Classification Algorithms of Maternal Risk Detection For Preeclampsia With Hypertension During Pregnancy Using Particle Swarm Optimization

Preeclampsia is a pregnancy abnormality that develops after 20 weeks of pregnancy characterized by hypertension and proteinuria.  The purpose of this research was to predict the risk of preeclampsia level in pregnant women during pregnancy process using Neural Network and Deep Learning algorithm, and compare the result of both algorithm. There are 17 parameters that taken from 1077 patient data in Haji General Hospital Surabaya and two hospitals in Makassar start on December 12th 2017 until February 12th 2018. We use particle swarm optimization (PSO) as the feature selection algorithm. This experiment shows that PSO can reduce the number of attributes from 17 to 7 attributes. Using LOO validation on the original data show that the result of Deep Learning has the accuracy of 95.12% and it give faster execution time by using the reduced dataset (eight-speed quicker than the original data performance). Beside that the accuracy of Deep Learning increased 0.56% become 95.68%. Generally, PSO gave the excellent result in the significantly lowering sum attribute as long as keep and improve method and precision although lowering computational period. Deep Learning enables end-to-end framework, and only need input and output without require for tweaking the attributes or features and does not require a long time and complex systems and understanding of the deep data on computing

Intimate Partner Violence And 30-Year Cardiovascular Disease Risk Among Young Adult Women In The United States

Intimate partner violence (IPV), the physical, sexual, psychological abuse or control by a former or current intimate partner, affects almost one-third of women in the United States. IPV exposure can result in many negative outcomes including physical injury, increased stress, and depression. Currently, there is a growing body of literature examining the link between IPV victimization and poor heart health. However, there is little known on how IPV impacts cardiovascular disease (CVD) risk among young adult women and what outcomes associated with IPV victimization may be increasing this risk. Using a physiologic framework and a stress and coping framework, a secondary analysis of the National Longitudinal Study of Adolescent to Adult Health (Add Health) was conducted to examine the association between past year IPV exposure and 30-year CVD risk score among a representative sample of young adult women in the United States. Regression analyses were run to examine the relationship between IPV and 30-year CVD risk score. Multiple mediation analyses were run to examine possible mediating factors in the relationship between IPV and CVD risk including perceived stress, depressive symptoms, alcohol dependence, and high sensitivity C-reactive protein levels. The results of the bivariate analyses suggested that past year IPV exposure may have a small impact on 30-year risk score, however this finding becomes insignificant when important covariates are introduced into the model highlighting the complexity of IPV and its co-occurring phenomenon. The mediation analyses revealed that perceived stress and depressive symptoms were partial independent mediators of the relationship between IPV and 30-year CVD risk score. In a multiple mediation model, the indirect effect of perceived stress became insignificant when depressive symptoms were introduced. The findings of this study reveal that 30-year CVD risk in the context of IPV victimization should continue to be examined among this population. The mediation models suggested the importance of stress and depression in the context of IPV and heart health. Screening for depression among women exposed to IPV should be considered as an important intervention point, not only to mitigate mental health issues, but to also help prevent the development of cardiovascular disease

The Effect of Compulsory Schooling on Health - Evidence from Biomarkers

Using data from the Health Survey for England and the English Longitudinal Study on Ageing, we estimate the causal effect of schooling on health. Identification comes from two nation wide increases in British compulsory school leaving age in 1947 and 1973, respectively. Our study complements earlier studies exploiting compulsory schooling laws as source of exogenous variation in schooling by using biomarkers as measures of health outcomes in addition to self-reported measures. We find a strong positive correlation between education and health, both self-rated and measured by blood fibrinogen and C-reactive protein levels. However, we find ambiguous causal effects of schooling on women's self-rated health and insignificant causal effects of schooling on men's self-rated health and biomarker levels in both sexes.health, compulsory schooling, biomarkers, regression discontinuity

Maternal ABO Blood Phenotype and Factors Associated with Preeclampsia Subtype

Preeclampsia affects 3-8% of all pregnancies and is a global issue that significantly effects the short and long-term health of women and neonates. The pathophysiology of preeclampsia remains unclear and there seems to be two distinct subtypes, early and late onset. Each subtype may have a unique pathophysiology and set of risk factors. Preeclampsia is linked to long-term risk of cardiovascular disease in previously affected women. Subsequently, risk factors shared between preeclampsia and cardiovascular disease should be explored. The main aim of this study was to determine the strength of association between maternal ABO blood type and preeclampsia subtype. This hospital-based case control study was completed at one community hospital in the Mid Atlantic, United States. The study included 126 female subjects with early onset preeclampsia (≤ 33 6/7 weeks gestation), 126 female subjects with late onset preeclampsia (≥ 34 weeks gestation) and 259 control subjects with no history of preeclampsia. Strict diagnostic criteria were used and preeclamptic subjects were classified by subtype based on gestational age at diagnosis. Data on ABO blood type, as well other physical and socio-demographic variables were extracted from the electronic health record. No significant association was noted between preeclampsia subtype and non-O blood type (p=.456) and ABO blood phenotype trended towards significance (p=.062). After exclusion of subjects with comorbidities (CHTN, GDM and DM) from the sample (n=403), there was a significant association noted between ABO blood type and preeclampsia subtype (p=.001). A significant association was also noted between preeclamptic subjects with growth restriction and ABO blood type (p= \u3c.001). Preeclamptic subjects with the B blood type had OR=3.44, 95% CI 1.58, 7.50 of having a growth-restricted fetus than did those with other blood types. Finally, when adjusting for race only, subjects with AB blood type had the following odds (OR=3.03, 95% CI 1.04, 8.80; OR=3.35, 95% CI 1.02, 11.03.) of developing pre-eclampsia and late onset preeclampsia respectively. When other clinical risk factors of preeclampsia are included in the model, AB blood type significantly predicts membership in the early onset preeclampsia subtype (OR=5.41, 95% CI, 1.19, 24.55) and was trend-level in the late onset group (p=.053). Preeclamptic women with B blood type had three times the odds of having a growth-restricted fetus, subsequently; they may require close ultrasound surveillance. AB blood type was significantly associated with three times increased odds of late onset preeclampsia. When included in a model with other common risk factors of preeclampsia, ABO blood type only accounted for a small amount of variability in the model. ABO blood type may not be a valuable addition to a preeclampsia-screening algorithm that already includes common clinical risk factors of preeclampsia. However, when controlling for other common clinical risk factors of preeclampsia, women with AB blood type had over 5 times the odds of developing early onset preeclampsia. Further research is necessary to examine if blood type regulates biomarkers that mediate the development of each preeclampsia subtype or in some way is associated with severe features of the disease

The effect of compulsory schooling on health - evidence from biomarkers

Using data from the Health Survey for England and the English Longitudinal Study on Ageing, we estimate the causal effect of schooling on health. Identification comes from two nation wide increases in British compulsory school leaving age in 1947 and 1973, respectively. Our study complements earlier studies exploiting compulsory schooling laws as source of exogenous variation in schooling by using biomarkers as measures of health outcomes in addition to self-reported measures. We find a strong positive correlation between education and health, both self-rated and measured by blood fibrinogen and C-reactive protein levels. However, we find ambiguous causal effects of schooling on women's self-rated health and insignificant causal effects of schooling on men's self-rated health and biomarker levels in both sexes.Health, Compulsory schooling, Biomarkers, Regression discontinuity

EVALUATING NOVEL RISK FACTOR ASSOCIATIONS FOR SUBCLINICAL CARDIOVASCULAR DISEASE

Globally, cardiovascular disease (CVD) is the leading cause of death. Increased risk for CVD can be attributed to smoking, high blood pressure, poor lipid profiles, obesity and psychosocial factors. Markers of subclinical CVD are non-invasive measures that detect early atherosclerotic changes. The purpose of this dissertation was to evaluate novel risk factor associations for subclinical CVD in three distinct populations. The protective effect of HDL-c for subclinical CVD was diminished in a population of postmenopausal women compared to premenopausal women. Furthermore, the concentration of small HDL particles was higher among postmenopausal women. Lipid profile changes with the menopausal transition may in part explain the increased risk of CVD seen after menopause.The protective effect of education for subclinical CVD was evident only among females from an Afro-Caribbean population. Educational differences in SBP and lipids varied for males and females providing insight into potential mechanisms for the education-subclinical CVD relationship observed on the island of Tobago.Tonic cardiac sympathetic activity and parasympathetic reactivity were independent predictors of subclinical CVD in a population of overweight and obese young adults. The effect of C-reactive protein (CRP) on subclinical CVD is potentially explained by the autonomic anti-inflammatory mechanisms linking heart rate variability and CRP. Identifying novel risk factor associations for subclinical CVD in various populations supports the important public health objective of reducing the global burden of CVD morbidity and mortality through early detection of atherosclerosis

Informed Decision Making During Pregnancy: Risk Consideration in Clinical Practice and Research

This thesis addressed a cluster of issues related to risk and the pregnant woman’s decision making in clinical practice and research. In terms of clinical practice, the minimal risk concept - a low risk standard codified in research ethics regulations - was applied to clinicians’ information provision to the patient. As clinicians must discuss a variety of health risks, minimal risk standards may be useful as a threshold to demarcate risks that clinicians should discuss with the patient. Application of minimal risk standards to risk factors in pregnancy showed the usefulness and limitations of these standards. In terms of pregnant women’s clinical research participation, analyses of national and international research ethics regulations suggested that regulations could potentially be overprotective. A grounded theory study revealed that pregnant women were protective of themselves and their fetus in considering clinical research participation. In determining whether a clinical research project involving pregnant women would be acceptable, obstetric healthcare providers emphasized the adherence to regulatory requirements while researchers in reproduction areas focused on scrutinizing the scientific quality and interpretation of prerequisite studies. These three populations shared safety concerns. While minimal risk standards may be useful in identifying risks to be discussed with the patient, determining permissible risk during pregnancy may be more complex, including consideration on the risk benefit ratio in the pregnant woman’s context. This thesis has implications on risk communication in clinical practice and research, policies on clinical research with pregnant women, and education for healthcare providers, clinical investigators, and the general public

Predictors and methological issues in tracking total body fat mass, trunk fat, mass and abdominal fat mass : changes in a weight loss intervention with overweight and obese women.

Doutoramento em Motricidade Humana, especialidade de Saúde e Condição FísicaOne of the purposes of this dissertation was to analyze the usefulness of simple anthropometric measurements in predicting total body fat mass, as well as trunk and abdominal fat regions of interest, assessed by DXA, along with their changes in a weight loss program. Another purpose was to examine the influence of different physical activity dimensions on body weight, total body fat mass, abdominal and trunk fat regions of interest, selected by conventional whole body DXA in premenopausal overweight and obese women. Three studies were conducted within the PESO Program (Promotion of Exercise and Health in Obesity), a behavioural intervention addressed to premenopausal overweight and obese women. Key results show that: a) changes in lifestyle habits during a weight loss intervention may provide a stimulus to reduce trunk fat mass, with special focus on abdominal fat mass; b) abdominal circumference is a better predictor of body fat mass loss than waist circumference; c) baseline values of body weight, BMI, sagital diameter and hip circumference, are able to predict total body fat mass changes, but are unable to predict alterations in more specific depots of body fat estimated by DXA; d) alterations in DXA abdominal fat mass estimations were reasonably detected by all the anthropometric variables, but cannot be used to quantify fat mass loss; e) physical activity variables did not induce changes in total body fat mass and body weight; f) an increase in the total amount of physical activity and the increment of total minutes walking played an important role in the reduction of abdominal fat mass estimated by DXA in obese women. RESUMO: Analisar a utilidade de simples medidas antropométricas na predição da massa gorda corporal total, assim como da massa gorda do tronco e região abdominal, estimadas por uma região de interesse obtida pela DXA, bem como as suas alterações, foi um dos objectivos desta dissertação. Outro dos objectivos desta tese prendeu-se com a análise da influência de diferentes dimensões de actividade física no peso corporal, massa gorda corporal total e regiões de interesse (tronco e abdominal) estimadas pela DXA em mulheres com excesso de peso ou obesas. Três estudos foram realizados com base no Programa PESO (Promoção do Exercício e da Saúde na Obesidade), uma intervenção de modificação comportamental em mulheres com excesso de peso ou obesas. Os resultados destes estudos demonstraram que: a) as alterações no estilo de vida durante uma intervenção de perda de peso podem constituir um estímulo na redução da massa gorda do tronco, em particular da massa gorda abdominal; b) o perímetro abdominal prediz melhor a perda de massa gorda corporal total do que o perímetro da cintura; c) os valores iniciais do peso corporal, IMC, diâmetro sagital e perímetro da anca, são bons predictores das alterações da massa gorda corporal total, mas são ineficazes na predição das alterações dos depósitos mais específicos estimados pela DXA; d) as alterações na estimação da massa gorda abdominal obtida pela DXA foram razoavelmente detectadas por todas as medidas antropométricas, mas estas medidas não podem ser utilizadas na quantificação da perda de massa gorda; e) as variáveis de actividade física não induziram alterações na massa gorda corporal total e no peso corporal; f) um incremento na quantidade total de actividade física e um incremento no número de minutos a caminhar podem ter um papel importante na redução da massa gorda abdominal estimada pela DXA em mulheres obesas

2021 - The Second Annual Fall Symposium of Student Scholars

The full program book from the Fall 2020 Symposium of Student Scholars, held on November 18, 2021. Includes abstracts from the presentations and posters.https://digitalcommons.kennesaw.edu/sssprograms/1024/thumbnail.jp