Highly porous photoluminescent diazaborole-linked polymers: synthesis, characterization, and application to selective gas adsorption

The formation of boron–nitrogen (B–N) bonds has been widely explored for the synthesis of small molecules, oligomers, or linear polymers; however, its use in constructing porous organic frameworks remains very scarce. In this study, three highly porous diazaborole-linked polymers (DBLPs) have been synthesized by condensation reactions using 2,3,6,7,14,15-hexaaminotriptycene and aryl boronic acids. DBLPs are microporous and exhibit high Brunauer–Emmett–Teller surface area (730–986 m2 g−1) which enable their use in small gas storage and separation. At ambient pressure, the amorphous polymers show high CO2 (DBLP-4: 4.5 mmol g−1 at 273 K) and H2 (DBLP-3: 2.13 wt% at 77 K) uptake while their physicochemical nature leads to high CO2/N2 (35–42) and moderate CO2/CH4 (4.9–6.2) selectivity. The electronic impact of integrating diazaborole moieties into the backbone of these polymers was investigated for DBLP-4 which exhibits green emission with a broad peak ranging from 350 to 680 nm upon excitation with 340 nm in DMF without photobleaching. This study demonstrates the effectiveness of B–N formation in targeting highly porous frameworks with promising optical properties

An End-to-End Big Data Analytics Platform for IoT-enabled Smart Factories: A Case Study of Battery Module Assembly System for Electric Vehicles

Within the concept of factories of the future, big data analytics systems play a critical role in supporting decision-making at various stages across enterprise processes. However, the design and deployment of industry-ready, lightweight, modular, flexible, and low-cost big data analytics solutions remains one of the main challenges towards the Industry 4.0 enabled digital transformation. This paper presents an end-to-end IoT-based big data analytics platform that consists of five interconnected layers and several components for data acquisition, integration, storage, analytics and visualisation purposes. The platform architecture benefits from state-of-the-art technologies and integrates them in a systematic and interoperable way with clear information flows. The developed platform has been deployed in an Electric Vehicle (EV) battery module smart assembly automation system designed by the Automation Systems Group (ASG) at the University of Warwick, UK. The developed proof-of-concept solution demonstrates how a wide variety of tools and methods can be orchestrated to work together aiming to support decision-making and to improve both process and product qualities in smart manufacturing environments

QuTIE: Quantum optimization for Target Identification by Enzymes

Target Identification by Enzymes (TIE) problem aims to identify the set of enzymes in a given metabolic network, such that their inhibition eliminates a given set of target compounds associated with a disease while incurring minimum damage to the rest of the compounds. This is an NP-complete problem, and thus optimal solutions using classical computers fail to scale to large metabolic networks. In this paper, we consider the TIE problem for identifying drug targets in metabolic networks. We develop the first quantum optimization solution, called QuTIE (Quantum optimization for Target Identification by Enzymes), to this NP-complete problem. We do that by developing an equivalent formulation of the TIE problem in Quadratic Unconstrained Binary Optimization (QUBO) form, then mapping it to a logical graph, which is then embedded on a hardware graph on a quantum computer. Our experimental results on 27 metabolic networks from Escherichia coli, Homo sapiens, and Mus musculus show that QuTIE yields solutions which are optimal or almost optimal. Our experiments also demonstrate that QuTIE can successfully identify enzyme targets already verified in wet-lab experiments for 14 major disease classes

Inferring progression models for CGH data

Motivation: One of the mutational processes that has been monitored genome-wide is the occurrence of regional DNA copy number alterations (CNAs), which may lead to deletion or over-expression of tumor suppressors or oncogenes, respectively. Understanding the relationship between CNAs and different cancer types is a fundamental problem in cancer studies. Results: This article develops an efficient method that can accurately model the progression of the cancer markers and reconstruct evolutionary relationship between multiple types of cancers using comparative genomic hybridization (CGH) data. Such modeling can lead to better understanding of the commonalities and differences between multiple cancer types and potential therapies. We have developed an automatic method to infer a graph model for the markers of multiple cancers from a large population of CGH data. Our method identifies highly related markers across different cancer types. It then builds a directed acyclic graph that shows the evolutionary history of these markers based on how common each marker is in different cancer types. We demonstrated the use of this model in determining the importance of markers in cancer evolution. We have also developed a new method to measure the evolutionary distance between different cancers based on their markers. This method employs the graph model we developed for the individual markers to measure the distance between pairs of cancers. We used this measure to create an evolutionary tree for multiple cancers. Our experiments on Progenetix database show that our markers are largely consistent to the reported hot-spot imbalances and most frequent imbalances. The results show that our distance measure can accurately reconstruct the evolutionary relationship between multiple cancer types. Availability: All the code developed in this article are available at http://bioinformatics.cise.ufl.edu/phylogeny.html. Contact: [email protected]; [email protected] Supplementary information: Supplementary data are available at Bioinformatics onlin

Anomalous Magnetic Ordering in PrBa₂Cu₄O₈ and CmBa₂Cu₃O₇

A review of temperature-dependent magnetization data for nonsuperconducting PrBa2Cu4O8 and CmBa2Cu3O7 suggests that the failure of each to superconduct is related to the presence of Pr and Cm on their respective Ba sites. This defect is manifested, in each case, by short c-axis lattice parameters and anomalous high-temperature magnetic ordering which has been incorrectly attributed to ordering of the entire magnetic sublattice. Instead, it is shown that the anomalous high-temperature ordering as seen in the magnetization data is consistent with the ordering of magnetic ions substituted on the Ba site

Ektopik Gebelik Olgularında Methotrexatın Tedavi Etkinliğinin Değerlendirilmesi

Aim: Our aim in this study was to assess efficacy of singledose methotrexate (MTX) as medical treatment for ectopic pregnancy (EP) by evaluating the results of patients given this treatment. Materials and Methods: Between September 2016 and August 2017, the treatment outcomes of EP cases treated with MTX at Gazi Yaşargil Training and Research Hospital of Health Sciences University were evaluated retrospectively. Results: In total, 126 cases treated for EP were evaluated and 65 cases were included in the study. In cases administered a single dose of MTX, the success rate was 80%, the failure rate was 13.8%, and the emergency surgery rate was 6.2%. The overall success rate of the medical treatment was 90.7% for a second dose of MTX. An unsuccessful result was considered as less than a 15% reduction in the beta-human chorionic gonadotropin (?-hCG) level between 4 and 7 days after single dose MTX administration. In all cases, the rate of emergency surgery after treatment was 9.3%. Conclusions: In our study, success rates in patients with EP treated with MTX were 80% after a single dose and as high as 90.7% when a second dose was addedAmaç: Bu çalışmadaki amacımız ektopik gebelik’ te (EP) medikal tedavi olarak tek doz methotrexat (MTX) tedavisi verilen olguların sonuçlarının değerlendirilmesidir. Materyal ve Metot: Eylül 2016 ile Ağustos 2017 arasında Sağlık Bilimleri Üniversitesi Gazi Yaşargil Eğitim ve Araştırma Hastanesinde tedavi edilen EP olgularında MTX tedavisi uygulanmış olanların tedavi sonuçları retrospektif olarak değerlendirildi. Bulgular: Çalışmanın yapıldığı tarihler arasında EP nedeniyle tedavi edilen 126 olgu çalışmaya dahil edildi. Tek doz MTX tedavisi başlanan olgularda başarı oranı %80, başarısızlık %13.8 ve acil cerrahi oranı %6.2 olarak gerçekleşti. Tek doz MTX uygulaması sonrasında 4 ve 7 günler arsında betahuman chorionic gonadotropin (?-hCG) seviyesinin %15 ten az düşmesi sonucunda başarısız olarak kabul edilen olgularda yapılan 2. doz MTX sonucunda, medikal tedavinin toplam başarı oranı %90.7 olarak gerçekleşirken, bu olguların tümünde tedavi sonrası acil cerrahi oranı %9.3 olarak gerçekleşti. Sonuç: Çalışmamızda uygun endikasyonla MTX tedavisi uygulanan EP olgularında medikal tedavinin başarı oranı %90.7 gibi oldukça yüksek bir oranda gerçekleşmiş olup olguların sadece %9.3 de MTX tedavisi sonrasında acil cerrahi tedavi gerekmiştir

The effect of anesthesia type on stress hormone response: Comparison of general versus epidural anesthesia

Aim: The aim of this study was to investigate the effect of different types of anesthesia on stress hormones.Materials and Methods: The study was included 60 ASAI-II cases scheduled for major lower extremity surgery. The cases were randomized into 2  groups: The EA group was administered epidural anesthesia and the GA group was administered standard general anesthesia. In order to evaluate the surgical trauma - related stress response, CRP, TSH, cortisol, and fasting blood sugar(FBS) levels were measured preoperatively, 30 min after surgical incision, and 24 h post surgery.Results: Between-group comparisons; Preoperative values were not  significantly different between the groups.(P > 0,05) Pulse rate and cortisol values significantly higher in general group at 30 min. (P < 0,05), and the FBS values were significantly higher in the epidural group at 24 h.(P < 0,05) There were not found differences for other parameters at evaluation times.Conclusion: No differences were observed between the two anesthesia methods, in terms of minimizing the stress response due to surgical trauma during major low extremity surgery.Key words: Epidural anesthesia, general anesthesia, stress hormone

Pyramiding multiple genes for resistance to PVY, TSWV and PMMoV in pepper using molecular markers

Pepper (Capsicum annuum L.) is one of the most important vegetables cultivated worldwide. Many pests and pathogens cause economic yield losses in pepper. Potato virus Y (PVY), Tomato spotted wilt virus (TSWV) and Pepper mild mottle virus (PMMoV) are considered among the most destructive viruses affecting pepper in the world. Because chemical treatments have limited success for managing PVY, TSWV and PMMoV, resistant varieties are considered to be the most effective means of controlling these viruses. In this study, resistance genes to these viruses were successfully transferred to the superior sweet Charleston pepper line 'Y-CAR' using molecular markers and biological assays. As a result, a new line which is resistant to PVY, TSWV and PMMoV was developed. The results also showed the applicability of a pyramiding strategy for breeding multiple virus resistance in pepper. © Verlag Eugen Ulmer KG, Stuttgart.Scientific and Technological Research Council of Turkey, TEYDEP foundation (3080171

Investigation of temporal bone asymmetry in cases with unilateral tinnitus: morphometric and multicentric clinical study

The aim of this multicentric study was to compare the anatomical structures of temporal bone in patients with unilateral tinnitus with their healthy ears. We also aimed at evaluating whether age and gender-related asymmetrical changes occur in temporal bones or not. Fifty two ears of 26 patients who had unilateral tinnitus were included into the retrospective study. The patients who had subjective nonpulsatile tinnitus and who previously had temporal computed tomography according to their file records were accepted to study. Temporal CT scans and audiometric results of patients were examined retrospectively. Middle ear volume, diameter of internal acoustic meats and diameter of jugular bulb were evaluated by both anatomist and radiologist, interobserverly. Internal acoustic meats and jugular bulb were found larger in the ears that had tinnitus than healthy ears; however, there was no statistically significance. The stereological morphometrical study of temporal bone asymmetry in humans correlate with sex is of importance for both otolarygologs and anatomists. These results will contribute to data on middle ear volume, internal acustic meats and jugular bulb sizes

The effect of thrombolytic therapy on QT dispersion in acute myocardial infarction and its role in the prediction of reperfusion arrhythmias

Purpose: We aimed to determine the effect of intravenous thrombolytic therapy on QT dispersion (QTd) and its role in the prediction of reperfusion arrhythmias.Materials and Methods: Twenty patients with acute myocardial infarction (MI) were enrolled in the study. Measurements of QTd were carried out  prior to thrombolytic therapy and before discharge. The patients were examined for ventricular arrhythmias with 24‑h Holter electrocardiography monitoring after treatment and the relationship between ventricular arrhythmias and the QTd values in the early phase of MI was investigated.Results: The values of QTd were significantly higher during the early phase of MI (60 ± 5.32 ms) than those in the late phase (53.35 ± 4.07 ms) (P = 0.032). There was no correlation between isolated, bigeminal, trigeminal and total ventricular premature beats, accelerated idioventricular rhythm (AIVR) with QTd values. However, the patients with sustained ventricular tachycardia (VT), prolonged VT and sustained AIVR had higher corrected QTd (92 ms1/2, 97.8 ms1/2, 81.7 ms1/2, respectively) than the patients without these arrhythmias (74 ms1/2, 56.3 ms1/2, 58.28 ms1/2,  respectively) (P = 0.022, 0.013, 0.018).Conclusion: The values of QTd may be significantly reduced in the 1st week of acute MI and measurement of QTd in the early phase of MI may have a correlation with the following reperfusion arrhythmias: Sustained VT, prolonged VT and AIVR.Key words: Arrhythmia, myocardial infarction, QT dispersion, reperfusion, thrombolytic therap