Maternal BMI as a predictor of methylation of obesity-related genes in saliva samples from preschool-age Hispanic children at-risk for obesity.

BackgroundThe study of epigenetic processes and mechanisms present a dynamic approach to assess complex individual variation in obesity susceptibility. However, few studies have examined epigenetic patterns in preschool-age children at-risk for obesity despite the relevance of this developmental stage to trajectories of weight gain. We hypothesized that salivary DNA methylation patterns of key obesogenic genes in Hispanic children would 1) correlate with maternal BMI and 2) allow for identification of pathways associated with children at-risk for obesity.ResultsGenome-wide DNA methylation was conducted on 92 saliva samples collected from Hispanic preschool children using the Infinium Illumina HumanMethylation 450 K BeadChip (Illumina, San Diego, CA, USA), which interrogates >484,000 CpG sites associated with ~24,000 genes. The analysis was limited to 936 genes that have been associated with obesity in a prior GWAS Study. Child DNA methylation at 17 CpG sites was found to be significantly associated with maternal BMI, with increased methylation at 12 CpG sites and decreased methylation at 5 CpG sites. Pathway analysis revealed methylation at these sites related to homocysteine and methionine degradation as well as cysteine biosynthesis and circadian rhythm. Furthermore, eight of the 17 CpG sites reside in genes (FSTL1, SORCS2, NRF1, DLC1, PPARGC1B, CHN2, NXPH1) that have prior known associations with obesity, diabetes, and the insulin pathway.ConclusionsOur study confirms that saliva is a practical human tissue to obtain in community settings and in pediatric populations. These salivary findings indicate potential epigenetic differences in Hispanic preschool children at risk for pediatric obesity. Identifying early biomarkers and understanding pathways that are epigenetically regulated during this critical stage of child development may present an opportunity for prevention or early intervention for addressing childhood obesity.Trial registrationThe clinical trial protocol is available at ClinicalTrials.gov ( NCT01316653 ). Registered 3 March 2011

Risk factors associated with overweight and obesity among urban school children and adolescents in Bangladesh: a case–control study

Background Childhood obesity has become an emerging urban health problem in urban cities in Bangladesh, particularly in affluent families. Risk factors for obesity in this context have not been explored yet. The objective of this study was to identify the risk factors associated with overweight and obesity among school children and adolescents in Dhaka, Bangladesh. Methods From October through November 2007, we conducted a case–control study among children aged 10–15 years in seven schools in Dhaka. We assessed body mass index (weight in kg/height in sq. meter) to identify the cases (overweight/obese) and controls (healthy/normal weight) following the Centers for Disease Control and Prevention age and sex specific growth chart. We used a structured questionnaire to collect demographic information and respondent’s exposure to several risk factors such as daily physical activity at home and in school, hours spent on computer games and television watching, maternal education level and parents’ weight and height. Results We enrolled 198 children: 99 cases, 99 controls. Multiple logistic regression analysis revealed that having at least one overweight parent (OR = 2.8, p = 0.001) and engaging in sedentary activities for >4 hours a day (OR = 2.0, p = 0.02) were independent risk factors for childhood overweight and/or obesity while exercising ≥ 30 minutes a day at home was a protective factor (OR = 0.4, p = 0.02). There were no significant associations between childhood overweight and sex, maternal education or physical activity at school. Conclusion Having overweight parents along with limited exercise and high levels of sedentary activities lead to obesity among school children in urban cities in Bangladesh. Public health programs are needed to increase awareness on risk factors for overweight and obesity among children and adolescents in order to reduce the future burden of obesity-associated chronic diseases.</p

Determinants of childhood obesity in representative sample of children in north east of iran

Childhood obesity has become, a global public health problem, and epidemiological studies are important to identify its determinants in different populations. This study aimed to investigate factors associated with obesity in a representative sample of children in Neishabour, Iran. This study was conducted among 1500 randomly selected 6-12-year-old students from urban areas of Neishabour, northeast of Iran. Then, through a case-control study, 114 obese (BMI � 95 th percentile of Iranian reference) children were selected as the case group and were compared with 102 controls (15 th � BMI 85 th percentile). Factors suggested to be associated with weight status were investigated, for example, parental obesity, child physical activity levels, socio-economic status (SES), and so forth. The analysis was conducted using univariate and multivariate logistic regression (MLR) in SPSS version 16. In univariate logistic regression model, birth weight, birth order, family extension, TV watching, sleep duration, physical activity, parents job, parents education, parental obesity history, and SES were significantly associated with childrens obesity. After MLR analysis, physical activity and parental obesity history remained statistically significant in the model. Our findings showed that physical activity and parental obesity history are the most important determinants for childhood obesity in our population. This finding should be considered in implementation of preventive interventions. Copyright © 2012 Fereshteh Baygi et al

What is the Economic Cost of Overweight Children?

Childhood overweight is now considered the most common health problem for children in the U.S. An important question is whether parents and policymakers will see rising medical expenditures for these children while they are still young. We estimate the overweight attributable fraction (OAF) of children’s medical expenditures, controlling for other factors that may cause expenditures to differ. We find that medical expenditures for overweight children are on average $12.09 higher per year (OAF = 0.5 percent), but confidence intervals are large and include zero. We also find little difference in the types of principal diagnoses per visit reported by weight status.

Computational Content Analysis of Negative Tweets for Obesity, Diet, Diabetes, and Exercise

Social media based digital epidemiology has the potential to support faster response and deeper understanding of public health related threats. This study proposes a new framework to analyze unstructured health related textual data via Twitter users' post (tweets) to characterize the negative health sentiments and non-health related concerns in relations to the corpus of negative sentiments, regarding Diet Diabetes Exercise, and Obesity (DDEO). Through the collection of 6 million Tweets for one month, this study identified the prominent topics of users as it relates to the negative sentiments. Our proposed framework uses two text mining methods, sentiment analysis and topic modeling, to discover negative topics. The negative sentiments of Twitter users support the literature narratives and the many morbidity issues that are associated with DDEO and the linkage between obesity and diabetes. The framework offers a potential method to understand the publics' opinions and sentiments regarding DDEO. More importantly, this research provides new opportunities for computational social scientists, medical experts, and public health professionals to collectively address DDEO-related issues.Comment: The 2017 Annual Meeting of the Association for Information Science and Technology (ASIST

Current and Future Medical Costs of Childhood Obesity in Alaska

This study examines the medical costs of childhood obesity in Alaska, today and in the future. We estimate that 15.2% of those ages 2 to 19 in Alaska are obese. Using parameters from published reports and studies, we estimate that the total excess medical costs due to obesity for both adults and children in Alaska in 2012 were $226 million, with medical costs of obese children and adolescents accounting for about$7 million of that total. And those medical costs will get much higher over time, as today’s children transition into adulthood. Aside from the 15.2% currently obese, another estimated 20% of children who aren’t currently obese will become obese as adults, if current national patterns continue. We estimate that the 20-year medical costs—discounted to present value—of obesity among the current cohort of Alaska children and adolescents will be $624 million in today’s dollars. But those future costs could be decreased if Alaskans found ways to reduce obesity. We consider how reducing obesity in several ways could reduce future medical costs: reducing current rates of childhood obesity, rates of obese children who become obese adults, or rates of non-obese children and adolescents who become obese adults. We undertake modest reductions to showcase the potential cost savings associated with each of these channels. Clearly the financial\ savings are a direct function of the obesity reductions and therefore the magnitude of the realized savings will vary accordingly. Also keep in mind that these figures are only for the current cohort of children and adolescents; over time more generations of Alaskans will grow from children into adults, repeating the same cycle unless rates of obesity decline. And finally, remember that medical costs are only part of the broader range of social and economic costs obesity creates.Alaska Department of Health and Social Services Section of Chronic Disease Prevention and Health Promotion Sectio

F as in Fat: How Obesity Policies Are Failing in America, 2009

Examines annual trends in national and state obesity rates, related health indicators, and policies. Discusses the economic downturn's effect on Americans' health and healthcare costs. Calls for investment in community-based disease prevention programs

F as in Fat: How Obesity Policies Are Failing in America, 2006

Examines national and state obesity rates and government policies. Offers recommendations to check the obesity crisis, including a twenty-step action plan for addressing the healthcare burdens and financial costs associated with the epidemic

An Assessment of Health-Economic Burden of Obesity Trends with Population-Based Preventive Strategies in a Developed Economy

The burden of obesity varies with age, ethnicity, socio-economic status and state economies. All new projections should hence accommodate population ageing, and other population changes such as immigration, health-care system reform, or technological advances for disease treatment for a comprehensible assessment of global burden. The unfordable and expensive nature for reversing the obesity tide arises from policies developed to combat obesity. Most of these approaches aim at bringing the problem under control, rather than affecting a cure, and obviously require a multi-disciplinary and intensive regimen. Prevention is the only feasible option and is essential for all affected countries. Yet it is not simple to have population based UK-wide strategic framework for tackling obesity. Besides existence of multiple layers of governance, there are clear demarcations between targets in diet; nutrition and physical activity level between regions some of which are not realistic. Population based approaches target policies and process, aiming for a transition towards healthy population diets, activity levels and weight status. It is essential to understand these aspects differ culturally and between and within countries. There are still no clear and appropriate answers about answer when, where, why, and, how costs accrue in obese populations, further long term commitments are required for the same. Most population-based prevention policies are cost effective, largely paying for themselves through future health gains and resulting reductions in health expenditures. Therefore these prevention programs should be high on the scientific and political agendas