Electrical Impedance Tomography: From the Traditional Design to the Novel Frontier of Wearables

Electrical impedance tomography (EIT) is a medical imaging technique based on the injection of a current or voltage pattern through electrodes on the skin of the patient, and on the reconstruction of the internal conductivity distribution from the voltages collected by the electrodes. Compared to other imaging techniques, EIT shows significant advantages: it does not use ionizing radiation, is non-invasive and is characterized by high temporal resolution. Moreover, its low cost and high portability make it suitable for real-time, bedside monitoring. However, EIT is also characterized by some technical limitations that cause poor spatial resolution. The possibility to design wearable devices based on EIT has recently given a boost to this technology. In this paper we reviewed EIT physical principles, hardware design and major clinical applications, from the classical to a wearable setup. A wireless and wearable EIT system seems a promising frontier of this technology, as it can both facilitate making clinical measurements and open novel scenarios to EIT systems, such as home monitoring

Cuffless Blood Pressure in clinical practice: challenges, opportunities and current limits.

Background: Cuffless blood pressure measurement technologies have attracted significant attention for their potential to transform cardiovascular monitoring.Methods: This updated narrative review thoroughly examines the challenges, opportunities, and limitations associated with the implementation of cuffless blood pressure monitoring systems.Results: Diverse technologies, including photoplethysmography, tonometry, and ECG analysis, enable cuffless blood pressure measurement and are integrated into devices like smartphones and smartwatches. Signal processing emerges as a critical aspect, dictating the accuracy and reliability of readings. Despite its potential, the integration of cuffless technologies into clinical practice faces obstacles, including the need to address concerns related to accuracy, calibration, and standardization across diverse devices and patient populations. The development of robust algorithms to mitigate artifacts and environmental disturbances is essential for extracting clear physiological signals. Based on extensive research, this review emphasizes the necessity for standardized protocols, validation studies, and regulatory frameworks to ensure the reliability and safety of cuffless blood pressure monitoring devices and their implementation in mainstream medical practice. Interdisciplinary collaborations between engineers, clinicians, and regulatory bodies are crucial to address technical, clinical, and regulatory complexities during implementation. In conclusion, while cuffless blood pressure monitoring holds immense potential to transform cardiovascular care. The resolution of existing challenges and the establishment of rigorous standards are imperative for its seamless incorporation into routine clinical practice.Conclusion: The emergence of these new technologies shifts the paradigm of cardiovascular health management, presenting a new possibility for non-invasive continuous and dynamic monitoring. The concept of cuffless blood pressure measurement is viable and more finely tuned devices are expected to enter the market, which could redefine our understanding of blood pressure and hypertension

Mobile ECG Monitoring Device with Bioimpedance Measurement and Analysis

The paper describes the improvement of a portable ECG device, which allows increasing the reliability of cardiovascular disease diagnosis using an electrocardiogram during ambulatory monitoring in conditions of free motion activity. The results of hardware and software development for correction of an ECG form are presented, which minimizes the loss of diagnostic information due to the distortion of the ECG form by the bioimpedance of the tissues and organs of the body that are located between the heart and electrodes of an ECG device. A portable ECG device with a bioimpedance measurement channel between the electrodes is described. The measurement channel includes a programmable computing device. Software provides calculation based on the measurement results of the bioimpedance components of the parameters of the parasitic electric filter, and synthesis of the transfer characteristic of the correction digital filter. The simulation results of the correction procedure of the ECG form in the TINA environment are presented. The simulation results show that the proposed solution can be used in portable heart monitoring systems

MsWH: A multi-sensory hardware platform for capturing and analyzing physiological emotional signals

This paper presents a new physiological signal acquisition multi-sensory platform for emotion detection: Multi-sensor Wearable Headband (MsWH). The system is capable of recording and analyzing five different physiological signals: skin temperature, blood oxygen saturation, heart rate (and its variation), movement/position of the user (more specifically of his/her head) and electrodermal activity/bioimpedance. The measurement system is complemented by a porthole camera positioned in such a way that the viewing area remains constant. Thus, the user''s face will remain centered regardless of its position and movement, increasing the accuracy of facial expression recognition algorithms. This work specifies the technical characteristics of the developed device, paying special attention to both the hardware used (sensors, conditioning, microprocessors, connections) and the software, which is optimized for accurate and massive data acquisition. Although the information can be partially processed inside the device itself, the system is capable of sending information via Wi-Fi, with a very high data transfer rate, in case external processing is required. The most important features of the developed platform have been compared with those of a proven wearable device, namely the Empatica E4 wristband, in those measurements in which this is possible

Hybrid Nanostructured Textile Bioelectrode for Unobtrusive Health Monitoring

Coronary heart disease, cardiovascular diseases and strokes are the leading causes of mortality in United States of America. Timely point-of-care health diagnostics and therapeutics for person suffering from these diseases can save thousands of lives. However, lack of accessible minimally intrusive health monitoring systems makes timely diagnosis difficult and sometimes impossible. To remedy this problem, a textile based nano-bio-sensor was developed and evaluated in this research. The sensor was made of novel array of vertically standing nanostructures that are conductive nano-fibers projecting from a conductive fabric. These sensor electrodes were tested for the quality of electrical contact that they made with the skin based on the fundamental skin impedance model and electromagnetic theory. The hybrid nanostructured dry electrodes provided large surface area and better contact with skin that improved electrode sensitivity and reduced the effect of changing skin properties, which are the problems usually faced by conventional dry textile electrodes. The dry electrodes can only register strong physiological signals because of high background noise levels, thus limiting the use of existing dry electrodes to heart rate measurement and respiration. Therefore, dry electrode systems cannot be used for recording complete ECG waveform, EEG or measurement of bioimpedance. Because of their improved sensitivity these hybrid nanostructured dry electrodes can be applied to measurement of ECG and bioimpedance with very low baseline noise. These textile based electrodes can be seamlessly integrated into garments of daily use such as vests and bra. In combination with embedded wireless network device that can communicate with smart phone, laptop or GPRS, they can function as wearable wireless health diagnostic systems

Realization and Evaluation of the Device for Measuring the Impedance of Human Body for Detecting the Respiratory and Heart Rate

The idea of a device for measuring the impedance of human body with the target of monitoring the respiratory and heart rate is proposed in this paper. Hardware realization of the proposed idea is described with the illustration of the custom designed printed circuit board. Preparation of electrode shirts with various electrode placement configurations is introduced. Series of experimental measurements in the cases of dynamic bioimpedance reference and single human subject are described and results shown to evaluate the custom made device. The excitation frequencies in the range of 2 MHz– 20 MHz are utilized in the cases of large foil and textile electrodes to focus on the use of the capacitive connection to theobject – constituting the novelty of the current paper. The results are analysed concerning the dependency of the visual availability of the interesting signal of breathing and heart rate of the material and the placement of the electrodes. Availability of breathing is found to be evident in all of the experimented cases. The heart rate is found to be challenging because of the presence of high frequency noise

Advances in Assistive Electronic Device Solutions for Urology

Recent technology advances have led urology to become one of the leading specialities to utilise novel electronic systems to manage urological ailments. Contemporary bladder management strategies such as urinary catheters can provide a solution but leave the user mentally and physically debilitated. The unique properties of modern electronic devices, i.e., flexibility, stretchability, and biocompatibility, have allowed a plethora of new technologies to emerge. Many novel electronic device solutions in urology have been developed for treating impaired bladder disorders. These disorders include overactive bladder (OAB), underactive bladder (UAB) and other-urinary-affecting disorders (OUAD). This paper reviews common causes and conservative treatment strategies for OAB, UAB and OUAD, discussing the challenges and drawbacks of such treatments. Subsequently, this paper gives insight into clinically approved and research-based electronic advances in urology. Advances in this area cover bladder-stimulation and -monitoring devices, robot-assistive surgery, and bladder and sphincter prosthesis. This study aims to introduce the latest advances in electronic solutions for urology, comparing their advantages and disadvantages, and concluding with open problems for future urological device solutions

Portable detection of apnea and hypopnea events using bio-impedance of the chest and deep learning

Sleep apnea is one of the most common sleep-related breathing disorders. It is diagnosed through an overnight sleep study in a specialized sleep clinic. This setup is expensive and the number of beds and staff are limited, leading to a long waiting time. To enable more patients to be tested, and repeated monitoring for diagnosed patients, portable sleep monitoring devices are being developed. These devices automatically detect sleep apnea events in one or more respiration-related signals. There are multiple methods to measure respiration, with varying levels of signal quality and comfort for the patient. In this study, the potential of using the bio-impedance (bioZ) of the chest as a respiratory surrogate is analyzed. A novel portable device is presented, combined with a two-phase Long Short-Term Memory (LSTM) deep learning algorithm for automated event detection. The setup is benchmarked using simultaneous recordings of the device and the traditional polysomnography in 25 patients. The results demonstrate that using only the bioZ, an area under the precision-recall curve of 46.9% can be achieved, which is on par with automatic scoring using a polysomnography respiration channel. The sensitivity, specificity and accuracy are 58.4%, 76.2% and 72.8% respectively. This confirms the potential of using the bioZ device and deep learning algorithm for automatically detecting sleep respiration events during the night, in a portable and comfortable setup