19 research outputs found

    Symbolic Computations based on Grid Services

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    The widespread adoption of the current Grid technologies is still impeded by a number of problems, one of which is difficulty of developing and implementing Grid-enabled applications. In another dimension, symbolic computation, aiming to automatize the steps of mathematical problem solving, has become in the last years a basis for advanced applications in many areas of computer science. In this context we have recently analyzed and developed grid-extensions of known tools for symbolic computations. We further present in this paper a case study of a Web service-based Grid application for symbolic computations

    State-space realization of nonlinear control systems: unification and extension via pseudo-linear algebra

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    summary:In this paper the tools of pseudo-linear algebra are applied to the realization problem, allowing to unify the study of the continuous- and discrete-time nonlinear control systems under a single algebraic framework. The realization of nonlinear input-output equation, defined in terms of the pseudo-linear operator, in the classical state-space form is addressed by the polynomial approach in which the system is described by two polynomials from the non-commutative ring of skew polynomials. This allows to simplify the existing step-by-step algorithm-based solution. The paper presents explicit formulas to compute the differentials of the state coordinates directly from the polynomial description of the nonlinear system. The method is straight-forward and better suited for implementation in different computer algebra packages such as \textit{Mathematica} or \textit{Maple}

    Mathematical surfaces models between art and reality

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    In this paper, I want to document the history of the mathematical surfaces models used for the didactics of pure and applied “High Mathematics” and as art pieces. These models were built between the second half of nineteenth century and the 1930s. I want here also to underline several important links that put in correspondence conception and construction of models with scholars, cultural institutes, specific views of research and didactical studies in mathematical sciences and with the world of the figurative arts furthermore. At the same time the singular beauty of form and colour which the models possessed, aroused the admiration of those entirely ignorant of their mathematical attraction

    Design of novel drug delivery system and optimal dosage regimens

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    Three representative drug delivery systems were analyzed to emphasize the roles of mathematical models and computer-aided simulations in pharmaceutical research. In the first project, a protocol was developed so that the optimal regimen, consisting of the intravenous boluses and subsequent infusion of theophylline, could be obtained once information on the pharmacokinetics became available. The method was based on a two-compartment model of the human body. A module was created and posted on a website for free access. The second project dealt with the transdermal heat-assisted delivery of corticosterone. Heat conduction and drug diffusion through the patch and the skin were expressed in the mathematical model. Four design parameters were estimated. This model was validated using clinical data from the administration of fentanyl. Cortisone concentrations through the patch and skin layers were predicted. The results were used to rank the relative impacts of the design parameters on the corticosterone delivery and to make proper suggestions for fabricating the products. Finally, the simultaneous application of an electric current and soluble microneedles were proposed for the first time. Preliminary experimental studies suggested that the electric field enhanced the flux by increasing drug diffusion and, thereby, the dissolution of the microneedles. One-, two- and three-dimensional simulations were conducted. In addition, protocols were proposed to help with the analysis of laboratory data

    SCIENAR Virtual Community: A Useful Tool to Promote the Synergies Among Artists and Scientists

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    This paper describes a Virtual Community (VC) developed within the framework of the European project SCIENAR (Scientific Scenarios and Art). The SCIENAR project explores the connections between Art and Science and the use of new media and Information Communication Technologies (ICTs) for the exploration and representation of these relationships in an innovative and productive way. The main objective of the Virtual Community described herein is to strengthen the role of the "artistic-scientific" community in the production of new science and new art. This objective can be achieved by promoting synergies and collaborations between the different protagonists involved in the large field of research of Art and Science

    A general and age-dependent physiological based pharmacokinetic (PBPK) model development

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    Proceedings of the 12th International Conference on Technology in Mathematics Teaching ICTMT 12

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    Innovation, inclusion, sharing and diversity are some of the words that briefly and suitably characterize the ICTMT series of biennial international conferences – the International Conference on Technology in Mathematics Teaching. Being the twelfth of a series which began in Birmingham, UK, in 1993, under the influential enterprise of Professor Bert Waits from Ohio State University, this conference was held in Portugal for the first time. The 12th International Conference on Technology in Mathematics Teaching was hosted by the Faculty of Sciences and Technology of the University of Algarve, in the city of Faro, from 24 to 27 June 2015, and was guided by the original spirit of its foundation. The integration of digital technologies in mathematics education across school levels and countries, from primary to tertiary education, together with the understanding of the phenomena involved in the teaching and learning of mathematics in technological environments have always been driving forces in the transformation of pedagogical practices. The possibility of joining at an international conference a wide diversity of participants, including school mathematics teachers, lecturers, mathematicians, mathematics educators and researchers, software designers, and curriculum developers, is one facet that makes this conference rather unique. At the same time, it seeks to foster the sharing of ideas, experiences, projects and studies while providing opportunities to try-out and assess tools or didactical proposals during times of hands-on work. The ICTMT 12 had this same ambition, when embracing and welcoming just over 120 delegates who actively and enthusiastically contributed to a very packed program of scientific proposals and sessions on various topics

    Raising public awareness of mathematics

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    This book arose from the presentations given at the international workshop held in Óbidos, 26–29 September 2010, as a result of a joint initiative of the Centro Internacional de Matemática and the Raising Public Awareness (RPA) committee of the European Mathematical Society (EMS). The objective was to provide a forum for general reflection with an international mix of experts on building the image of mathematics, ten years after the World Mathematical Year 2000 (WMY 2000). Óbidos, a charming town situated one hour by car to the north of Lisbon, Portugal, was also the site of the re-creation in the year 2000 of the international mathematics exhibition “Beyond the Third Dimension” (http://alem3d.obidos.org/en/) and a meeting of the EMS WMY2000 Committee. The opening of the workshop was also a public “mathematical afternoon” organised by the Portuguese Mathematical Society (SPM) in cooperation with the town of Óbidos. At this event mathematical films and lectures to the general public were presented. The first lecture was given by H. Leitão, from the University of Lisbon, on mathematics in the “Age of Discoveries”, and the second one by G.-M. Greuel, the current president of ERCOM (the EMS committee of the European Research Centres on Mathematics), on the topic “Mathematics between Research, Application and Communication”, which text is included in this book.info:eu-repo/semantics/publishedVersio
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