Rethinking the risk matrix

So far risk has been mostly defined as the expected value of a loss, mathematically PL (being P the probability of an adverse event and L the loss incurred as a consequence of the adverse event). The so called risk matrix follows from such definition. This definition of risk is justified in a long term “managerial” perspective, in which it is conceivable to distribute the effects of an adverse event on a large number of subjects or a large number of recurrences. In other words, this definition is mostly justified on frequentist terms. Moreover, according to this definition, in two extreme situations (high-probability/low-consequence and low-probability/high-consequence), the estimated risk is low. This logic is against the principles of sustainability and continuous improvement, which should impose instead both a continuous search for lower probabilities of adverse events (higher and higher reliability) and a continuous search for lower impact of adverse events (in accordance with the fail-safe principle). In this work a different definition of risk is proposed, which stems from the idea of safeguard: (1Risk)=(1P)(1L). According to this definition, the risk levels can be considered low only when both the probability of the adverse event and the loss are small. Such perspective, in which the calculation of safeguard is privileged to the calculation of risk, would possibly avoid exposing the Society to catastrophic consequences, sometimes due to wrong or oversimplified use of probabilistic models. Therefore, it can be seen as the citizen’s perspective to the definition of risk

Across Space and Time. Papers from the 41st Conference on Computer Applications and Quantitative Methods in Archaeology, Perth, 25-28 March 2013

This volume presents a selection of the best papers presented at the forty-first annual Conference on Computer Applications and Quantitative Methods in Archaeology. The theme for the conference was "Across Space and Time", and the papers explore a multitude of topics related to that concept, including databases, the semantic Web, geographical information systems, data collection and management, and more

Greening Cities Shaping Cities

The topic of pinpointing Nature-Based Solutions (NBS) in the urban context has been cultivating interest lately from different scholars, urban planning practitioners and policymakers. This Special Issue originates from the Greening Cities Shaping Cities Symposium held at the Politecnico di Milano (12–13 October 2020), aiming at bridging the gap between the science and practice of implementing NBS in the built environment, as well as highlighting the importance of citizen participation in shared governance and policy making. The Special Issue received contributions from all over the world, from Italy, Germany, the Netherlands, Turkey, Brazil, Portugal, Denmark, France, Bulgaria, Sweden, Hungary, Spain, the UAE, the UK, and the USA

Greening Cities Shaping Cities: Pinpointing Nature-Based Solutions in Cities between Shared Governance and Citizen Participation

The topic of pinpointing Nature-Based Solutions (NBS) in the urban context has been cultivating interests lately from different scholars, urban planning practitioners and policymakers. This Special Issue originates from the Greening Cities Shaping Cities Symposium held at the Politecnico di Milano (12–13 October 2020), aiming at bridging the gap between the science and practice of implementing NBS in the built environment, as well as highlighting the importance of citizen participation in shared governance and policy making. The Special Issue was also made open to other contributions from outside the symposium in order to allow for contributions from a major scientific and practical audience wherever possible. Indeed, we have gathered contributions from Italy, Germany, the Netherlands, Turkey, Brazil, Portugal, Denmark, France, Bulgaria, Sweden, Hungary, Spain, the UAE, the UK, and the USA

[¹⁸F]fluorination of biorelevant arylboronic acid pinacol ester scaffolds synthesized by convergence techniques

Aim: The development of small molecules through convergent multicomponent reactions (MCR) has been boosted during the last decade due to the ability to synthesize, virtually without any side-products, numerous small drug-like molecules with several degrees of structural diversity.(1) The association of positron emission tomography (PET) labeling techniques in line with the “one-pot” development of biologically active compounds has the potential to become relevant not only for the evaluation and characterization of those MCR products through molecular imaging, but also to increase the library of radiotracers available. Therefore, since the [18F]fluorination of arylboronic acid pinacol ester derivatives tolerates electron-poor and electro-rich arenes and various functional groups,(2) the main goal of this research work was to achieve the 18F-radiolabeling of several different molecules synthesized through MCR. Materials and Methods: [18F]Fluorination of boronic acid pinacol esters was first extensively optimized using a benzaldehyde derivative in relation to the ideal amount of Cu(II) catalyst and precursor to be used, as well as the reaction solvent. Radiochemical conversion (RCC) yields were assessed by TLC-SG. The optimized radiolabeling conditions were subsequently applied to several structurally different MCR scaffolds comprising biologically relevant pharmacophores (e.g. β-lactam, morpholine, tetrazole, oxazole) that were synthesized to specifically contain a boronic acid pinacol ester group. Results: Radiolabeling with fluorine-18 was achieved with volumes (800 μl) and activities (≤ 2 GBq) compatible with most radiochemistry techniques and modules. In summary, an increase in the quantities of precursor or Cu(II) catalyst lead to higher conversion yields. An optimal amount of precursor (0.06 mmol) and Cu(OTf)2(py)4 (0.04 mmol) was defined for further reactions, with DMA being a preferential solvent over DMF. RCC yields from 15% to 76%, depending on the scaffold, were reproducibly achieved. Interestingly, it was noticed that the structure of the scaffolds, beyond the arylboronic acid, exerts some influence in the final RCC, with electron-withdrawing groups in the para position apparently enhancing the radiolabeling yield. Conclusion: The developed method with high RCC and reproducibility has the potential to be applied in line with MCR and also has a possibility to be incorporated in a later stage of this convergent “one-pot” synthesis strategy. Further studies are currently ongoing to apply this radiolabeling concept to fluorine-containing approved drugs whose boronic acid pinacol ester precursors can be synthesized through MCR (e.g. atorvastatin)

Across Space and Time Papers from the 41st Conference on Computer Applications and Quantitative Methods in Archaeology, Perth, 25-28 March 2013

The present volume includes 50 selected peer-reviewed papers presented at the 41st Computer Applications and Quantitative Methods in Archaeology Across Space and Time (CAA2013) conference held in Perth (Western Australia) in March 2013 at the University Club of Western Australia and hosted by the recently established CAA Australia National Chapter. It also hosts a paper presented at the 40th Computer Applications and Quantitative Methods in Archaeology (CAA2012) conference held in Southampton

Proceedings of the 19th Sound and Music Computing Conference

Proceedings of the 19th Sound and Music Computing Conference - June 5-12, 2022 - Saint-Étienne (France). https://smc22.grame.f