Non-medical treatment using herbal plants is still the choice of many traditional communities in Indonesia. Black bangle (Zingiber ottensii Val.) is a herbal plant that has many benefits for treating various diseases. One of the main compounds of black bangle (Zingiber ottensii Val.) which has a lot of pharmacological activity is zerumbone. This literature review aims to compare the extraction methods on their effect on the profile of secondary metabolites of black bangle (Zingiber ottensii Val.), so that the method to obtain the best zerumbone levels can be found. In the preparation of this literature review, articles from electronic databases such as PubMed were carried out with the keywords (“Zingiber” OR “ottensii”) AND (“extraction method” OR “extract*”) and through Google Scholar with the keywords (“Zingiber ottensii”) AND (“extraction method” OR "extract*") AND (“secondary metabolites”). There were 396 articles published between 2015-2020. Then the inclusion criteria were determined, namely the tested plants came from the Zingiberaceae family, mentioned the extraction method and there was zerumbone in the profile analysis of the extracted compounds. Exclusion criteria were also determined, namely article in the form of a review article, articles published before 2015, and did not mention zerumbone in the analysis of the extracted compound. The final results were 8 articles that met the inclusion criteria and were ready to be reviewed. The results of the analysis showed that a good extraction method used to obtain the main secondary metabolite (zerumbone) from black bangle rhizome (Zingiber ottensii Val.) is microwave-assisted extraction (MAE)
