Video Registration in Egocentric Vision under Day and Night Illumination Changes

With the spread of wearable devices and head mounted cameras, a wide range of application requiring precise user localization is now possible. In this paper we propose to treat the problem of obtaining the user position with respect to a known environment as a video registration problem. Video registration, i.e. the task of aligning an input video sequence to a pre-built 3D model, relies on a matching process of local keypoints extracted on the query sequence to a 3D point cloud. The overall registration performance is strictly tied to the actual quality of this 2D-3D matching, and can degrade if environmental conditions such as steep changes in lighting like the ones between day and night occur. To effectively register an egocentric video sequence under these conditions, we propose to tackle the source of the problem: the matching process. To overcome the shortcomings of standard matching techniques, we introduce a novel embedding space that allows us to obtain robust matches by jointly taking into account local descriptors, their spatial arrangement and their temporal robustness. The proposal is evaluated using unconstrained egocentric video sequences both in terms of matching quality and resulting registration performance using different 3D models of historical landmarks. The results show that the proposed method can outperform state of the art registration algorithms, in particular when dealing with the challenges of night and day sequences

Learning to Find Eye Region Landmarks for Remote Gaze Estimation in Unconstrained Settings

Conventional feature-based and model-based gaze estimation methods have proven to perform well in settings with controlled illumination and specialized cameras. In unconstrained real-world settings, however, such methods are surpassed by recent appearance-based methods due to difficulties in modeling factors such as illumination changes and other visual artifacts. We present a novel learning-based method for eye region landmark localization that enables conventional methods to be competitive to latest appearance-based methods. Despite having been trained exclusively on synthetic data, our method exceeds the state of the art for iris localization and eye shape registration on real-world imagery. We then use the detected landmarks as input to iterative model-fitting and lightweight learning-based gaze estimation methods. Our approach outperforms existing model-fitting and appearance-based methods in the context of person-independent and personalized gaze estimation

A Deep Learning Framework for Unsupervised Affine and Deformable Image Registration

Image registration, the process of aligning two or more images, is the core technique of many (semi-)automatic medical image analysis tasks. Recent studies have shown that deep learning methods, notably convolutional neural networks (ConvNets), can be used for image registration. Thus far training of ConvNets for registration was supervised using predefined example registrations. However, obtaining example registrations is not trivial. To circumvent the need for predefined examples, and thereby to increase convenience of training ConvNets for image registration, we propose the Deep Learning Image Registration (DLIR) framework for \textit{unsupervised} affine and deformable image registration. In the DLIR framework ConvNets are trained for image registration by exploiting image similarity analogous to conventional intensity-based image registration. After a ConvNet has been trained with the DLIR framework, it can be used to register pairs of unseen images in one shot. We propose flexible ConvNets designs for affine image registration and for deformable image registration. By stacking multiple of these ConvNets into a larger architecture, we are able to perform coarse-to-fine image registration. We show for registration of cardiac cine MRI and registration of chest CT that performance of the DLIR framework is comparable to conventional image registration while being several orders of magnitude faster.Comment: Accepted: Medical Image Analysis - Elsevie

Optical Flow in Mostly Rigid Scenes

The optical flow of natural scenes is a combination of the motion of the observer and the independent motion of objects. Existing algorithms typically focus on either recovering motion and structure under the assumption of a purely static world or optical flow for general unconstrained scenes. We combine these approaches in an optical flow algorithm that estimates an explicit segmentation of moving objects from appearance and physical constraints. In static regions we take advantage of strong constraints to jointly estimate the camera motion and the 3D structure of the scene over multiple frames. This allows us to also regularize the structure instead of the motion. Our formulation uses a Plane+Parallax framework, which works even under small baselines, and reduces the motion estimation to a one-dimensional search problem, resulting in more accurate estimation. In moving regions the flow is treated as unconstrained, and computed with an existing optical flow method. The resulting Mostly-Rigid Flow (MR-Flow) method achieves state-of-the-art results on both the MPI-Sintel and KITTI-2015 benchmarks.Comment: 15 pages, 10 figures; accepted for publication at CVPR 201

Imaging Three-Dimensional Single Molecule Dynamics in its Cellular Context

Three-dimensional single molecule microscopy enables the study of dynamic processes in living cells at the level of individual molecules. Multifocal plane microscopy (MUM) is an example of such a modality and has been shown to be capable of capturing the rapid subcellular trafficking of single molecules in thick samples by simultaneously imaging distinct focal planes within the sample. Regardless of the specific modality, however, the obtained 3D trajectories of single molecules often do not fully reveal the biological significance of the observed dynamics. This is because the missing cellular context is often also needed in order to properly understand the events observed at the molecular level. We introduce the remote focusing-MUM (rMUM) modality, which enables 3D single molecule imaging with the simultaneous z-stack imaging of the surrounding cellular structures. Using rMUM, we demonstrate the 3D tracking of prostate-specific membrane antigen (PSMA) with a PSMA-specific antibody in a prostate cancer cell. PSMA is an important biomarker for prostate cancer cells. As such, it is a common target for antibody-based therapies. For example, of particular interest is the use of PSMA-specific antibodies that are conjugated with a toxin that kills prostate cancer cells. We analyze here the pathways of PSMA-specific antibodies, from prior to their first binding to PSMA at the plasma membrane to their arrival at, and continued movement in, sorting endosomes. By making possible the observation of single molecule dynamics within the relevant cellular context, rMUM allows, in our current application, the identification and analysis of different stages of the PSMA-specific antibody trafficking pathway