6,630 research outputs found

    Amantadine minimally improves arousal in patients with severe traumatic brain injury

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    A critical appraisal and clinical application of Giacino JT, Whyte J, Bagiella E, et al. Placebo-Controlled Trial of Amantadine for Severe Traumatic Brain Injury. New England Journal of Medicine. 2012;366(9):819-826. doi: 10.1056/nejmoa1102609

    Behavioral Recovery and Early Decision Making in Patients with Prolonged Disturbance in Consciousness after Traumatic Brain Injury

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    The extent of behavioral recovery that occurs in patients with traumatic disorders of consciousness (DoC) following discharge from the acute care setting has been under-studied and increases the risk of overly pessimistic outcome prediction. The aim of this observational cohort study was to systematically track behavioral and functional recovery in patients with prolonged traumatic DoC following discharge from the acute care setting. Standardized behavioral data were acquired from 95 patients in a minimally conscious (MCS) or vegetative state (VS) recruited from 11 clinic sites and randomly assigned to the placebo arm of a previously completed prospective clinical trial. Patients were followed for 6 weeks by blinded observers to determine frequency of recovery of six target behaviors associated with functional status. The Coma Recovery Scale-Revised and Disability Rating Scale were used to track reemergence of target behaviors and assess degree of functional disability, respectively. Twenty percent (95% confidence interval [CI]: 13-30%) of participants (mean age 37.2; median 47 days post-injury; 69 men) recovered all six target behaviors within the 6 week observation period. The odds of recovering a specific target behavior were 3.2 (95% CI: 1.2-8.1) to 7.8 (95% CI: 2.7-23.0) times higher for patients in MCS than for those in VS. Patients with preserved language function ("MCS+") recovered the most behaviors (p ≤ 0.002) and had the least disability (p ≤ 0.002) at follow-up. These findings suggest that recovery of high-level behaviors underpinning functional independence is common in patients with prolonged traumatic DoC. Clinicians involved in early prognostic counseling should recognize that failure to emerge from traumatic DoC before 28 days does not necessarily portend unfavorable outcome

    The effect of a structured internship on the clinical performance of novice nurses?

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    Objective: The study examined the clinical performance differences of novices before and after a critical care internship and compare their performance attributes to a reference group comprised of experienced critical care nurses. The extant research regarding clinical internship programs has focused on retention in practice, workforce issues and competence. While studies have shown a pattern of improved retention in practice settings, they have failed to objectively measure actual clinical performance. Methods: The study design was based on pre-post comparisons of novice nurses and a reference group comprised of experienced nurses who served as a benchmark. The novice group was required to respond to patient needs in high-fidelity clinical scenarios before and after an internship. The experienced nurses attended a single testing session. Results: Findings revealed statistically significant improvement in the performance of the novice group; however, they failed to perform at the level of the experienced nurses. Conclusions: The study is the first to detail the degree to which a structured internship can facilitate changes in selected aspects of clinical performance. The study establishes the effect associated with engagement in a structured internship. While novices improve significantly, they fail to achieve the level of clinical performance seen in experienced nurses. The paper will present background information related to the established effects of internship programs, and will then present the data related to the current study. The paper will then present similarities and differences between the results of the current study, and the literatur

    The lack of design quality focus in construction: a case for examining suitable design processes

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    A large number of projects in UK construction now involve contractor-led design and are thus very different from the traditional approach which formed the basis of the original Royal Institute of British Architects (RIBA) Outline Plan of Work. Such integrated and contractor-led approaches support the reform agenda of the late 1990s that was introduced to tackle process inefficiency. However, within the design professions there has been concern that this resulted in buildings that were designed-down to a cost rather than designed-up to a value. An attempt to address this resulted in the formation of the Commission for Architecture and Built Environment (CABE) in 1999 and the launch, in 2003, of the Design Quality Indicator (DQI) which measures how well a building satisfies stakeholders. This paper presents the early phases of doctoral research which will examine the impact of integrated design management approaches upon Design Quality

    Codification challenges for data science in construction

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    New forms of data science, including machine learning and data analytics, are enabled by machine-readable informationbut are not widely deployed in construction. Aqualitative study of information flow in three projects usingBuilding Information Modelling (BIM) in the late designand construction phaseis used to identify the challenges of codification whichlimit the application of data science.Despite substantial efforts to codify information with ‘Common Data Environment(CDE)’ platforms to structure and transfer digital information within and between teams, participants work across multiple media in both structured and unstructured ways. Challenges of codification identified in this paper relate to software usage (interoperability, translation, modelling, and file-based sharing), information sharing (unstructured information, document control, workarounds, process change,and multiple CDEs), and construction process information(loss of constraints and low level of detail). This paper contributes to the current understanding of data science in construction by articulating the codification challenges and their implications for data quality dimensions,such as accuracy, completeness, accessibility, consistency, timeliness, and provenance.It concludes with practical implications for developingand using machine-readable information and directions for research to extract insight from data and support future automation

    Integration of virtual reality within the built environment curriculum

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    Virtual Reality (VR) technology is still perceived by many as being inaccessible and cost prohibitive with VR applications considered expensive to develop as well as challenging to operate. This paper reflects on current developments in VR technologies and describes an approach adopted for its phased integration into the academic curriculum of built environment students. The process and end results of implementing the integration are discussed and the paper illustrates the challenges of introducing VR, including the acceptance of the technology by academic staff and students, interest from industry, and issues pertaining to model development. It sets out to show that fairly sophisticated VR models can now be created by non-VR specialists using commercially available software and advocates that the implementation of VR will increase alongside industryis adoption of these tools and the emergence of a new generation of students with VR skills. The study shows that current VR technologies, if integrated appropriately within built environment academic programmes, demonstrate clear promise to provide a foundation for more widespread collaborative working environments

    The validity of capillary blood sampling in the determination of human growth hormone concentration during exercise in men

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    This is an open access article - Copyright © 2004 BMJ Publishing Group LtdBACKGROUND: Studies measuring human growth hormone (hGH) in blood during exercise have mainly used venous sampling. The invasive nature of this procedure makes evaluation of hGH impossible in various exercise environments. OBJECTIVE: To determine whether capillary sampling could offer an alternative sampling method. METHODS: Capillary and venous blood samples were collected for determination of hGH at the end of each exercise stage during an incremental exercise test in 16 male club level competitive cyclists (mean (SD) age 30.8 (8.0) years, body mass 72.2 (7.1) kg, body fat 12.9 (3.5)%, peak oxygen consumption 4.18 (0.46) l⋅min−1). Linear regression, from a plot of venous v capillary blood hGH concentration, showed a correlation coefficient of r = 0.986 (p<0.001). When geometric means and log transformations were used, a coefficient of variation of 14.2% was demonstrated between venous and capillary flow for hGH concentration. The mean ratio limits of agreement were 0.62 (1.72)—that is, 95% of the ratios were contained between 0.36 and 1.07, with a mean of 0.62. CONCLUSIONS: Capillary blood sampling is an acceptable alternative to venous sampling for determining hGH concentration during rest and exercise. Sample sites should not be used interchangeably: one site should be chosen and its use standardised

    The development of a framework for a design for safety BIM tool

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