Formulasi Sediaan Gel Antiseptik Tangan Minyak Atsiri Jeruk Lemon (Citrus Limon (L) Burm. F) Dengan Basis Karbopol Dan Aktivitas Antibakteri Terhadap Staphylococcus Aureus

Minyak atsiri jeruk lemon (Citrus limon (L.) Burm. f.) mempunyai aktivitas antibakteri terhadap Staphylococcus aureus, sehingga dapat digunakan sebagai zat aktif dalam antiseptik tangan. Tujuan penelitian ini adalah untuk mengetahui aktivitas antibakteri minyak atsiri jeruk lemon terhadap Staphylococcus aureus setelah diformulasikan dalam bentuk gel dan mengetahui pengaruh penambahan minyak atsiri terhadap aktivitas antibakteri dan sifat fisik gel. Formula 1 dibuat tanpa penambahan minyak atsiri, sedangkan formula 2 - 4 dibuat dengan konsentrasi minyak atsiri , , dan . Data dianalisis dengan uji anova satu jalan dilanjutkan dengan uji t-LSD dengan taraf kepercayaan 95%. Hasil penelitian menunjukkan bahwa gel antiseptik tangan minyak atsiri jeruk lemon mempunyai aktivitas antibakteri terhadap Staphylococcus aureus. Peningkatan kadar minyak atsiri jeruk lemon dapat meningkatkan aktivitas antibakteri terhadap Staphylococcus aureus, daya sebar, pH, dan menurunkan viskositas dari sediaan gel

Optimasi Kombinasi Matriks Natrium Alginat Dan Hydroxypropyl Methylcellulose Untuk Tablet Lepas Lambat Kaptopril Dengan Sistem Mucoadhesive

Kaptopril merupakan obat golongan ACE inhibitor yang digunakan untuk pengobatan hipertensi dan gagal jantung. Waktu paruh kaptopril yang pendek yaitu 1-3 jam, cocok untuk didesain menjadi sediaan lepas lambat yang dapat bertahan dilambung dalam waktu yang diperlama. Penelitian ini bertujuan untuk mengetahui pengaruh kombinasi HPMC dan natrium alginat sebagai matriks terhadap sifat alir granul, sifat fisik dan profil disolusi tablet kaptopril sistem mucoadhesive, serta untuk mendapatkan formula optimum. Tablet dibuat lima formula dengan perbandingan HPMC : natrium alginat FI (100% : 0%), FII (75% : 25%), FIII (50% : 50%), FIV (25% : 75%), dan F5 (0% : 100%) dengan menggunakan metode granulasi basah. Uji yang dilakukan yaitu sudut diam granul, keseragaman bobot, kekerasan, kerapuhan, mucoadhesive, keseragaman kandungan dan disolusi tablet. Data dianalisis dengan program Design Expert 8.0.5 (trial) model Simplex Lattice Design (SLD). Hasil penelitian menunjukkan bahwa semakin banyak natrium alginat dapat menaikkan sudut diam, memperburuk keseragaman bobot, dan menaikkan daya lekat tablet sedangkan semakin banyak HPMC dapat meningkatkan kerapuhan tablet dan kecepatan disolusi. Formula optimum diperoleh dari perbandingan konsentrasi HPMC : Natrium alginat (25% : 75%)

Formulasi Sediaan Krim Ekstrak Etanol Herba Patikan Kebo (Euphorbia hirta L.) Dengan Basis Krim Tipe M/A Dan Uji Aktivitas Antibakteri Terhadap Pseudomonas aeruginosa Secara In Vitro

Ekstrak herba patikan kebo (Euphorbia hirta L.) mempunyai aktivitas antibakteri, salah satunya dapat dimanfaatkan sebagai obat infeksi yang terjadi pada luka bakar terhadap Pseudomonas aeruginosa. Dalam mempermudah pengggunaanya, maka dibuat ke dalam bentuk sediaan krim. Tujuan penelitian ini adalah mengetahui pengaruh formulasi krim ekstrak herba patikan kebo terhadap sifat fisik dan aktivitas antibakterinya terhadap Pseudomonas aeruginosa. Ekstrak herba patikan kebo diperoleh dari proses maserasi menggunakan pelarut etanol 96%. Krim dibuat dengan perbedaan konsentrasi ekstrak 4%, 6%, 8%, dan 10%. Krim yang diperoleh di uji sifat fisik (organoleptis, viskositas, pH, daya lekat, dan daya sebar) dan aktivitas antibakteri pada Pseudomonas aeruginosa. Analisis data digunakan uji anova satu jalan. Hasil uji sifat fisik krim menunjukkan dengan adanya kenaikan konsentrasi ekstrak akan meningkatkan viskositas, daya lekat, dan menurunkan daya sebar krim. Uji organoleptis (bentuk, warna, dan bau) dan pH menunjukkan hasil stabil pada sediaan krim, sedangkan untuk viskositasnya cukup stabil selama penyimpanan. Krim dengan ekstrak patikan kebo mempunyai aktivitas antibakteri terhadap Pseudomonas aeruginosa dengan zona hambat berturut-turut 8,0±0,46 mm, 8,94±0,48 mm, 10,31±0,46 mm, 10,09±0,38 mm pada penambahan ekstrak 4%, 6%, 8%, dan 10%

Formulasi Sediaan Krim Ekstrak Etanol Buah Mahkota Dewa (Phaleria macrocarpa (SCHEFF.) BOERL) Basis Cold Cream Dan Uji Aktivitas Antibakteri Terhadap Staphylococcus epidermidis

Ethanolic extract of mahkota dewa fruit (Phaleria macrocarpa (Scheff.) Boerl) has a content of flavonoid, saponin and tannin as antibacterial. Ethanolic extract should be formulated in cream to make it easier function. This present study aimed to determine difference proportion of cetaceum and cera alba on physical characteristics, physical stability cream and antibacterial activity Staphylococcus epidermidis. Mahkota dewa fruit was conducted by soxhletation using ethanol 96%. The evaluation of cream consisted of viscosity, pH, spread ability, adhesiveness, physical stability with freeze thaw cycling and antibacterial with diffusion method. Antibacterial activity could be seen from the resulting inhibition zone. Analyzing of data used anova to know the effect compare proportion of cetaceum and cera alba to the physical characteristic, multivariate test to know physical stability of the cream and paired sample t-test to know the effect freeze thaw cycling to antibacterial activity. The results showed that there was proportion of cetaceum and cera alba on formula affected the viscosity, adhesiveness, and spread ability showed p-value <0,05. Physical stability with freeze thaw cycling method showed a steady to cycle 2. Antibacterial activity of cream ethanolic extract mahkota dewa unchanged after freeze thaw cycling

Comparison Of Quality Of Physical Tablet Metformin Hydrochloride Trademark And Generic

Patent drugs are drugs that have recently been found by research and have the patent duration depends on the type of the medication. After a period of patented drugs to stop his patents, patent medicines and then later referred to as a generic drug. Most people assume that quality drugs are drugs that are expensive like product trademark. One example of a trademark drug and the generic drug metformin hydrochloride tablets is an oral antidiabetic medication. The test of physical characteristic was done in this research concludes the test of weight uniformity, thickness tablets, diameter, hardness tester, friability tester and disintegration tester. The result of the data are considered with the rules and regulation of Indonesian farmakope and the other books. The research result show products generic and products are trade having the difference in violence and time destroyed tablet but have in common in test uniformity weight, thickness, diameter, and friability tester. The quality of physical tablet metformin hydrochloride to the generic and a trade have met the requirements in control of the quality of tablet

Formulasi Sediaan Krim Minyak Atsiri Kayu Manis (Cinnamomum burmannii) Dengan Basis Vanishing Cream Dan Uji Aktivitas Antibakterinya Terhadap Staphylococcus epidermidis

One of the potential causes of acne is bacterium Staphylococcus epidermidis. Cinnamon essential oil contains sinamaldehid and eugenol which has benefit as an anti-bacterial agent. This study has purpose to determine the effect of cera alba and vaselinum album proportion on the physical properties, physical stability, anti bacterial activity toward Staphylococcus epidermidis. The essential oil of cinnamon was obtained by steam distillation. The chemical content of sinamaldehid and eugenol in the essential oil was tested by using TLC. The formula of cream was made with various composition of variation cera alba : vaselinum album. They were F1 (30%:70%), F2 (40%:60%), F3 (50%:50%), F4 (60%:40%), and F5 (70%:30%) respectively. The test of the physical properties of cream includes viscosity, spreadibility, adhesion, and the test of physical stability of cream has done by using freeze thaw cycling. The test of anti-bacterial activity was performed by pitting diffusion method. The effect of freeze thaw was analyzed by using multivariate analysis, the physical properties were analyzed by using anova test, the antibacterial test of before and after freeze thaw and the test of physical stability of cream in the cycle of 0 and 6 were analyzed by using paired sample t-test. The results indicate that the cream increased in viscosity and adhesion, decreased cream spreadibility, by the increase of cera alba in cream. Freeze thaw cycling test caused lowering viscosity of all formulas and decreasing spreadibility of F2, but increasing adhesion of F1. There is no different of antibacterial activity before and after freeze thaw cycling test

Formulasi Sediaan Krim Ekstrak Etanol Buah Mahkota Dewa (Phaleria macrocarpa (Scheff.) Boerl) Dengan Basis Vanishing Cream Dan Uji Aktivitas Antibakteri Terhadap Staphylococcus epidermidis

Mahkota dewa fruits (Phaleria marcrocarpa (Scheff.)Boerl) is one of medicinal plants as a traditional medicine for acne. The ethanolic extract of Phaleria contained flavonoids and saponins as an antibacterial agent. This research aims to made cream with Phaleria fruit ethanolic extract and had to known of antibacterial activity cream against Staphylococcus epidermidis. Soxhletation method used to make ethanol extract of Phaleria fruit. The TLC and qualitative tests were used for test of containing extracts. The extract would be used to made cream with vanishing cream base and a comparison the proportion of tween 80 and span 80 as emulsifier. Then, cream was tested in an antibacterial activity and physical stability test used freeze-thaw cycling method. The results showed that the addition proportion of Tween 80 in the formula increase viscosity and adhesiveness, and lower spreadability. ANOVA test results on the physical properties of the cream obtained p-value 0.00 < 0.05, which mean a difference physical cream test were affected by differences in the concentration of emulsifier. The results of stability test cream with freeze-thaw cycling method showed that cream only stable until second cycle. Results of the test cream antibacterial activity had an irradikal diameter of bacterial inhibition zone Antibacterial test before and after freeze-thaw cycling had p-value >0.05, which means there’s no effect of stability test on antibacterial activity

Formulasi Sediaan Sabun Wajah Minyak Atsiri Kayu Manis(Cinnamomum burmanni Nees Ex. Bl.) DanUji Aktivitas Antibakteri TerhadapStaphylococcus epidermidis

Essential oil of cinnamon (Cinnamomum burmanni) containing sinamaldehid and eugenol has benefit as antibacterial. The essential oil is formulated in the form of facial soap to simplify the application. The facial soap of cinnamon essential oil can be used to prevent acne caused by the bacterium of Staphylococcus epidermidis. The purpose of this study was to determine the effect of cocamidopropyl betaine and glycerin usage on the physical properties and the physical stability of facial soap dosage and the antibacterial activity of Staphylococcus epidermidis. The formula facial of facial soap was made with a composition ratio of cocamidopropyl betaine and glycerin at Formula 1 (7:3), Formula 2 (6:4), Formula 3 (5:5), Formula 4 (4:6) and Formula 5 (3:7). The concentration of cinnamon essential oil used was 4%v/v. The test of the facial soap physical properties consits of pH, viscosity, foam height, specific gravity and alkali-free levels. The physical stability was tested by using the freeze thaw cycling. The bacterial activity was tested by using the pitting diffusion method. The research results of the physical properties test indicated an increaseon the composition of glycerine causing an increase of viscosity and an specific gravity. The results of physical stability test with the freeze thaw cyclingindicated a not significant decline (p-value> 0.05). The dosage of cinnamon essential oil facial soap indicated a decrease in the diameter of inhibitory zone after the freeze thaw cycling

Formulation Ointment Preparation Basil Essential Oil ( Ocimum Basilicum L. ) Antibacterial Activity And Test ON Staphylococcus Aureus

Basil essential oil contains linalool compounds that capable of inhibiting the growth of Staphylococcus aureus. Essential oil is formulated in order to facilitate ointment application on the skin and prevent evaporation. This study was conducted to determine the physical properties, antibacterial activity and stability of basil essential oil ointment after 3 months storage. Basil essential oil was used as active compounds with concentration of 12.5%. Ointment with varying concentration of PEG 4000 : PEG 400 with ratio of 40%: 60% (F1), 30% : 70% w/v (F2), 20% : 80% (F3), and 10% : 90% (F4) were made. Ointment stability tests were conducted over 3 months includes organoleptic, pH, viscosity, spreadibility, adhesion, globules size, and freeze thaw for 6 cycles. Antibacterial activity test was conducted using well diffusion agar method. Data were analyzed by one-way ANOVA and Kruskal-Wallis. The results showed that the decrease of PEG 4000 and increase of PEG 400 decreased viscosity and adhesion, increased the spread but ointments pH were stable. Ointments that were storaged for 3 months have stable pH, lower adhesion and viscosity, but higher spreadibility than that of before storage. In the freeze thaw test, only F4 was unstable. Antibacterial activity of ointment against Staphylococcus aureus showed that ointment have greater inhibitory zones than the base, average ointment inhibitory zone is 21.49 mm

Formulation Face Soap Essential Oil Stocks Basil (Ocimum Basilicum L.) With Combined Sodium Lauryl Sulfate And Glycerin And Test Antibacterials Of Staphylococcus Epidermidis

Basil essential oil containing linalool has antibacterial activity against Staphylococcus epidermidis which cause acne. Essential oil can be formulated to facilitate its use as anti- acne, one of the dosage form is facial soap. This study aimed to determine the physical properties, stability, and the antibacterial activity of facial soap containing basil oil. Facial soaps contain 12,5% v/v basil essential oil were made in four formulas with concentrations of sodium lauryl sulfate (SLS) and glycerin of 20% (F1), 25% (F2), 30% (F3), and 35% (F4). Facial soap were tested for physical properties and physical stability for 3 months includes organoleptic, viscosity, dispersive capability, foam height, pH, globules size, freeze-thaw test for 6 cycles, and antibacterial activity with diffusion method. Data were analyze using Kruskal-Wallis test and one way ANOVA. Results of physical properties test of facial soap showed a significant increase in viscosity and significant reduction in the dispersive capability, but not significant in the foam height. Stability test of facial soap showed a significant increase in the dispersive capability of F2 and F4, but not significant in F1 and F3, as well as a significant increase in the globules size on freeze-thaw test. The viscosity decreased not significantly in three months storage and freeze-thaw test. Foam height and globule size increase were not significant. Antibacterial activity of facial soap decreased not significantly in three months storage