Emerging technologies for the non-invasive characterization of physical-mechanical properties of tablets

The density, porosity, breaking force, viscoelastic properties, and the presence or absence of any structural defects or irregularities are important physical-mechanical quality attributes of popular solid dosage forms like tablets. The irregularities associated with these attributes may influence the drug product functionality. Thus, an accurate and efficient characterization of these properties is critical for successful development and manufacturing of a robust tablets. These properties are mainly analyzed and monitored with traditional pharmacopeial and non-pharmacopeial methods. Such methods are associated with several challenges such as lack of spatial resolution, efficiency, or sample-sparing attributes. Recent advances in technology, design, instrumentation, and software have led to the emergence of newer techniques for non-invasive characterization of physical-mechanical properties of tablets. These techniques include near infrared spectroscopy, Raman spectroscopy, X-ray microtomography, nuclear magnetic resonance (NMR) imaging, terahertz pulsed imaging, laser-induced breakdown spectroscopy, and various acoustic- and thermal-based techniques. Such state-of-the-art techniques are currently applied at various stages of development and manufacturing of tablets at industrial scale. Each technique has specific advantages or challenges with respect to operational efficiency and cost, compared to traditional analytical methods. Currently, most of these techniques are used as secondary analytical tools to support the traditional methods in characterizing or monitoring tablet quality attributes. Therefore, further development in the instrumentation and software, and studies on the applications are necessary for their adoption in routine analysis and monitoring of tablet physical-mechanical properties

Unmanned Aerial Vehicles (UAVs) in environmental biology: A Review

Acquiring information about the environment is a key step during each study in the field of environmental biology at different levels, from an individual species to community and biome. However, obtaining information about the environment is frequently difficult because of, for example, the phenological timing, spatial distribution of a species or limited accessibility of a particular area for the field survey. Moreover, remote sensing technology, which enables the observation of the Earth’s surface and is currently very common in environmental research, has many limitations such as insufficient spatial, spectral and temporal resolution and a high cost of data acquisition. Since the 1990s, researchers have been exploring the potential of different types of unmanned aerial vehicles (UAVs) for monitoring Earth’s surface. The present study reviews recent scientific literature dealing with the use of UAV in environmental biology. Amongst numerous papers, short communications and conference abstracts, we selected 110 original studies of how UAVs can be used in environmental biology and which organisms can be studied in this manner. Most of these studies concerned the use of UAV to measure the vegetation parameters such as crown height, volume, number of individuals (14 studies) and quantification of the spatio-temporal dynamics of vegetation changes (12 studies). UAVs were also frequently applied to count birds and mammals, especially those living in the water. Generally, the analytical part of the present study was divided into following sections: (1) detecting, assessing and predicting threats on vegetation, (2) measuring the biophysical parameters of vegetation, (3) quantifying the dynamics of changes in plants and habitats and (4) population and behaviour studies of animals. At the end, we also synthesised all the information showing, amongst others, the advances in environmental biology because of UAV application. Considering that 33% of studies found and included in this review were published in 2017 and 2018, it is expected that the number and variety of applications of UAVs in environmental biology will increase in the future

Coseismic surface deformation from air photos: The Kickapoo step over in the 1992 Landers rupture

Coseismic deformation of the ground can be measured from aerial views taken before and after an earthquake. We chose the area of the Kickapoo-Landers step over along the 1992 Landers earthquake zone, using air photos (scale 1:40,000) scanned at 0.4 m resolution. Two photos acquired after the earthquake are used to assess the accuracy and to evaluate various sources of noise. Optical distortions, film deformation, scanning errors, or errors in viewing parameters can yield metric bias at wavelength larger than 1 km. Offset field at shorter wavelength is more reliable and mainly affected by temporal decorrelation of the images induced by changes in radiometry with time. Temporal decorrelation and resulting uncertainty on offsets are estimated locally from the correlation degree between the images. Relative surface displacements are measured independently every about 15 m and with uncertainty typically below 10 cm (RMS). The offset field reveals most of the surface ruptures mapped in the field. The fault slip is accurate to about 7 cm (RMS) and measured independently every 200 m from stacked profiles. Slip distribution compares well with field measurements at the kilometric scale but reveals local discrepancies suggesting that deformation is generally, although not systematically, localized on the major fault zone located in the field. This type of data can provide useful insight into the fault zone's mechanical properties. Our measurements indicate that elastic coseismic strain near the fault zone can be as large as 0.5 × 10^(−3), while anelastic yielding was attained for strain in excess of about 1–2 × 10^(−3)

Monitoring the defoliation of hardwood forests in Pennsylvania using LANDSAT

An automated system for conducting annual gypsy moth defoliation surveys using LANDSAT MSS data and digital processing techniques is described. A two-step preprocessing procedure was developed that uses multitemporal data sets representing forest canopy conditions before and after defoliation to create a digital image in which all nonforest cover types are eliminated or masked out of a LANDSAT image that exhibits insect defoliation. A temporal window for defoliation assessment was identified and a statewide data base was established. A data management system to interface image analysis software with the statewide data base was developed and a cost benefit analysis of this operational system was conducted

S190 interpretation techniques development and application to New York State water resources

The author has identified the following significant results. The program has demonstrated that Skylab imagery can be utilized to regularly monitor eutrophication indices of lakes, such as chlorophyll concentration and photic zone depth. The relationship between the blue to green reflectance ratio and chlorophyll concentration was shown, along with changes in lake properties caused by chlorophyll, lignin, and humic acid using reflectance ratios and changes. A data processing technique was developed for detecting atmospheric fluctuations occurring over a large lake

Automated identification of river hydromorphological features using UAV high resolution aerial imagery

European legislation is driving the development of methods for river ecosystem protection in light of concerns over water quality and ecology. Key to their success is the accurate and rapid characterisation of physical features (i.e., hydromorphology) along the river. Image pattern recognition techniques have been successfully used for this purpose. The reliability of the methodology depends on both the quality of the aerial imagery and the pattern recognition technique used. Recent studies have proved the potential of Unmanned Aerial Vehicles (UAVs) to increase the quality of the imagery by capturing high resolution photography. Similarly, Artificial Neural Networks (ANN) have been shown to be a high precision tool for automated recognition of environmental patterns. This paper presents a UAV based framework for the identification of hydromorphological features from high resolution RGB aerial imagery using a novel classification technique based on ANNs. The framework is developed for a 1.4 km river reach along the river Dee in Wales, United Kingdom. For this purpose, a Falcon 8 octocopter was used to gather 2.5 cm resolution imagery. The results show that the accuracy of the framework is above 81%, performing particularly well at recognising vegetation. These results leverage the use of UAVs for environmental policy implementation and demonstrate the potential of ANNs and RGB imagery for high precision river monitoring and river management

Third Earth Resources Technology Satellite Symposium. Volume 3: Discipline summary reports

Presentations at the conference covered the following disciplines: (1) agriculture, forestry, and range resources; (2) land use and mapping; (3) mineral resources, geological structure, and landform surveys; (4) water resources; (5) marine resources; (6) environment surveys; and (7) interpretation techniques

Third ERTS Symposium: Abstracts

Abstracts are provided for the 112 papers presented at the Earth Resources Program Symposium held at Washington, D.C., 10-14 December, 1973