11,591 research outputs found
A conceptual approach to gene expression analysis enhanced by visual analytics
The analysis of gene expression data is a complex task for biologists wishing to understand the role of genes in the formation of diseases such as cancer. Biologists need greater support when trying to discover, and comprehend, new relationships within their data. In this paper, we describe an approach to the analysis of gene expression data where overlapping groupings are generated by Formal Concept Analysis and interactively analyzed in a tool called CUBIST. The CUBIST workflow involves querying a semantic database and converting the result into a formal context, which can be simplified to make it manageable, before it is visualized as a concept lattice and associated charts
Visualizing dimensionality reduction of systems biology data
One of the challenges in analyzing high-dimensional expression data is the
detection of important biological signals. A common approach is to apply a
dimension reduction method, such as principal component analysis. Typically,
after application of such a method the data is projected and visualized in the
new coordinate system, using scatter plots or profile plots. These methods
provide good results if the data have certain properties which become visible
in the new coordinate system and which were hard to detect in the original
coordinate system. Often however, the application of only one method does not
suffice to capture all important signals. Therefore several methods addressing
different aspects of the data need to be applied. We have developed a framework
for linear and non-linear dimension reduction methods within our visual
analytics pipeline SpRay. This includes measures that assist the interpretation
of the factorization result. Different visualizations of these measures can be
combined with functional annotations that support the interpretation of the
results. We show an application to high-resolution time series microarray data
in the antibiotic-producing organism Streptomyces coelicolor as well as to
microarray data measuring expression of cells with normal karyotype and cells
with trisomies of human chromosomes 13 and 21
Approximated and User Steerable tSNE for Progressive Visual Analytics
Progressive Visual Analytics aims at improving the interactivity in existing
analytics techniques by means of visualization as well as interaction with
intermediate results. One key method for data analysis is dimensionality
reduction, for example, to produce 2D embeddings that can be visualized and
analyzed efficiently. t-Distributed Stochastic Neighbor Embedding (tSNE) is a
well-suited technique for the visualization of several high-dimensional data.
tSNE can create meaningful intermediate results but suffers from a slow
initialization that constrains its application in Progressive Visual Analytics.
We introduce a controllable tSNE approximation (A-tSNE), which trades off speed
and accuracy, to enable interactive data exploration. We offer real-time
visualization techniques, including a density-based solution and a Magic Lens
to inspect the degree of approximation. With this feedback, the user can decide
on local refinements and steer the approximation level during the analysis. We
demonstrate our technique with several datasets, in a real-world research
scenario and for the real-time analysis of high-dimensional streams to
illustrate its effectiveness for interactive data analysis
You can't always sketch what you want: Understanding Sensemaking in Visual Query Systems
Visual query systems (VQSs) empower users to interactively search for line
charts with desired visual patterns, typically specified using intuitive
sketch-based interfaces. Despite decades of past work on VQSs, these efforts
have not translated to adoption in practice, possibly because VQSs are largely
evaluated in unrealistic lab-based settings. To remedy this gap in adoption, we
collaborated with experts from three diverse domains---astronomy, genetics, and
material science---via a year-long user-centered design process to develop a
VQS that supports their workflow and analytical needs, and evaluate how VQSs
can be used in practice. Our study results reveal that ad-hoc sketch-only
querying is not as commonly used as prior work suggests, since analysts are
often unable to precisely express their patterns of interest. In addition, we
characterize three essential sensemaking processes supported by our enhanced
VQS. We discover that participants employ all three processes, but in different
proportions, depending on the analytical needs in each domain. Our findings
suggest that all three sensemaking processes must be integrated in order to
make future VQSs useful for a wide range of analytical inquiries.Comment: Accepted for presentation at IEEE VAST 2019, to be held October 20-25
in Vancouver, Canada. Paper will also be published in a special issue of IEEE
Transactions on Visualization and Computer Graphics (TVCG) IEEE VIS
(InfoVis/VAST/SciVis) 2019 ACM 2012 CCS - Human-centered computing,
Visualization, Visualization design and evaluation method
Interactive data exploration with targeted projection pursuit
Data exploration is a vital, but little considered, part of the scientific process; but few visualisation tools can cope with truly complex data. Targeted Projection Pursuit (TPP) is an interactive data exploration technique that provides an intuitive and transparent interface for data exploration. A prototype has been evaluated quantitatively and found to outperform algorithmic techniques on standard visual analysis tasks
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