Imagining the Past - Remembering the Future

At its most general level the author\u27s critique is captured in the title of this Comment. In his view, Edley and Sunstein imagine the past of administrative law that represents but a partial understanding of where we have been and where we have come. They then propose a future that is, he fears, made up primarily of the recollection and extension of reforms that have already been attempted. Thus, their arguments have modest capacities, if applied generally, to do more good than harm

Small Things like Reasons are Put in a Jar: Reason and Legitimacy in the Administrative State

Why is a multi-purpose word. It is the language of curiosity, evidence of intellectual engagement. We revel in our children\u27s and our students\u27 whys; reward their curiosity with attention and serious responses; turn their whys back on them- why do you think? -to stimulate independent thought, reflection. Why is also a language of attention getting, even harassment. One of my favorite cartoons-I think it\u27s from The New Yorker, perhaps by Ogden Nash-shows a small child leaning forward from the back seat close to his driving father\u27s ear. The conversation must have been the familiar one with a bored four-year old on a car trip: Why aren\u27t we there yet? Why are you going so slow? Why does Grandma live so far away? and so on, and on. The caption at the bottom gives the harassed father\u27s response: Shut up, he explained

Law and Engineering: In Search of the Law-Science Problem

Lawyers and scientists both have the intellectual conceit that a well-defined problem is not only a necessary, but almost a sufficient, condition for a successful solution. Mashaw examines the applied science of engineering in the context of health and safety regulation, focusing on the law-science interface at the NHTSA

Civil Liability of Government Officers: Property Rights and Official Accountability

The law under which government officials operate permits them to inflict injury on others, under prescribed circumstances, in established ways, and in carefully (and sometimes not so carefully) calibrated amounts. Indeed, the law goes further: it sometimes tells the official that a failure to injure-that is, to coerce compliance with a predetermined rule of conduct-is a dereliction of official duty. For although there may be interminable argument over the social goals that justify the state in using force, all but the most extreme libertarians concede some place to governmental, and therefore official, coercion. The legal system\u27s permitting-or requiring-officially inflicted harms need not, however, be viewed as meaning that official harms have a peculiar legal position. At its most general level the law governing civil liability imposes an obligation to repair any negligent or intentional harm inflicted upon another.1 This liability rule obtains unless the harmful action can be justified by appeal to special circumstances.\u27 When harmful action is authorized by the statutes, regulations, customs, and interpretations empowering and instructing officials, such authorization may be viewed as merely one form of justification. Neither the constable who enters blackacre pursuant to a valid warrant nor the buyer who enters pursuant to a contract of sale will be held liable for trespass

Law and Engineering: In Search of the Law-Science Problem

Lawyers and scientists both have the intellectual conceit that a well-defined problem is not only a necessary, but almost a sufficient, condition for a successful solution. Mashaw examines the applied science of engineering in the context of health and safety regulation, focusing on the law-science interface at the NHTSA

A Practical Information Technology Program

This paper discusses the challenges facing business in the 21 st century and the dramatic changes in the use of computers and application development process. These challenges, as well as the increase of global economy, coupled with the demand for the business technology workers indicate the need for redesigning the Information System Curriculum. The proposed framework for an Information Technology (IT) Program in this paper offers a pragmatic curriculum model to accommodate the needs and challenges of the 21st century. The framework provides a fundamental IT education for the graduates of such a curriculum, as well as allowing an area of specialization. In addition, the program can be implemented easily with existing resources

The Role of Notch3 in Human Adipose Stem Cell Fate

Stem cell-based therapies are the future of medicine, as their natural abilities of self-renewal and differentiation have the potential to treat currently incurable diseases. Stem cells are categorized based on differentiation potential, with multipotent stem cells being the most differentiated while still having the ability to divide down defined lineages. Adipose stem cells (hASCs) are easily derived multipotent, mesenchymal stem cells with already demonstrated therapeutic potential. Despite current success, there are a multitude of factors that regulate the physiology and role of adipose stem cells, including transduction pathways and transcription factors, that remain to be researched and fully understood. One such transduction pathway –the Notch signaling pathway– is known to be crucial in stem cell proliferation, differentiation, and apoptosis in all animals. The focus of my research is on Notch3, one of four Notch transmembrane surface receptors involved in stem cell fate determination, embryonic development, and some forms of cancer. I utilized siRNA-mediated knockdowns of Notch3 to evaluate its role in stem cell proliferation, self-renewal, metabolism, and morphology. Results have indicated that Notch3 plays a highly active role in cellular proliferation and self-renewal, while not eliciting an effect on metabolism and morphology. This data continues to drive the research into stem cells and their regulators forward, bringing us one step closer to finding curative degenerative disease treatments