A computer model of auditory efferent suppression: Implications for the recognition of speech in noise

The neural mechanisms underlying the ability of human listeners to recognize speech in the presence of background noise are still imperfectly understood. However, there is mounting evidence that the medial olivocochlear system plays an important role, via efferents that exert a suppressive effect on the response of the basilar membrane. The current paper presents a computer modeling study that investigates the possible role of this activity on speech intelligibility in noise. A model of auditory efferent processing [ Ferry, R. T., and Meddis, R. (2007). J. Acoust. Soc. Am. 122, 3519?3526 ] is used to provide acoustic features for a statistical automatic speech recognition system, thus allowing the effects of efferent activity on speech intelligibility to be quantified. Performance of the ?basic? model (without efferent activity) on a connected digit recognition task is good when the speech is uncorrupted by noise but falls when noise is present. However, recognition performance is much improved when efferent activity is applied. Furthermore, optimal performance is obtained when the amount of efferent activity is proportional to the noise level. The results obtained are consistent with the suggestion that efferent suppression causes a ?release from adaptation? in the auditory-nerve response to noisy speech, which enhances its intelligibility

Multiangle observations of Arctic clouds from FIRE ACE: June 3, 1998, case study

In May and June 1998 the Airborne Multiangle Imaging Spectroradiometer (AirMISR) participated in the FIRE Arctic Cloud Experiment (ACE). AirMISR is an airborne instrument for obtaining multiangle imagery similar to that of the satellite-borne MISR instrument. This paper presents a detailed analysis of the data collected on June 3, 1998. In particular, AirMISR radiance measurements are compared with measurements made by two other instruments, the Cloud Absorption Radiometer (CAR) and the MODIS airborne simulator (MAS), as well as to plane-parallel radiative transfer simulations. It is found that the AirMISR radiance measurements and albedo estimates compare favorably both with the other instruments and with the radiative transfer simulations. In addition to radiance and albedo, the multiangle AirMISR data can be used to obtain estimates of cloud top height using stereoimaging techniques. Comparison of AirMISR retrieved cloud top height (using the complete MISR-based stereoimaging approach) shows excellent agreement with the measurements from the airborne Cloud Lidar System (CLS) and ground-based millimeterwave cloud radar

The molecular control of tomato fruit quality traits: the trade off between visual attributes, shelf life and nutritional value

Tomato (Solanum lycopersicum) is an established model to study fleshy fruit development and ripening and is an important crop in terms of its economic and nutritional value. Tomato fruit quality is a function of metabolite content which is prone to physiological changes related to fruit development and ripening. It has been described some ripening tomato mutants, delayed fruit deterioration (DFD), non-ripening (NOR) and ripening-inhibitor (RIN) which substantially extend “shelf life” in tomato for up to several months when defined in terms of softening, water loss and resistance to postharvest biotic infection. However, it is not known whether this extension in “shelf life” is in fact a desirable objective from the perspective of nutritional quality of the fruits. The aim of this work was to use a metabolomics approach join to genomic tools to characterize compositional changes (sugars, amino acids, organic acids and carotenoids) of non-softening tomato mutants reported (DFD, NOR and RIN) in comparison with the normally softening fruits (Ailsa Craig and M82) during ripening and postharvest shelf-life. Important results related with ripening gene expression and metabolic evolutions are shown

The Grail theorem prover: Type theory for syntax and semantics

As the name suggests, type-logical grammars are a grammar formalism based on logic and type theory. From the prespective of grammar design, type-logical grammars develop the syntactic and semantic aspects of linguistic phenomena hand-in-hand, letting the desired semantics of an expression inform the syntactic type and vice versa. Prototypical examples of the successful application of type-logical grammars to the syntax-semantics interface include coordination, quantifier scope and extraction.This chapter describes the Grail theorem prover, a series of tools for designing and testing grammars in various modern type-logical grammars which functions as a tool . All tools described in this chapter are freely available

The effect of cash injections: evidence from the 1980s farm debt crisis

What is the effect of cash injections during financial crises? Exploiting county-level variation arising from random weather shocks during the 1980s Farm Debt Crisis, we analyze and measure the effect of local weather-driven cash flow shocks on the real and financial sector. We show that such cash flow shocks have significant impact on a host of economic outcomes, including land values, loan delinquency rates, the probability of bank failure, employment, and wages. Estimates of the effect of local cash flow shocks on county income levels during the financial crisis yield a multiplier of 1.63

Association between match activity variables, measures of fatigue and neuromuscular performance capacity following elite competitive soccer matches

The aim of the study was to assess the relationships between match activity variables, subsequent fatigue and neuromuscular performance capacity in elite soccer players. Subjects (n = 10) were professional soccer players participating in the English Championships. Match activity variables and markers of fatigue status were measured before and following two matches. Creatine kinase (CK) and muscle soreness were measured at baseline, immediately following, as well as 40 and 64 h post-match. Countermovement jump performance and perceived ratings of wellness were measured at baseline, then 40 and 64 h post-match. Relationships were shown between CK and the total number of accelerations and decelerations immediately (r = 0.63; large), 40 h (r = 0.45; moderate) and 64 h post-match (r = 0.35; moderate) (p < 0.05). Relationships between CK and total sprint distance (r = 0.39; moderate) and the number of sprints (r = 0.35; moderate) 40 h post-match (p < 0.05) were observed. Furthermore, relationships were shown between the perceived rating of wellness and number of accelerations 40 (r = 0.52; large) and 64 h (r = 0.40; moderate) post-match, sprint distance 40 h post-match (r = 0.40; moderate) and the total number of sprints 40 h post-match (r = 0.51; large) (p < 0.05). The quantification of match activity variables, particularly the total number of accelerations and decelerations and the number of sprints, provides insights into the fatigue status in elite soccer players 40 and 64 h post-match

Toxoplasma effectors targeting host signaling and transcription

Early electron microscopy studies revealed the elaborate cellular features that define the unique adaptations of apicomplexan parasites. Among these were bulbous rhoptry (ROP) organelles and small, dense granules (GRAs), both of which are secreted during invasion of host cells. These early morphological studies were followed by the exploration of the cellular contents of these secretory organelles, revealing them to be comprised of highly divergent protein families with few conserved domains or predicted functions. In parallel, studies on host-pathogen interactions identified many host signaling pathways that were mysteriously altered by infection. It was only with the advent of forward and reverse genetic strategies that the connections between individual parasite effectors and the specific host pathways that they targeted finally became clear. The current repertoire of parasite effectors includes ROP kinases and pseudokinases that are secreted during invasion and that block host immune pathways. Similarly, many secretory GRA proteins alter host gene expression by activating host transcription factors, through modification of chromatin, or by inducing small noncoding RNAs. These effectors highlight novel mechanisms by whichhas learned to harness host signaling to favor intracellular survival and will guide future studies designed to uncover the additional complexity of this intricate host-pathogen interaction

Thoracic duct fistula and renal transplantation

Thoracic duct drainage (TDD) was established for 21-115 days in 40 kidney recipients with an average removal per patient day of 4.7 1 lymph and 1.88 billion cells. Cellular and humoral immunity were depressed. TDD and immunosuppressive drugs were started at transplantation in 35 recipients of cross-match negative grafts. Although the results were better than in precedent non-TDD controls, eight patients rejected their grafts before a full TDD effect, and three of the eight developed predominantly anti-B lymphocyte cytotoxic antibodies which were probably responsible for positive cross-matches with their next donors. With continuing TDD, all eight patients had good initial function after early retransplantation. In five more 'nontransplantable' patients with performed cytotoxic antibodies, TDD was started 30-56 days before transplantation. In these five pretreated patients, antibodies persisted with positive antidonor cross-matches. Hyperacute rejection occurred repeatedly in two patients with high anti-T (and anti-B) titers, but was surmounted in three patients with lower titers. From the clinical and immunologic data, we have concluded that TDD should be used for pretreatment of all cases with or without prior antibodies, and have suggested an adjustable management plan that takes into account new developments in antibody monitoring