Polarized Spectroscopy Studies of Single Molecules of Porphycenes

Using ambient atmosphere instead of pure nitrogen environment enabled efficient recording of room temperature fluorescence from single molecules of porphycenes, chromophores with a high triplet formation efficiency. Double hydrogen transfer between two chemically identical trans tautomers has been demonstrated for parent porphycene and three alkyl derivatives by the analysis of spatial patterns of the emission obtained after raster scanning the sample excited with an appropriately polarized laser beam. Because of tautomerization, fluorescence in porphycenes is due to two nearly orthogonal transition dipole moments. This property allows the spatial orientation of the single molecule chromophores to be determined using radially and azimuthally polarized laser beams as excitation sources

Printable Nanoscopic Metamaterial Absorbers and Images with Diffraction-Limited Resolution

The fabrication of functional metamaterials with extreme feature resolution finds a host of applications such as the broad area of surface/light interaction. Non-planar features of such structures can significantly enhance their performance and tunability, but their facile generation remains a challenge. Here, we show that carefully designed out-of-plane nanopillars made of metal-dielectric composites integrated in a metal-dielectric-nanocomposite configuration, can absorb broadband light very effectively. We further demonstrate that electrohydrodynamic printing in a rapid nanodripping mode, is able to generate precise out-of-plane forests of such composite nanopillars with deposition resolutions at the diffraction limit on flat and non-flat substrates. The nanocomposite nature of the printed material allows the fine-tuning of the overall visible light absorption from complete absorption to complete reflection by simply tuning the pillar height. Almost perfect absorption (~95%) over the entire visible spectrum is achieved by a nanopillar forest covering only 6% of the printed area. Adjusting the height of individual pillar groups by design, we demonstrate on-demand control of the gray scale of a micrograph with a spatial resolution of 400 nm. These results constitute a significant step forward in ultra-high resolution facile fabrication of out-of-plane nanostructures, important to a broad palette of light design applications. nanostructures, important to a broad palette of light design applications

13C NMR study of the effect of aerobic treatment of olive mill wastewater (OMW) on its lipid-free content

Olive mill wastewater was treated by an aerobic bio-process at different values of pH (with or without addition of lime), for 45 days on a laboratory scale, to evaluate the reduction of the organic load. The lipid content showed an appreciable change in relation to the applied treatment both for total lipids and for the different fractions (neutral lipids, monoglycerides and phospholipids). 13C NMR spectroscopy was performed on initial and final samples both raw and after lipid extraction. The main spectral differences were observed in the C-alkyl region (0–50 ppm), in the C O-alkyl/N-alkyl region (50–110 ppm), and in the C-carboxylic (160–200 ppm) region, providing information on the alterations occurring in the different biochemical entities composing this complex biomatrix (e.g. lipids and carbohydrates) according to the treatment

Spectroscopic studies of fluorescent perylene dyes

The lowest electronic transition of the fluorescent perylene dye bis-(3,5-di-tertbutylphenyl)-perylene-3, 4:9,10-biscarboximide has been investigated

α-Hexylcinnamaldehyde synergistically increases doxorubicin cytotoxicity towards human cancer cell lines

α-Hexylcinnamaldehyde (HCA), a compound derived from cinnamaldehyde, was evaluated for its potential chemosensitizing properties

Synthesis of ellagic acid and its 4,4'-di-Ο-alky derivatives from gallic acid

Synthesis of ellagic acid and its 4,4'-di-Ο-alkyl derivatives from gallic acid is described. Ellagic acid is prepared by oxidative coupling of gallic acid with ο-chloranil. Functionalized methyl bormogallate underwent Ullmann coupling to give the biphenyl that upon lactonization resulted in the ellagic acid and its alkoxy derivatives

Oxidative alkylation of (η5-C5Me5)2TiR (R = Cl, Me, Et, CH=CH2, Ph, OMe, N=C(H)tBu) to (η5-C5Me5)2Ti(Me)R by group 12 organometallic compounds MMe2

Oxidative alkylation of Cp*2TiX (Cp*: η5-C5Me5; X = OMe, Cl, N=C(H)tBu) and Cp* 2TiMe by CdMe2 or ZnMe2 gives diamagnetic Cp*2Ti(Me)X and Cp*2TiMe2 respectively, and cadmium or zinc. The reactions of Cp*2TiR (R = Et, CH=CH2, Ph) with MMe2 (M = Cd, Zn) give statistical mixtures of Cp*2Ti(Me)R, Cp*2TiMe2 and Cp*2TiR2. Dimethylmercury does not react with Cp*2TiX.

Creating an Antibacterial with in Vivo Efficacy: Synthesis and Characterization of Potent Inhibitors of the Bacterial Cell Division Protein FtsZ with Improved Pharmaceutical Properties

3-Methoxybenzamide (1) is a weak inhibitor of the essential bacterial cell division protein FtsZ. Alkyl derivatives of 1 are potent antistaphylococcal compounds with suboptimal drug-like properties. Exploration of the structure-activity relationships of analogues of these inhibitors led to the identification of potent antistaphylococcal compounds with improved pharmaceutical properties

Synthesis of New Analogues of the Bengamides: Peptidyl Bengamides and Molecular Probes

Isolated from sponges of the Jaspidae family, first members where discovered in 1986. The bengamides represent an interesting and unprecedented family of natural products that displayed striking antitumor activities [1]. The recognition of these natural products as antiangiogenic compounds, in virtue to their inhibition of methionine aminopeptidases, prompted intense research activities in the chemical and biological fields. In fact, the total synthesis of the natural products, together with an extensive variety of analogues, has been reported in the literature [2]. Particularly, we have recently developed a new synthetic methodology which allowed rapid and efficient access to the natural bengamide E (1), together with a wide library of analogues of which the cyclopentyl analogue 2 was identified as a more potent antitumor compound with respect to its natural congener [3]. As continuation of these synthetic efforts, with the objective of identifying new potent and promising analogues, we wish to report our recent synthetic studies directed to the synthesis of new bengamide analogues, featured by the replacement of the caprolactam fragment by a peptidyl residue (compounds type 3). On the other hand, in order to gain insight into the mechanism of the biological action of the bengamides, we describe the preparation of the N-alkyl derivatives 4 and 5, which represent interesting molecules that could be employed as suitable molecular probes.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech