131,468 research outputs found

    Correction to: Fire spalling sensitivity of high-performance concrete in heated slabs under biaxial compressive loading

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    The article ''Fire spalling sensitivity of high-performance concrete in heated slabs under biaxial compressive loading'', written by "Francesco Lo Monte, Roberto Felicetti, Chiara Rossino", was originally published electronically on the publisher's Internet portal (currently SpringerLink) on 25 January 2019 without open access

    Candida auris Candidemia in Critically Ill, Colonized Patients: Cumulative Incidence and Risk Factors

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    open19Introduction: Candida auris (C. auris) is an emerging nosocomial pathogen, and a sharp rise in cases of colonization and infection has been registered in intensive care units (ICUs) during the ongoing coronavirus disease 2019 (COVID-19) pandemic. The unfavorable resistance profile of C. auris and the potential high mortality of C. auris infections represent an important challenge for physicians. Methods: We conducted a single-center retrospective study including all patients admitted to ICUs with isolation of C. auris in any non-sterile body site between February 20, 2020, and May 31, 2021. The primary aim of the study was to assess the cumulative incidence of C. auris candidemia in colonized patients. The secondary aim was to identify predictors of C. auris candidemia in the study population. Results: During the study period, 157 patients admitted to ICUs in our hospital became colonized with C. auris; 59% of them were affected by COVID-19. Overall, 27 patients (17%) developed C. auris candidemia. The cumulative risk of developing C. auris candidemia was > 25% at 60 days after first detection of C. auris colonization. Seven patients with C. auris candidemia (26%) also developed a late recurrent episode. All C. auris blood isolates during the first occurring episode were resistant to fluconazole and susceptible to echinocandins, while 15 (56%) were resistant to amphotericin B. During late recurrent episodes, emergent resistance to caspofungin and amphotericin B occurred in one case each. In the final multivariable model, only multisite colonization retained an independent association with the development of C. auris candidemia. Conclusion: Candida auris candidemia may occur in up to one fourth of colonized critically ill patients, and multisite colonization is an independent risk factor for the development of candidemia. Implementing adequate infection control measures remains crucial to prevent colonization with C. auris and indirectly the subsequent development of infection.openBriano, Federica; Magnasco, Laura; Sepulcri, Chiara; Dettori, Silvia; Dentone, Chiara; Mikulska, Malgorzata; Ball, Lorenzo; Vena, Antonio; Robba, Chiara; Patroniti, Nicolò; Brunetti, Iole; Gratarola, Angelo; D'Angelo, Raffaele; Di Pilato, Vincenzo; Coppo, Erika; Marchese, Anna; Pelosi, Paolo; Giacobbe, Daniele Roberto; Bassetti, MatteoBriano, Federica; Magnasco, Laura; Sepulcri, Chiara; Dettori, Silvia; Dentone, Chiara; Mikulska, Malgorzata; Ball, Lorenzo; Vena, Antonio; Robba, Chiara; Patroniti, Nicolò; Brunetti, Iole; Gratarola, Angelo; D'Angelo, Raffaele; Di Pilato, Vincenzo; Coppo, Erika; Marchese, Anna; Pelosi, Paolo; Giacobbe, Daniele Roberto; Bassetti, Matte

    Development of a Degradation Model for the Collapse Analysis of Composite Aerospace Structures

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    For stiffened structures in compression the most critical damage mechanism leading to structural collapse is delamination or adhesive disbonding between the skin and stiffener. This paper presents the development of a numerical approach capable of simulating interlaminar crack growth in composite structures as a representation of this damage mecha-nism. A degradation methodology was proposed using shell layers connected at the nodes by user-defined multiple point constraints (MPCs), and then controlling the properties of these MPCs to simulate the initiation and propagation of delamination and disbonding. A fracture mechanics approach based on the Virtual Crack Closure Technique (VCCT) is used to detect growth at the delamination front. Numerical predictions using the degradation methodology were compared to experimental results for double cantilever beam (DCB) specimens to dem-onstrate the effectiveness of the current approach. Future development will focus on address-ing the apparent conservatism of the VCCT approach, and extending the application of the method to other specimen types and stiffened structures representative of composite fuselage designs. This work is part of the European Commission Project COCOMAT (Improved MA-Terial Exploitation at Safe Design of COmposite Airframe Structures by Accurate Simulation of COllapse), an ongoing four-year project that aims to exploit the large strength reserves of composite aerospace structures through more accurate prediction of collapse

    Charged Particle Multiplicity and Pseudorapidity Density Measurements in pp collisions with ALICE at the LHC

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    These proceedings describe the charged-particle pseudorapidity densities and multiplicity distributions measured by the ALICE detector in pp collisions at s=0.9\sqrt{s} = 0.9 and 7 TeV in specific phase space regions. The pseudorapidity range ∣η∣<0.8|\eta| < 0.8, together with pTp_{\rm T} cuts at 0.15, 0.5 and 1 GeV/cc is considered. The classes of events considered are those having at least one charged particle in the kinematical ranges just described. The results obtained by ALICE are compared to Monte Carlo predictions.Comment: Proceedings for EPS-HEP Conference held in Stockholm, Sweden, 18-24 July 201

    A dam-break flood simulation model in curvilinear coordinates

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    A dam-break flood model based on a contravariant integral form of the shallow water equations is presented. The numerical integration of the equations of motion is carried out by means of a finite volumefinite difference numerical scheme that involves an exact Riemann solver and which is based on a high-order WENO reconstruction procedure. An original scheme for the simulation of the wet front progress on the dry bed is adopted. The proposed model capacity to correctly simulate the wet front progress velocity is tested by numerically reproducing the dry bed dam-break problem. The model is adopted for the real case study of the Rio Fucino lake-dam collapse and subsequent flood wave propagation, downstream of the Campotosto reservoir (Italy)

    Rigidity of Poisson Lie group actions

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    n this paper we prove that close infinitesimal momentum maps associated to Poisson Lie actions are equivalent under some mild assumptions. We also obtain rigidity theorems for actual momentum maps (when the acting Lie group G is endowed with an arbitrary Poisson structure) combining a rigidity result for canonical Hamiltonian actions (\cite{MMZ}) and a linearization theorem(\cite{GW}). These results have applications to quantization of symmetries since these infinitesimal momentum maps appear as the classical limit of quantum momentum maps (\cite{BEN}).Peer ReviewedPreprin

    The classical roots of Toland's thought

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    A Fibonacci control system with application to hyper-redundant manipulators

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    We study a robot snake model based on a discrete linear control system involving Fibonacci sequence and closely related to the theory of expansions in non-integer bases. The present paper includes an investigation of the reachable workspace, a more general analysis of the control system underlying the model, its reachability and local controllability properties and the relation with expansions in non-integer bases and with iterated function systems
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