The role of urate and xanthine oxidase in vascular oxidative stress:Future directions

Vascular oxidative stress has been shown to be a potent factor in the pathophysiology of endothelial dysfunction. Despite current optimal evidence-based therapy, mortality from various cardiovascular disorders remains high. The search for newer, novel ways of attenuating endothelial dysfunction has yielded several new and exciting possibilities, one of which is the manipulation of urate levels using xanthine oxidase inhibitors. Agents such as allopurinol have shown marked improvements in vascular endothelial function in various cohorts at risk of cardiovascular events. Most of the evidence so far comes from smaller mechanistic studies. The few large randomized controlled trials have failed to show any significant mortality benefit using these agents. This article highlights the potential avenues of further research such as dose-response, and the potential for these agents to regress left ventricular hypertrophy. The role of newer agents such as febuxostat and oxypurinol are discussed as well as potential reasons why some of the current newer agents have failed to live up to the promising early-phase data. It is crucial that these remaining questions surrounding urate, xanthine oxidase and the role of various agents that affect this important oxidative stress-generating system are answered, and therefore these promising agents should not be discarded prematurely

Role of urate, xanthine oxidase and the effects of allopurinol in vascular oxidative stress

Oxidative stress plays an important role in the progression of vascular endothelial dysfunction. The two major systems generating vascular oxidative stress are the NADPH oxidase and the xanthine oxidase pathways. Allopurinol, a xanthine oxidase inhibitor, has been in clinical use for over 40 years in the treatment of chronic gout. Allopurinol has also been shown to improve endothelial dysfunction, reduce oxidative stress burden and improve myocardial efficiency by reducing oxygen consumption in smaller mechanistic studies involving various cohorts at risk of cardiovascular events. This article aims to explain the role of xanthine oxidase in vascular oxidative stress and to explore the mechanisms by which allopurinol is thought to improve vascular and myocardial indices

Using the Internet for Organizational Research: A Study of Cynicism in the Workplace

The Internet can be a valuable data collection tool for organizational psychology researchers. It can be less expensive than traditional paper-and-pencil survey methods, and the potential pool of participants is much larger. In addition, it can be used in situations where traditional data collection methods are not feasible, such as research involving sensitive issues such as negative employee attitudes or deviant behaviors at work. In this study, we examined the organizational attitudes of employees from various companies using (a) a snowball sample, who completed a traditional paper and pencil survey (n = 135), and (b) a sample recruited over the Internet, who completed an on-line survey (n = 220). Participants in both the non- Internet and the Internet group were asked to describe a negative incident involving their company, and answer a number of questions regarding how they felt about their company and how they behaved toward their company following the negative event. They also completed measures of organizational cynicism and job satisfaction. The two groups were compared on demographic characteristics and on their attitudes toward their organization. There were very few demographic differences between the two groups. The Internet group tended to be more cynical and to judge their organization more harshly than the non-Internet group; however, the response patterns of both groups were similar. These results suggest that, when used with caution, the Internet can be a viable method of conducting organizational research

Measuring the Circle: Emerging Trends in Philanthropy for First Nations

The Circle had the opportunity to undertake a multi-part research project to gain a more robust understanding of non-governmental funding to Aboriginal beneficiaries and causes in Canada over the past few years. The year-long knowledge gathering process included three inter-related activities: (a) mining Canada Revenue Agency data to map the Aboriginal funding economy in Canada from 2005 to 2011; (b) a set of Key Informant interviews with representatives from a sample of grantmakers surfaced through the mapping activity; and (c) a series of case studies to showcase some leading funders in the Aboriginal funding sphere or initiatives dedicated to building community capacity as well as supporting Aboriginal beneficiaries and causes. This report contains the key findings from the three-part research initiative

HIV counselling and testing in secondary schools: what students want

Background: HIV counselling and testing (HCT) is an essential element in the response to the HIV epidemic. There are still major research gaps about the best ways to provide HCT, especially to the youth, and school-based HCT is a model that has been suggested. To make HCT youth friendly and to enhance access to the service, the particular needs of the youth need to be addressed. Aim: To explore the expressed needs of students about school-based HCT service provision. Method: The study was conducted in 6 secondary schools in Cape Town where a mobile HCT service is provided by a non-governmental organisation. In each school, two mixed gender focus groups were held, one with grades 8 and 9 students and one with grades 10 and 11. A total of 91 students aged 13-21 were involved. The focus groups were conducted in the students' home language. All groups were audio-recorded, transcribed verbatim and translated into English. Results: Content data analysis was done and the following themes emerged: (1) Where the students want HCT to be done, (2) How they want HCT to be done and (3) Who should do the counselling. Most students want HCT to be provided in schools on condition that their fears and expressed needs are taken into account. They raised concerns regarding privacy and confidentiality, and expressed the need to be given information regarding HCT before testing is done. They wanted staff providing the service to be experienced and trained to work with youth, and they wanted students who tested positive to be followed up and supported. Conclusion: To increase youth utilisation of the HCT service, their expressed needs should be taken into account when developing a model for school-based HCT

Association of medical students of South Africa

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