High dispersive and monolithic 100% efficiency grisms

We present a type of grism, a series combination of transmission grating and prism, in which we reduce the number of diffraction orders and achieve a configuration with very high angular dispersion. The grism can be fabricated from a single dielectric material and requires no metallic or dielectric film layers for high transmission diffraction efficiency. One can reach 100% in the -1st transmission diffraction order and the equal damage threshold as the dielectric bulk material. We realized such an element in fused silica with an efficiency of more then 99%. The bevel backside reflection is reduced by a statistical antireflective structure, so we measured an efficiency of the entire grism of 95% at a single wavelength

PMT Test Facility at MPIK Heidelberg and Double Chooz Super Vertical Slice

Proceedings supplement for conference poster at Neutrino 2010, Athens, Greece

The freshwater crayfish Austropotamobius pallipes in South Tyrol. Heritage species and bioindicator

Rapid decline of crayfish in European freshwaters and continuing threat necessitate integrated actions in conservation and management of native crayfish populations. Besides biological reasons (diseases, plague), the impact of toxic and harmful substances (fertilisers, herbicides) or wastewater effluents, habitat alteration or fragmentation have been responsible for their decline in some regions. The same is true for the region of South Tyrol, where compared to previous investigations, only 10 of a former total of 15 crayfish locations in the water bodies could be affirmed. Although two new populations of the non-indigenous Astacus astacus were detected, the native Austropotamobius pallipes continues to decline. While many investigations have focused accurately on causal coherences for the decline of native populations, the properties of crayfish facilitate to reverse the situation. In a few examples, the potential of Austropotamobius pallipes, the native crayfish in South Tyrol, as “surrogate species” for effective biological conservation is discussed. Given the various adequate attributes of freshwater crayfish as surrogate species (including indicator species, umbrella species and flagship species qualities), they may help to advance not only the crayfish situation itself but also freshwater ecosystem properties in general

Designing robust and reliable timestamps for remote patient monitoring

This article has been made available through the Brunel Open Access Publishing Fund.Having timestamps that are robust and reliable is essential for remote patient monitoring in order for patient data to have context and to be correlated with other data. However, unlike hospital systems for which guidelines on timestamps are currently provided by HL7 and IHE, remote patient monitoring platforms are: operated in environments where it can be difficult to synchronize with reliable time sources; include devices with simple or no clock; and may store data spanning significant periods before able to upload. Existing guidelines prove inadequate. This paper analyses the requirements and the operating scenarios of remote patient monitoring platforms and defines a framework to convey information on the conditions under which observations were made by the device and forwarded by the gateway in order for data to be managed appropriately and to include both reference to local time and an underlying continuous reference timeline. We define the timestamp formats of HL7 to denote the different conditions of operation and describe extensions to the existing definition of the HL7 timestamp to differentiate between time local to GMT (+0000) and UTC or NTP time where no geographic time zone is implied (-0000). We further describe how timestamps from devices having only simple or no clocks might be managed reliably by a gateway to provide timestamps that are referenced to local time and an underlying continuous reference timeline. We extend the HL7 message to include information to permit a subsequent receiver of the data to understand the quality of the timestamp and how it has been translated. We present evaluation from deploying a platform for 12 months

Collisions of Slow Highly Charged Ions with Surfaces

Progress in the study of collisions of multiply charged ions with surfaces is reviewed with the help of a few recent examples. They range from fundamental quasi-one electron processes to highly complex ablation and material modification processes. Open questions and possible future directions will be discussed.Comment: 13 pages, 16 figures, review pape

Forward Vaccinology: CTL Targeting Based upon Physical Detection of HLA-Bound Peptides

Vaccine-elicited cytotoxic T lymphocytes (CTL) recognizing conserved fragments of a pathogen’s proteome could greatly impact infectious diseases and cancers. Enabling this potential are recent advances in mass spectrometry that identify specific target peptides among the myriad HLA-bound peptides on altered cells. Ultrasensitivity of these physical detection methods allows for the direct assessment of peptide presentation on small numbers of tissue-derived cells. In addition, concurrent advances in immunobiology suggest ways to induce CTLs with requisite functional avidity and tissue deployment. Elicitation of high-avidity resident-memory T cells through vaccination may shift the vaccinology paradigm both for preventive and therapeutic approaches to human disease control