemann;S. Heisterkamp;L. Helary;C. Heller;M. Heller;S. Hellman;D. Hellmich;C. Helsens;R. C. W. Henderson;M. Henke;A. Henrichs;A. M. Henriques Correia;S. Henrot-Versille;F. Henry-Couannier;C. Hensel;T. Henß;C. M. Hernandez;Y. HernĂĄndez JimĂ©nez;R. Herrberg;A. D. Hershenhorn;G. Herten;R. Hertenberger;L. Hervas;N. P. Hessey;E. HigĂłn-Rodriguez;D. Hill;J. C. Hill;N. Hill;K. H. Hiller;S. Hillert;S. J. Hillier;I. Hinchliffe;E. Hines;M. Hirose;F. Hirsch;D. Hirschbuehl;J. Hobbs;N. Hod;M. C. Hodgkinson;P. Hodgson;A. Hoecker;M. R. Hoeferkamp;J. Hoffman;D. Hoffmann;M. Hohlfeld;M. Holder;S. O. Holmgren;T. Holy;J. L. Holzbauer;Y. Homma;T. M. Hong;L. Hooft van Huysduynen;T. Horazdovsky;C. Horn;S. Horner;J-Y. Hostachy;S. Hou;M. A. Houlden;A. Hoummada;J. Howarth;D. F. Howell;I. Hristova;J. Hrivnac;I. Hruska;T. Hryn’ova;P. J. Hsu;S.-C. Hsu;G. S. Huang;Z. Hubacek;F. Hubaut;F. Huegging;T. B. Huffman;E. W. Hughes;G. Hughes;R. E. Hughes-Jones;M. Huhtinen;P. Hurst;M. Hurwitz;U. Husemann;N. Huseynov;J. Huston;J. Huth;G. Iacobucci;G. Iakovidis;M. Ibbotson;I. Ibragimov;R. Ichimiya;L. Iconomidou-Fayard;J. Idarraga;P. Iengo;O. Igonkina;Y. Ikegami;M. Ikeno;Y. Ilchenko;D. Iliadis;N. Ilic;D. Imbault;M. Imori;T. Ince;J. Inigo-Golfin;P. Ioannou;M. Iodice;A. Irles Quiles;C. Isaksson;A. Ishikawa;M. Ishino;R. Ishmukhametov;C. Issever;S. Istin;A. V. Ivashin;W. Iwanski;H. Iwasaki;J. M. Izen;V. Izzo;B. Jackson;J. N. Jackson;P. Jackson;M. R. Jaekel;V. Jain;K. Jakobs;S. Jakobsen;J. Jakubek;D. K. Jana;E. Jankowski;E. Jansen;H. Jansen;A. Jantsch;M. Janus;G. Jarlskog;L. Jeanty;K. Jelen;I. Jen-La Plante;P. Jenni;A. Jeremie;P. JeĆŸ;S. JĂ©zĂ©quel;M. K. Jha;H. Ji;W. Ji;J. Jia;Y. Jiang;M. Jimenez Belenguer;G. Jin;S. Jin;O. Jinnouchi;M. D. Joergensen;D. Joffe;L. G. Johansen;M. Johansen;K. E. Johansson;P. Johansson;S. Johnert;K. A. Johns;K. Jon-And;G. Jones;R. W. L. Jones;T. W. Jones;T. J. Jones;O. Jonsson;C. Joram;P. M. Jorge;J. Joseph;T. Jovin;X. Ju;C. A. Jung;V. Juranek;P. Jussel;A. Juste Rozas;V. V. Kabachenko;S. Kabana;M. Kaci;A. Kaczmarska;P. Kadlecik;M. Kado;H. Kagan;M. Kagan;S. Kaiser;E. Kajomovitz;S. Kalinin;L. V. Kalinovskaya;S. Kama;N. Kanaya;M. Kaneda;T. Kanno;V. A. Kantserov;J. Kanzaki;B. Kaplan;A. Kapliy;J. Kaplon;D. Kar;M. Karagounis;M. Karagoz;M. Karnevskiy;K. Karr;V. Kartvelishvili;A. N. Karyukhin;L. Kashif;G. Kasieczka;R. D. Kass;A. Kastanas;M. Kataoka;Y. Kataoka;E. Katsoufis;J. Katzy;V. Kaushik;K. Kawagoe;T. Kawamoto;G. Kawamura;M. S. Kayl;V. A. Kazanin;M. Y. Kazarinov;J. R. Keates;R. Keeler;R. Kehoe;M. Keil;G. D. Kekelidze;J. Kennedy;C. J. Kenney;M. Kenyon;O. Kepka;N. Kerschen;B. P. KerĆĄevan;S. Kersten;K. Kessoku;J. Keung;F. Khalil-zada;H. Khandanyan;A. Khanov;D. Kharchenko;A. Khodinov;A. G. Kholodenko;A. Khomich;T. J. Khoo;G. Khoriauli;A. Khoroshilov;N. Khovanskiy;V. Khovanskiy;E. Khramov;J. Khubua;H. Kim;M. S. Kim;P. C. Kim;S. H. Kim;N. Kimura;O. Kind;B. T. King;M. King;R. S. B. King;J. 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Kowalski;W. Kozanecki;A. S. Kozhin;V. Kral;V. A. Kramarenko;G. Kramberger;M. W. Krasny;A. Krasznahorkay;J. Kraus;J. K. Kraus;A. Kreisel;F. Krejci;J. Kretzschmar;N. Krieger;P. Krieger;K. Kroeninger;H. Kroha;J. Kroll;J. Kroseberg;J. Krstic;U. Kruchonak;H. KrĂŒger;T. Kruker;N. Krumnack;Z. V. Krumshteyn;A. Kruth;T. Kubota;S. Kuehn;A. Kugel;T. Kuhl;D. Kuhn;V. Kukhtin;Y. Kulchitsky;S. Kuleshov;C. Kummer;M. Kuna;N. Kundu;J. Kunkle;A. Kupco;H. Kurashige;M. Kurata;Y. A. Kurochkin;V. Kus;M. Kuze;J. Kvita;R. Kwee;A. Rosa;L. Rotonda;L. Labarga;J. Labbe;S. Lablak;C. Lacasta;F. Lacava;H. Lacker;D. Lacour;V. R. Lacuesta;E. Ladygin;R. Lafaye;B. Laforge;T. Lagouri;S. Lai;E. Laisne;M. Lamanna;C. L. Lampen;W. Lampl;E. Lancon;U. Landgraf;M. P. J. Landon;H. Landsman;J. L. Lane;C. Lange;A. J. Lankford;F. Lanni;K. Lantzsch;S. Laplace;C. Lapoire;J. F. Laporte;T. Lari;A. V. Larionov;A. Larner;C. Lasseur;M. Lassnig;P. Laurelli;W. Lavrijsen;P. Laycock;A. B. Lazarev;O. Dortz;E. Guirriec;C. Maner;E. Menedeu;C. Lebel;T. LeCompte;F. Ledroit-Guillon;H. Lee;J. S. H. Lee;S. C. Lee;L. Lee;M. Lefebvre;M. Legendre;A. Leger;B. C. LeGeyt;F. Legger;C. Leggett;M. Lehmacher;G. Lehmann Miotto;X. Lei;M. A. L. Leite;R. Leitner;D. Lellouch;M. Leltchouk;B. Lemmer;V. Lendermann;K. J. C. Leney;T. Lenz;G. Lenzen;B. Lenzi;K. Leonhardt;S. Leontsinis;C. Leroy;J-R. Lessard;J. Lesser;C. G. Lester;A. Leung Fook Cheong;J. LevĂȘque;D. Levin;L. J. Levinson;M. S. Levitski;A. Lewis;G. H. Lewis;A. M. Leyko;M. Leyton;B. Li;H. Li;S. Li;X. Li;Z. Liang;H. Liao;B. Liberti;P. Lichard;M. Lichtnecker;K. Lie;W. Liebig;R. Lifshitz;C. Limbach;A. Limosani;M. Limper;S. C. Lin;F. Linde;J. T. Linnemann;E. Lipeles;L. Lipinsky;A. Lipniacka;T. M. Liss;D. Lissauer;A. Lister;A. M. Litke;C. Liu;D. Liu;H. Liu;J. B. Liu;M. Liu;S. Liu;Y. Liu;M. Livan;S. S. A. Livermore;A. Lleres;J. Llorente Merino;S. L. Lloyd;E. Lobodzinska;P. Loch;W. S. Lockman;T. Loddenkoetter;F. K. Loebinger;A. Loginov;C. W. Loh;T. Lohse;K. Lohwasser;M. Lokajicek;J. Loken;V. P. Lombardo;R. E. Long;L. Lopes;D. Lopez Mateos;J. Lorenz;M. Losada;P. Loscutoff;F. Lo Sterzo;M. J. Losty;X. Lou;A. Lounis;K. F. Loureiro;J. Love;P. A. Love;A. J. Lowe;F. Lu;H. J. Lubatti;C. Luci;A. Lucotte;A. Ludwig;D. Ludwig;I. Ludwig;J. Ludwig;F. Luehring;G. Luijckx;D. Lumb;L. Luminari;E. Lund;B. Lund-Jensen;B. Lundberg;J. Lundberg;J. Lundquist;M. Lungwitz;G. Lutz;D. Lynn;J. Lys;E. Lytken;H. Ma;L. L. Ma;J. A. Macana Goia;G. Maccarrone;A. Macchiolo;B. Maček;J. Machado Miguens;R. Mackeprang;R. J. Madaras;W. F. Mader;R. Maenner;T. Maeno;P. MĂ€ttig;S. MĂ€ttig;L. Magnoni;E. Magradze;Y. Mahalalel;K. Mahboubi;G. Mahout;C. Maiani;C. Maidantchik;A. Maio;S. Majewski;Y. Makida;N. Makovec;P. Mal;Pa. Malecki;P. Malecki;V. P. Maleev;F. Malek;U. Mallik;D. Malon;C. Malone;S. Maltezos;V. Malyshev;S. Malyukov;R. Mameghani;J. Mamuzic;A. Manabe;L. Mandelli;I. Mandić;R. Mandrysch;J. Maneira;P. S. Mangeard;I. D. Manjavidze;A. Mann;P. M. Manning;A. Manousakis-Katsikakis;B. Mansoulie;A. Manz;A. Mapelli;L. Mapelli;L. March;J. F. Marchand;F. Marchese;G. Marchiori;M. Marcisovsky;A. Marin;C. P. Marino;F. Marroquim;R. Marshall;Z. Marshall;F. K. Martens;S. Marti-Garcia;A. J. Martin;B. Martin;B. Martin;F. F. Martin;J. P. Martin;Ph. Martin;T. A. Martin;V. J. Martin;B. Ma

    A multimodal cell census and atlas of the mammalian primary motor cortex

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    none258Here we report the generation of a multimodal cell census and atlas of the mammalian primary motor cortex as the initial product of the BRAIN Initiative Cell Census Network (BICCN). This was achieved by coordinated large-scale analyses of single-cell transcriptomes, chromatin accessibility, DNA methylomes, spatially resolved single-cell transcriptomes, morphological and electrophysiological properties and cellular resolution input-output mapping, integrated through cross-modal computational analysis. Our results advance the collective knowledge and understanding of brain cell-type organization1-5. First, our study reveals a unified molecular genetic landscape of cortical cell types that integrates their transcriptome, open chromatin and DNA methylation maps. Second, cross-species analysis achieves a consensus taxonomy of transcriptomic types and their hierarchical organization that is conserved from mouse to marmoset and human. Third, in situ single-cell transcriptomics provides a spatially resolved cell-type atlas of the motor cortex. Fourth, cross-modal analysis provides compelling evidence for the transcriptomic, epigenomic and gene regulatory basis of neuronal phenotypes such as their physiological and anatomical properties, demonstrating the biological validity and genomic underpinning of neuron types. We further present an extensive genetic toolset for targeting glutamatergic neuron types towards linking their molecular and developmental identity to their circuit function. Together, our results establish a unifying and mechanistic framework of neuronal cell-type organization that integrates multi-layered molecular genetic and spatial information with multi-faceted phenotypic properties.openCallaway, Edward M.; Dong, Hong-Wei; Ecker, Joseph R.; Hawrylycz, Michael J.; Huang, Z. Josh; Lein, Ed S.; Ngai, John; Osten, Pavel; Ren, Bing; Tolias, Andreas Savas; White, Owen; Zeng, Hongkui; Zhuang, Xiaowei; Ascoli, Giorgio A.; Behrens, M. Margarita; Chun, Jerold; Feng, Guoping; Gee, James C.; Ghosh, Satrajit S.; Halchenko, Yaroslav O.; Hertzano, Ronna; Lim, Byung Kook; Martone, Maryann E.; Ng, Lydia; Pachter, Lior; Ropelewski, Alexander J.; Tickle, Timothy L.; Yang, X. William; Zhang, Kun; Bakken, Trygve E.; Berens, Philipp; Daigle, Tanya L.; Harris, Julie A.; Jorstad, Nikolas L.; Kalmbach, Brian E.; Kobak, Dmitry; Li, Yang Eric; Liu, Hanqing; Matho, Katherine S.; Mukamel, Eran A.; Naeemi, Maitham; Scala, Federico; Tan, Pengcheng; Ting, Jonathan T.; Xie, Fangming; Zhang, Meng; Zhang, Zhuzhu; Zhou, Jingtian; Zingg, Brian; Armand, Ethan; Yao, Zizhen; Bertagnolli, Darren; Casper, Tamara; Crichton, Kirsten; Dee, Nick; Diep, Dinh; Ding, Song-Lin; Dong, Weixiu; Dougherty, Elizabeth L.; Fong, Olivia; Goldman, Melissa; Goldy, Jeff; Hodge, Rebecca D.; Hu, Lijuan; Keene, C. Dirk; Krienen, Fenna M.; Kroll, Matthew; Lake, Blue B.; Lathia, Kanan; Linnarsson, Sten; Liu, Christine S.; Macosko, Evan Z.; McCarroll, Steven A.; McMillen, Delissa; Nadaf, Naeem M.; Nguyen, Thuc Nghi; Palmer, Carter R.; Pham, Thanh; Plongthongkum, Nongluk; Reed, Nora M.; Regev, Aviv; Rimorin, Christine; Romanow, William J.; Savoia, Steven; Siletti, Kimberly; Smith, Kimberly; Sulc, Josef; Tasic, Bosiljka; Tieu, Michael; Torkelson, Amy; Tung, Herman; van Velthoven, Cindy T. J.; Vanderburg, Charles R.; Yanny, Anna Marie; Fang, Rongxin; Hou, Xiaomeng; Lucero, Jacinta D.; Osteen, Julia K.; Pinto-Duarte, Antonio; Poirion, Olivier; Preissl, Sebastian; Wang, Xinxin; Aldridge, Andrew I.; Bartlett, Anna; Boggeman, Lara; O’Connor, Carolyn; Castanon, Rosa G.; Chen, Huaming; Fitzpatrick, Conor; Luo, Chongyuan; Nery, Joseph R.; Nunn, Michael; Rivkin, Angeline C.; Tian, Wei; Dominguez, Bertha; Ito-Cole, Tony; Jacobs, Matthew; Jin, Xin; Lee, Cheng-Ta; Lee, Kuo-Fen; Miyazaki, Paula Assakura; Pang, Yan; Rashid, Mohammad; Smith, Jared B.; Vu, Minh; Williams, Elora; Biancalani, Tommaso; Booeshaghi, A. Sina; Crow, Megan; Dudoit, Sandrine; Fischer, Stephan; Gillis, Jesse; Hu, Qiwen; Kharchenko, Peter V.; Niu, Sheng-Yong; Ntranos, Vasilis; Purdom, Elizabeth; Risso, Davide; de BĂ©zieux, Hector Roux; Somasundaram, Saroja; Street, Kelly; Svensson, Valentine; Vaishnav, Eeshit Dhaval; Van den Berge, Koen; Welch, Joshua D.; An, Xu; Bateup, Helen S.; Bowman, Ian; Chance, Rebecca K.; Foster, Nicholas N.; Galbavy, William; Gong, Hui; Gou, Lin; Hatfield, Joshua T.; Hintiryan, Houri; Hirokawa, Karla E.; Kim, Gukhan; Kramer, Daniel J.; Li, Anan; Li, Xiangning; Luo, Qingming; Muñoz-Castañeda, Rodrigo; Stafford, David A.; Feng, Zhao; Jia, Xueyan; Jiang, Shengdian; Jiang, Tao; Kuang, Xiuli; Larsen, Rachael; Lesnar, Phil; Li, Yaoyao; Li, Yuanyuan; Liu, Lijuan; Peng, Hanchuan; Qu, Lei; Ren, Miao; Ruan, Zongcai; Shen, Elise; Song, Yuanyuan; Wakeman, Wayne; Wang, Peng; Wang, Yimin; Wang, Yun; Yin, Lulu; Yuan, Jing; Zhao, Sujun; Zhao, Xuan; Narasimhan, Arun; Palaniswamy, Ramesh; Banerjee, Samik; Ding, Liya; Huilgol, Dhananjay; Huo, Bingxing; Kuo, Hsien-Chi; Laturnus, Sophie; Li, Xu; Mitra, Partha P.; Mizrachi, Judith; Wang, Quanxin; Xie, Peng; Xiong, Feng; Yu, Yang; Eichhorn, Stephen W.; Berg, Jim; Bernabucci, Matteo; Bernaerts, Yves; Cadwell, Cathryn RenĂ©; Castro, Jesus Ramon; Dalley, Rachel; Hartmanis, Leonard; Horwitz, Gregory D.; Jiang, Xiaolong; Ko, Andrew L.; Miranda, Elanine; Mulherkar, Shalaka; Nicovich, Philip R.; Owen, Scott F.; Sandberg, Rickard; Sorensen, Staci A.; Tan, Zheng Huan; Allen, Shona; Hockemeyer, Dirk; Lee, Angus Y.; Veldman, Matthew B.; Adkins, Ricky S.; Ament, Seth A.; Bravo, HĂ©ctor Corrada; Carter, Robert; Chatterjee, Apaala; Colantuoni, Carlo; Crabtree, Jonathan; Creasy, Heather; Felix, Victor; Giglio, Michelle; Herb, Brian R.; Kancherla, Jayaram; Mahurkar, Anup; McCracken, Carrie; Nickel, Lance; Olley, Dustin; Orvis, Joshua; Schor, Michael; Hood, Greg; Dichter, Benjamin; Grauer, Michael; Helba, Brian; Bandrowski, Anita; Barkas, Nikolaos; Carlin, Benjamin; D’Orazi, Florence D.; Degatano, Kylee; Gillespie, Thomas H.; Khajouei, Farzaneh; Konwar, Kishori; Thompson, Carol; Kelly, Kathleen; Mok, Stephanie; Sunkin, SusanCallaway, Edward M.; Dong, Hong-Wei; Ecker, Joseph R.; Hawrylycz, Michael J.; Huang, Z. Josh; Lein, Ed S.; Ngai, John; Osten, Pavel; Ren, Bing; Tolias, Andreas Savas; White, Owen; Zeng, Hongkui; Zhuang, Xiaowei; Ascoli, Giorgio A.; Behrens, M. Margarita; Chun, Jerold; Feng, Guoping; Gee, James C.; Ghosh, Satrajit S.; Halchenko, Yaroslav O.; Hertzano, Ronna; Lim, Byung Kook; Martone, Maryann E.; Ng, Lydia; Pachter, Lior; Ropelewski, Alexander J.; Tickle, Timothy L.; Yang, X. William; Zhang, Kun; Bakken, Trygve E.; Berens, Philipp; Daigle, Tanya L.; Harris, Julie A.; Jorstad, Nikolas L.; Kalmbach, Brian E.; Kobak, Dmitry; Li, Yang Eric; Liu, Hanqing; Matho, Katherine S.; Mukamel, Eran A.; Naeemi, Maitham; Scala, Federico; Tan, Pengcheng; Ting, Jonathan T.; Xie, Fangming; Zhang, Meng; Zhang, Zhuzhu; Zhou, Jingtian; Zingg, Brian; Armand, Ethan; Yao, Zizhen; Bertagnolli, Darren; Casper, Tamara; Crichton, Kirsten; Dee, Nick; Diep, Dinh; Ding, Song-Lin; Dong, Weixiu; Dougherty, Elizabeth L.; Fong, Olivia; Goldman, Melissa; Goldy, Jeff; Hodge, Rebecca D.; Hu, Lijuan; Keene, C. Dirk; Krienen, Fenna M.; Kroll, Matthew; Lake, Blue B.; Lathia, Kanan; Linnarsson, Sten; Liu, Christine S.; Macosko, Evan Z.; Mccarroll, Steven A.; Mcmillen, Delissa; Nadaf, Naeem M.; Nguyen, Thuc Nghi; Palmer, Carter R.; Pham, Thanh; Plongthongkum, Nongluk; Reed, Nora M.; Regev, Aviv; Rimorin, Christine; Romanow, William J.; Savoia, Steven; Siletti, Kimberly; Smith, Kimberly; Sulc, Josef; Tasic, Bosiljka; Tieu, Michael; Torkelson, Amy; Tung, Herman; van Velthoven, Cindy T. J.; Vanderburg, Charles R.; Yanny, Anna Marie; Fang, Rongxin; Hou, Xiaomeng; Lucero, Jacinta D.; Osteen, Julia K.; Pinto-Duarte, Antonio; Poirion, Olivier; Preissl, Sebastian; Wang, Xinxin; Aldridge, Andrew I.; Bartlett, Anna; Boggeman, Lara; O’Connor, Carolyn; Castanon, Rosa G.; Chen, Huaming; Fitzpatrick, Conor; Luo, Chongyuan; Nery, Joseph R.; Nunn, Michael; Rivkin, Angeline C.; Tian, Wei; Dominguez, Bertha; Ito-Cole, Tony; Jacobs, Matthew; Jin, Xin; Lee, Cheng-Ta; Lee, Kuo-Fen; Miyazaki, Paula Assakura; Pang, Yan; Rashid, Mohammad; Smith, Jared B.; Vu, Minh; Williams, Elora; Biancalani, Tommaso; Booeshaghi, A. Sina; Crow, Megan; Dudoit, Sandrine; Fischer, Stephan; Gillis, Jesse; Hu, Qiwen; Kharchenko, Peter V.; Niu, Sheng-Yong; Ntranos, Vasilis; Purdom, Elizabeth; Risso, Davide; de BĂ©zieux, Hector Roux; Somasundaram, Saroja; Street, Kelly; Svensson, Valentine; Vaishnav, Eeshit Dhaval; Van den Berge, Koen; Welch, Joshua D.; An, Xu; Bateup, Helen S.; Bowman, Ian; Chance, Rebecca K.; Foster, Nicholas N.; Galbavy, William; Gong, Hui; Gou, Lin; Hatfield, Joshua T.; Hintiryan, Houri; Hirokawa, Karla E.; Kim, Gukhan; Kramer, Daniel J.; Li, Anan; Li, Xiangning; Luo, Qingming; Muñoz-Castañeda, Rodrigo; Stafford, David A.; Feng, Zhao; Jia, Xueyan; Jiang, Shengdian; Jiang, Tao; Kuang, Xiuli; Larsen, Rachael; Lesnar, Phil; Li, Yaoyao; Li, Yuanyuan; Liu, Lijuan; Peng, Hanchuan; Qu, Lei; Ren, Miao; Ruan, Zongcai; Shen, Elise; Song, Yuanyuan; Wakeman, Wayne; Wang, Peng; Wang, Yimin; Wang, Yun; Yin, Lulu; Yuan, Jing; Zhao, Sujun; Zhao, Xuan; Narasimhan, Arun; Palaniswamy, Ramesh; Banerjee, Samik; Ding, Liya; Huilgol, Dhananjay; Huo, Bingxing; Kuo, Hsien-Chi; Laturnus, Sophie; Li, Xu; Mitra, Partha P.; Mizrachi, Judith; Wang, Quanxin; Xie, Peng; Xiong, Feng; Yu, Yang; Eichhorn, Stephen W.; Berg, Jim; Bernabucci, Matteo; Bernaerts, Yves; Cadwell, Cathryn RenĂ©; Castro, Jesus Ramon; Dalley, Rachel; Hartmanis, Leonard; Horwitz, Gregory D.; Jiang, Xiaolong; Ko, Andrew L.; Miranda, Elanine; Mulherkar, Shalaka; Nicovich, Philip R.; Owen, Scott F.; Sandberg, Rickard; Sorensen, Staci A.; Tan, Zheng Huan; Allen, Shona; Hockemeyer, Dirk; Lee, Angus Y.; Veldman, Matthew B.; Adkins, Ricky S.; Ament, Seth A.; Bravo, HĂ©ctor Corrada; Carter, Robert; Chatterjee, Apaala; Colantuoni, Carlo; Crabtree, Jonathan; Creasy, Heather; Felix, Victor; Giglio, Michelle; Herb, Brian R.; Kancherla, Jayaram; Mahurkar, Anup; Mccracken, Carrie; Nickel, Lance; Olley, Dustin; Orvis, Joshua; Schor, Michael; Hood, Greg; Dichter, Benjamin; Grauer, Michael; Helba, Brian; Bandrowski, Anita; Barkas, Nikolaos; Carlin, Benjamin; D’Orazi, Florence D.; Degatano, Kylee; Gillespie, Thomas H.; Khajouei, Farzaneh; Konwar, Kishori; Thompson, Carol; Kelly, Kathleen; Mok, Stephanie; Sunkin, Susa
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