14,907 research outputs found
Unsupervised Lesion Detection via Image Restoration with a Normative Prior
Unsupervised lesion detection is a challenging problem that requires
accurately estimating normative distributions of healthy anatomy and detecting
lesions as outliers without training examples. Recently, this problem has
received increased attention from the research community following the advances
in unsupervised learning with deep learning. Such advances allow the estimation
of high-dimensional distributions, such as normative distributions, with higher
accuracy than previous methods.The main approach of the recently proposed
methods is to learn a latent-variable model parameterized with networks to
approximate the normative distribution using example images showing healthy
anatomy, perform prior-projection, i.e. reconstruct the image with lesions
using the latent-variable model, and determine lesions based on the differences
between the reconstructed and original images. While being promising, the
prior-projection step often leads to a large number of false positives. In this
work, we approach unsupervised lesion detection as an image restoration problem
and propose a probabilistic model that uses a network-based prior as the
normative distribution and detect lesions pixel-wise using MAP estimation. The
probabilistic model punishes large deviations between restored and original
images, reducing false positives in pixel-wise detections. Experiments with
gliomas and stroke lesions in brain MRI using publicly available datasets show
that the proposed approach outperforms the state-of-the-art unsupervised
methods by a substantial margin, +0.13 (AUC), for both glioma and stroke
detection. Extensive model analysis confirms the effectiveness of MAP-based
image restoration.Comment: Extended version of 'Unsupervised Lesion Detection via Image
Restoration with a Normative Prior' (MIDL2019
Towards segmentation and spatial alignment of the human embryonic brain using deep learning for atlas-based registration
We propose an unsupervised deep learning method for atlas based registration
to achieve segmentation and spatial alignment of the embryonic brain in a
single framework. Our approach consists of two sequential networks with a
specifically designed loss function to address the challenges in 3D first
trimester ultrasound. The first part learns the affine transformation and the
second part learns the voxelwise nonrigid deformation between the target image
and the atlas. We trained this network end-to-end and validated it against a
ground truth on synthetic datasets designed to resemble the challenges present
in 3D first trimester ultrasound. The method was tested on a dataset of human
embryonic ultrasound volumes acquired at 9 weeks gestational age, which showed
alignment of the brain in some cases and gave insight in open challenges for
the proposed method. We conclude that our method is a promising approach
towards fully automated spatial alignment and segmentation of embryonic brains
in 3D ultrasound
A Survey on Deep Learning in Medical Image Analysis
Deep learning algorithms, in particular convolutional networks, have rapidly
become a methodology of choice for analyzing medical images. This paper reviews
the major deep learning concepts pertinent to medical image analysis and
summarizes over 300 contributions to the field, most of which appeared in the
last year. We survey the use of deep learning for image classification, object
detection, segmentation, registration, and other tasks and provide concise
overviews of studies per application area. Open challenges and directions for
future research are discussed.Comment: Revised survey includes expanded discussion section and reworked
introductory section on common deep architectures. Added missed papers from
before Feb 1st 201
Medical imaging analysis with artificial neural networks
Given that neural networks have been widely reported in the research community of medical imaging, we provide a focused literature survey on recent neural network developments in computer-aided diagnosis, medical image segmentation and edge detection towards visual content analysis, and medical image registration for its pre-processing and post-processing, with the aims of increasing awareness of how neural networks can be applied to these areas and to provide a foundation for further research and practical development. Representative techniques and algorithms are explained in detail to provide inspiring examples illustrating: (i) how a known neural network with fixed structure and training procedure could be applied to resolve a medical imaging problem; (ii) how medical images could be analysed, processed, and characterised by neural networks; and (iii) how neural networks could be expanded further to resolve problems relevant to medical imaging. In the concluding section, a highlight of comparisons among many neural network applications is included to provide a global view on computational intelligence with neural networks in medical imaging
Hacia el modelado 3d de tumores cerebrales mediante endoneurosonografĂa y redes neuronales
Las cirugĂas mĂnimamente invasivas se han vuelto populares debido a que implican menos riesgos con respecto a las intervenciones tradicionales. En neurocirugĂa, las tendencias recientes sugieren el uso conjunto de la endoscopia y el ultrasonido, tĂ©cnica llamada endoneurosonografĂa (ENS), para la virtualizaciĂłn 3D de las estructuras del cerebro en tiempo real. La informaciĂłn ENS se puede utilizar para generar modelos 3D de los tumores del cerebro durante la cirugĂa. En este trabajo, presentamos una metodologĂa para el modelado 3D de tumores cerebrales con ENS y redes neuronales. EspecĂficamente, se estudiĂł el uso de mapas auto-organizados (SOM) y de redes neuronales tipo gas (NGN). En comparaciĂłn con otras tĂ©cnicas, el modelado 3D usando redes neuronales ofrece ventajas debido a que la morfologĂa del tumor se codifica directamente sobre los pesos sinápticos de la red, no requiere ningĂşn conocimiento a priori y la representaciĂłn puede ser desarrollada en dos etapas: entrenamiento fuera de lĂnea y adaptaciĂłn en lĂnea. Se realizan pruebas experimentales con maniquĂes mĂ©dicos de tumores cerebrales. Al final del documento, se presentan los resultados del modelado 3D a partir de una base de datos ENS.Minimally invasive surgeries have become popular because they reduce the typical risks of traditional interventions. In neurosurgery, recent trends suggest the combined use of endoscopy and ultrasound (endoneurosonography or ENS) for 3D virtualization of brain structures in real time. The ENS information can be used to generate 3D models of brain tumors during a surgery. This paper introduces a methodology for 3D modeling of brain tumors using ENS and unsupervised neural networks. The use of self-organizing maps (SOM) and neural gas networks (NGN) is particularly studied. Compared to other techniques, 3D modeling using neural networks offers advantages, since tumor morphology is directly encoded in synaptic weights of the network, no a priori knowledge is required, and the representation can be developed in two stages: off-line training and on-line adaptation. Experimental tests were performed using virtualized phantom brain tumors. At the end of the paper, the results of 3D modeling from an ENS database are presented
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