Eksplorasi Agen Kemoterapi Non Toksik: Kajian Terhadap Riset Kurkumin, Turunan Dan Analog Kurkumin, Serta Senyawa Lain Bersumber Dari Tanaman

Tanaman Indonesia mengandung senyawa-senyawa yang berpotensi untuk dikembangkan sebagai agen kemoterapi yang bersifat non toksik, selektif dan aman. Modifikasi senyawa dari tanaman menjadi turunan dan analognya dapat meningkatkan sifat farmakologis, fisik dan kimia dari senyawa induk. Pengembangan kurkumin menjadi PGV-1 dapat menjadi model pengembangan senyawa dari tanaman Indonesia untuk dijadikan sebagai agen kemoterapi. Untuk meningkatkan sifat farmaklogis, sifat fisik dan sifat kimia senyawa tersebut dapat pula dilakukan dengan perbaikan formula antara lain dengan teknik nanoformulasi maupun dengan formulasi untuk terapi tertarget. Pemanfaatan dari senyawa-senyawa tersebut dapat dimanfaatkan baik sebagai kombinasi maupun sebagai agen tunggal

Review Artikel: Pengaruh Metode Ekstraksi Terhadap Profil Metabolit Sekunder Bangle Hantu (Zingiber ottensii Val.)

Non-medical treatment using herbal plants is still the choice of many traditional communities in Indonesia. Black bangle (Zingiber ottensii Val.) is a herbal plant that has many benefits for treating various diseases. One of the main compounds of black bangle (Zingiber ottensii Val.) which has a lot of pharmacological activity is zerumbone. This literature review aims to compare the extraction methods on their effect on the profile of secondary metabolites of black bangle (Zingiber ottensii Val.), so that the method to obtain the best zerumbone levels can be found. In the preparation of this literature review, articles from electronic databases such as PubMed were carried out with the keywords (“Zingiber” OR “ottensii”) AND (“extraction method” OR “extract*”) and through Google Scholar with the keywords (“Zingiber ottensii”) AND (“extraction method” OR "extract*") AND (“secondary metabolites”). There were 396 articles published between 2015-2020. Then the inclusion criteria were determined, namely the tested plants came from the Zingiberaceae family, mentioned the extraction method and there was zerumbone in the profile analysis of the extracted compounds. Exclusion criteria were also determined, namely article in the form of a review article, articles published before 2015, and did not mention zerumbone in the analysis of the extracted compound. The final results were 8 articles that met the inclusion criteria and were ready to be reviewed. The results of the analysis showed that a good extraction method used to obtain the main secondary metabolite (zerumbone) from black bangle rhizome (Zingiber ottensii Val.) is microwave-assisted extraction (MAE)

Tinjauan Artikel : Aktivitas Antidiabetes Antosianin

Diabetes is a chronic metabolic disease which characterized by increased blood sugar levels. The prevalence of diabetes sufferers in Indonesia in 2013 was 6.9% and increased by 8.5% in 2018. Increased use of diabetes drugs has the potential to increase side effects. Some of the side effects often experienced by diabetes patients are nausea and hypoglycemia. Therefore, a new focus is needed to overcome the side effects that occur, one of which is to use traditional medicine. There have been many studies on plants that have antidiabetic activity with compounds that play an active role, namely terpenoid flavonoids and saponins. One group of flavonoid is an anthocyanin that has been widely studied for its properties, including anti-cancer and antidiabetic properties. This literature review aims to determine the effectiveness of anthocyanins as antidiabetic agents. This literature review is obtained from articles searched through the PubMed database, using the keyword "anthocyanins and antidiabetic activity". Some of the inclusion criteria were in vitro studies and primary articles with the publication year 2016-2020. From these results, 7 articles that met the criteria were determined and used as reviews. Based on the analysis, the anthocyanin compoundsfound in plants have pharmacological activity as an antidiabetic agent with several mechanis

Literature Review : Aktivitas Antikanker Payudara Bawang Dayak (Eleutherine bulbosa (Mill.) Urb.)

Dayak onions have been widely studied for their activity in inhibiting the growth of cancer cells. The purpose of this literature review is to examine the anticancer activity of dayak onions plants extracts and their mechanisms in inhibiting the growth of cancer cells. The method used in article search is using the PubMed and Google Scholar databases with the type of literature being analyzed, namely research on the cytotoxic activity of dayak onions plant extracts using the keywords ("Eleutherine" or “dayak onions”) and ("cancer" or “cytotoxicity”). The inclusion criteria used were journals containing cytotoxic or breast anticancer tests of the dayak onions plant with the publication year 2011-2020, and full text journals. The exclusion criteria used were journals about the combination of dayak onions plant extracts with other plants, there was no IC50 value, and journals about review articles, abstracts, or books. The result of the analysis showed that the content of the dayak onion extract contained isoliquiritigenin and eleutherine compound which a role in the inhibition of breast cancer