Six questions on the construction of ontologies in biomedicine

(Report assembled for the Workshop of the AMIA Working Group on Formal Biomedical Knowledge Representation in connection with AMIA Symposium, Washington DC, 2005.) Best practices in ontology building for biomedicine have been frequently discussed in recent years. However there is a range of seemingly disparate views represented by experts in the field. These views not only reflect the different uses to which ontologies are put, but also the experiences and disciplinary background of these experts themselves. We asked six questions related to biomedical ontologies to what we believe is a representative sample of ontologists in the biomedical field and came to a number conclusions which we believe can help provide an insight into the practical problems which ontology builders face today

SYNTHNOTES: TOWARDS SYNTHETIC CLINICAL TEXT GENERATION

SynthNotes is a statistical natural language generation tool for the creation of realistic medical text notes for use by researchers in clinical language processing. Currently, advancements in medical analytics research face barriers due to patient privacy concerns which limits the numbers of researchers who have access to valuable data. Furthermore, privacy protections restrict the computing environments where data can be processed. This often adds prohibitive costs to researchers. The generation method described here provides domain-independent statistical methods for learning to generate text by extracting and ranking templates from a training corpus. The primary contribution in this work is automating the process of template selection and generation of text through classic machine learning methods. SynthNotes removes the need for human domain experts to construct templates, which can be time intensive and expensive. Furthermore, by using machine learning methods, this approach leads to greater realism and variability in the generated notes than could be achieved through classical language generation methods

Knowledge-based Biomedical Data Science 2019

Knowledge-based biomedical data science (KBDS) involves the design and implementation of computer systems that act as if they knew about biomedicine. Such systems depend on formally represented knowledge in computer systems, often in the form of knowledge graphs. Here we survey the progress in the last year in systems that use formally represented knowledge to address data science problems in both clinical and biological domains, as well as on approaches for creating knowledge graphs. Major themes include the relationships between knowledge graphs and machine learning, the use of natural language processing, and the expansion of knowledge-based approaches to novel domains, such as Chinese Traditional Medicine and biodiversity.Comment: Manuscript 43 pages with 3 tables; Supplemental material 43 pages with 3 table

Neurocognitive Informatics Manifesto.

Informatics studies all aspects of the structure of natural and artificial information systems. Theoretical and abstract approaches to information have made great advances, but human information processing is still unmatched in many areas, including information management, representation and understanding. Neurocognitive informatics is a new, emerging field that should help to improve the matching of artificial and natural systems, and inspire better computational algorithms to solve problems that are still beyond the reach of machines. In this position paper examples of neurocognitive inspirations and promising directions in this area are given