36,472 research outputs found

    [Review of] Roy Harvey Pearce. Savagism and Civilization: A Study of the Indian and the American Mind. Rev. ed. of The Savages of America

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    This classic volume on the image of the Indian in the American mind first appeared in 1953. Although both limited and incomplete, Pearce\u27s work compelled a virtual revolution in literary and historical approaches to analysis of public view concerning the role of Indians in the American past

    Ligand Discrimination in Myoglobin from Linear-Scaling DFT+U

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    Myoglobin modulates the binding of diatomic molecules to its heme group via hydrogen-bonding and steric interactions with neighboring residues, and is an important benchmark for computational studies of biomolecules. We have performed calculations on the heme binding site and a significant proportion of the protein environment (more than 1000 atoms) using linear-scaling density functional theory and the DFT+U method to correct for self-interaction errors associated with localized 3d states. We confirm both the hydrogen-bonding nature of the discrimination effect (3.6 kcal/mol) and assumptions that the relative strain energy stored in the protein is low (less than 1 kcal/mol). Our calculations significantly widen the scope for tackling problems in drug design and enzymology, especially in cases where electron localization, allostery or long-ranged polarization influence ligand binding and reaction.Comment: 15 pages, 3 figures. Supplementary material 8 pages, 3 figures. This version matches that accepted for J. Phys. Chem. Lett. on 10th May 201

    Dirty Recycling: Auto Salvage and Its Potential Impacts on Marginalized Populations

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    The salvage yard represents the final waypoint in the cradle-to-grave cycle of the automobile. Residual amounts of petroleum hydrocarbons, heavy metals, and acids used in automobiles can be extremely harmful to human health and the environment if not managed correctly. The purpose of this study was to assess the extent to which minority populations were exposed to the hazards of the auto salvage industry. Census data for population, income, race/ethnicity, sex, and age were organized using ArcGIS software. Population demographics were analyzed in the areas surrounding 98 auto salvage yards found in Philadelphia and Adams Counties, Pennsylvania. In Philadelphia County, the results showed that low-income minorities, females, and 65+ individuals are over represented groups near auto salvage yards. Conversely, Adams County showed few spatial relationships in demographic distribution. Our findings suggest that in urban counties, such as Philadelphia, depressed property values have resulted in a large percentage of below average income minorities inhabiting areas in close proximity to auto salvage yards. On the other hand, auto salvage yards in rural areas, such as Adams County, do not appear to have the same effect because population density and racial diversity are much lower

    [Review of] Silvester J. Brito. The Way of a Peyote Roadman

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    The Way of a Peyote Roadman is a work which is certain to stir controversy in a number of academic circles. Silvester J. Brito holds a Ph.D. in folklore and anthropology from Indiana University. The book begins with a personal affirmation of the author\u27s belief in the power of sorcery, based on his personal experiences culminating in a peyote ritual curing ceremony

    Distribution of the very first PopIII stars and their relation to bright z~6 quasars

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    We discuss the link between dark matter halos hosting the first PopIII stars and the rare, massive, halos that are generally considered to host bright quasars at high redshift z~6. The main question that we intend to answer is whether the super-massive black holes powering these QSOs grew out from the seeds planted by the first intermediate massive black holes created in the universe. This question involves a dynamical range of 10^13 in mass and we address it by combining N-body simulations of structure formation to identify the most massive halos at z~6 with a Monte Carlo method based on linear theory to obtain the location and formation times of the first light halos within the whole simulation box. We show that the descendants of the first ~10^6 Msun virialized halos do not, on average, end up in the most massive halos at z~6, but rather live in a large variety of environments. The oldest PopIII progenitors of the most massive halos at z~6, form instead from density peaks that are on average one and a half standard deviations more common than the first PopIII star formed in the volume occupied by one bright high-z QSO. The intermediate mass black hole seeds planted by the very first PopIII stars at z>40 can easily grow to masses m_BH>10^9.5 Msun by z=6 assuming Eddington accretion with radiative efficiency \epsilon~0.1. Quenching of the black hole accretion is therefore crucial to avoid an overabundance of supermassive black holes at lower redshift. This can be obtained if the mass accretion is limited to a fraction \eta~6*10^{-3} of the total baryon mass of the halo hosting the black hole. The resulting high end slope of the black hole mass function at z=6 is \alpha ~ -3.7, a value within the 1\sigma error bar for the bright end slope of the observed quasar luminosity function at z=6.Comment: 30 pages, 9 figures, ApJ accepte

    Renormalization of myoglobin-ligand binding energetics by quantum many-body effects

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    We carry out a first-principles atomistic study of the electronic mechanisms of ligand binding and discrimination in the myoglobin protein. Electronic correlation effects are taken into account using one of the most advanced methods currently available, namely a linear-scaling density functional theory (DFT) approach wherein the treatment of localized iron 3d electrons is further refined using dynamical mean-field theory (DMFT). This combination of methods explicitly accounts for dynamical and multi-reference quantum physics, such as valence and spin fluctuations, of the 3d electrons, whilst treating a significant proportion of the protein (more than 1000 atoms) with density functional theory. The computed electronic structure of the myoglobin complexes and the nature of the Fe-O2 bonding are validated against experimental spectroscopic observables. We elucidate and solve a long standing problem related to the quantum-mechanical description of the respiration process, namely that DFT calculations predict a strong imbalance between O2 and CO binding, favoring the latter to an unphysically large extent. We show that the explicit inclusion of many body-effects induced by the Hund's coupling mechanism results in the correct prediction of similar binding energies for oxy- and carbonmonoxymyoglobin.Comment: 7 pages, 5 figures. Accepted for publication in the Proceedings of the National Academy of Sciences of the United States of America (2014). For the published article see http://www.pnas.org/content/early/2014/04/09/1322966111.abstrac

    Physical Bias of Galaxies From Large-Scale Hydrodynamic Simulations

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    We analyze a new large-scale (100h−1100h^{-1}Mpc) numerical hydrodynamic simulation of the popular Λ\LambdaCDM cosmological model, including in our treatment dark matter, gas and star-formation, on the basis of standard physical processes. The method, applied with a numerical resolution of <200h−1<200h^{-1}kpc (which is still quite coarse for following individual galaxies, especially in dense regions), attempts to estimate where and when galaxies form. We then compare the smoothed galaxy distribution with the smoothed mass distribution to determine the "bias" defined as b≡(δM/M)gal/(δM/M)totalb\equiv (\delta M/M)_{gal}/(\delta M/M)_{total} on scales large compared with the code numerical resolution (on the basis of resolution tests given in the appendix of this paper). We find that (holding all variables constant except the quoted one) bias increases with decreasing scale, with increasing galactic age or metallicity and with increasing redshift of observations. At the 8h−18h^{-1}Mpc fiducial comoving scale bias (for bright regions) is 1.35 at z=0z=0 reaching to 3.6 at z=3z=3, both numbers being consistent with extant observations. We also find that (10−20)h−1(10-20)h^{-1}Mpc voids in the distribution of luminous objects are as observed (i.e., observed voids are not an argument against CDM-like models) and finally that the younger systems should show a colder Hubble flow than do the early type galaxies (a testable proposition). Surprisingly, little evolution is found in the amplitude of the smoothed galaxy-galaxy correlation function (as a function of {\it comoving} separation). Testing this prediction vs observations will allow a comparison between this work and that of Kauffmann et al which is based on a different physical modelingmethod.Comment: in press, ApJ, 26 latex pages plus 7 fig

    System and method for moving a probe to follow movements of tissue

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    An apparatus is described for moving a probe that engages moving living tissue such as a heart or an artery that is penetrated by the probe, which moves the probe in synchronism with the tissue to maintain the probe at a constant location with respect to the tissue. The apparatus includes a servo positioner which moves a servo member to maintain a constant distance from a sensed object while applying very little force to the sensed object, and a follower having a stirrup at one end resting on a surface of the living tissue and another end carrying a sensed object adjacent to the servo member. A probe holder has one end mounted on the servo member and another end which holds the probe

    Beyond capitalism and liberal democracy: on the relevance of GDH Cole’s sociological critique and alternative

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    This article argues for a return to the social thought of the often ignored early 20th-century English thinker GDH Cole. The authors contend that Cole combined a sociological critique of capitalism and liberal democracy with a well-developed alternative in his work on guild socialism bearing particular relevance to advanced capitalist societies. Both of these, with their focus on the limitations on ‘free communal service’ in associations and the inability of capitalism to yield emancipation in either production or consumption, are relevant to social theorists looking to understand, critique and contribute to the subversion of neoliberalism. Therefore, the authors suggest that Cole’s associational sociology, and the invitation it provides to think of formations beyond capitalism and liberal democracy, is a timely and valuable resource which should be returned to
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