Hybrid Nanostructured Textile Bioelectrode for Unobtrusive Health Monitoring

Coronary heart disease, cardiovascular diseases and strokes are the leading causes of mortality in United States of America. Timely point-of-care health diagnostics and therapeutics for person suffering from these diseases can save thousands of lives. However, lack of accessible minimally intrusive health monitoring systems makes timely diagnosis difficult and sometimes impossible. To remedy this problem, a textile based nano-bio-sensor was developed and evaluated in this research. The sensor was made of novel array of vertically standing nanostructures that are conductive nano-fibers projecting from a conductive fabric. These sensor electrodes were tested for the quality of electrical contact that they made with the skin based on the fundamental skin impedance model and electromagnetic theory. The hybrid nanostructured dry electrodes provided large surface area and better contact with skin that improved electrode sensitivity and reduced the effect of changing skin properties, which are the problems usually faced by conventional dry textile electrodes. The dry electrodes can only register strong physiological signals because of high background noise levels, thus limiting the use of existing dry electrodes to heart rate measurement and respiration. Therefore, dry electrode systems cannot be used for recording complete ECG waveform, EEG or measurement of bioimpedance. Because of their improved sensitivity these hybrid nanostructured dry electrodes can be applied to measurement of ECG and bioimpedance with very low baseline noise. These textile based electrodes can be seamlessly integrated into garments of daily use such as vests and bra. In combination with embedded wireless network device that can communicate with smart phone, laptop or GPRS, they can function as wearable wireless health diagnostic systems

Multidimensional embedded MEMS motion detectors for wearable mechanocardiography and 4D medical imaging

Background: Cardiovascular diseases are the number one cause of death. Of these deaths, almost 80% are due to coronary artery disease (CAD) and cerebrovascular disease. Multidimensional microelectromechanical systems (MEMS) sensors allow measuring the mechanical movement of the heart muscle offering an entirely new and innovative solution to evaluate cardiac rhythm and function. Recent advances in miniaturized motion sensors present an exciting opportunity to study novel device-driven and functional motion detection systems in the areas of both cardiac monitoring and biomedical imaging, for example, in computed tomography (CT) and positron emission tomography (PET). Methods: This Ph.D. work describes a new cardiac motion detection paradigm and measurement technology based on multimodal measuring tools — by tracking the heart’s kinetic activity using micro-sized MEMS sensors — and novel computational approaches — by deploying signal processing and machine learning techniques—for detecting cardiac pathological disorders. In particular, this study focuses on the capability of joint gyrocardiography (GCG) and seismocardiography (SCG) techniques that constitute the mechanocardiography (MCG) concept representing the mechanical characteristics of the cardiac precordial surface vibrations. Results: Experimental analyses showed that integrating multisource sensory data resulted in precise estimation of heart rate with an accuracy of 99% (healthy, n=29), detection of heart arrhythmia (n=435) with an accuracy of 95-97%, ischemic disease indication with approximately 75% accuracy (n=22), as well as significantly improved quality of four-dimensional (4D) cardiac PET images by eliminating motion related inaccuracies using MEMS dual gating approach. Tissue Doppler imaging (TDI) analysis of GCG (healthy, n=9) showed promising results for measuring the cardiac timing intervals and myocardial deformation changes. Conclusion: The findings of this study demonstrate clinical potential of MEMS motion sensors in cardiology that may facilitate in time diagnosis of cardiac abnormalities. Multidimensional MCG can effectively contribute to detecting atrial fibrillation (AFib), myocardial infarction (MI), and CAD. Additionally, MEMS motion sensing improves the reliability and quality of cardiac PET imaging.Moniulotteisten sulautettujen MEMS-liiketunnistimien käyttö sydänkardiografiassa sekä lääketieteellisessä 4D-kuvantamisessa Tausta: Sydän- ja verisuonitaudit ovat yleisin kuolinsyy. Näistä kuolemantapauksista lähes 80% johtuu sepelvaltimotaudista (CAD) ja aivoverenkierron häiriöistä. Moniulotteiset mikroelektromekaaniset järjestelmät (MEMS) mahdollistavat sydänlihaksen mekaanisen liikkeen mittaamisen, mikä puolestaan tarjoaa täysin uudenlaisen ja innovatiivisen ratkaisun sydämen rytmin ja toiminnan arvioimiseksi. Viimeaikaiset teknologiset edistysaskeleet mahdollistavat uusien pienikokoisten liiketunnistusjärjestelmien käyttämisen sydämen toiminnan tutkimuksessa sekä lääketieteellisen kuvantamisen, kuten esimerkiksi tietokonetomografian (CT) ja positroniemissiotomografian (PET), tarkkuuden parantamisessa. Menetelmät: Tämä väitöskirjatyö esittelee uuden sydämen kineettisen toiminnan mittaustekniikan, joka pohjautuu MEMS-anturien käyttöön. Uudet laskennalliset lähestymistavat, jotka perustuvat signaalinkäsittelyyn ja koneoppimiseen, mahdollistavat sydämen patologisten häiriöiden havaitsemisen MEMS-antureista saatavista signaaleista. Tässä tutkimuksessa keskitytään erityisesti mekanokardiografiaan (MCG), joihin kuuluvat gyrokardiografia (GCG) ja seismokardiografia (SCG). Näiden tekniikoiden avulla voidaan mitata kardiorespiratorisen järjestelmän mekaanisia ominaisuuksia. Tulokset: Kokeelliset analyysit osoittivat, että integroimalla usean sensorin dataa voidaan mitata syketiheyttä 99% (terveillä n=29) tarkkuudella, havaita sydämen rytmihäiriöt (n=435) 95-97%, tarkkuudella, sekä havaita iskeeminen sairaus noin 75% tarkkuudella (n=22). Lisäksi MEMS-kaksoistahdistuksen avulla voidaan parantaa sydämen 4D PET-kuvan laatua, kun liikeepätarkkuudet voidaan eliminoida paremmin. Doppler-kuvantamisessa (TDI, Tissue Doppler Imaging) GCG-analyysi (terveillä, n=9) osoitti lupaavia tuloksia sydänsykkeen ajoituksen ja intervallien sekä sydänlihasmuutosten mittaamisessa. Päätelmä: Tämän tutkimuksen tulokset osoittavat, että kardiologisilla MEMS-liikeantureilla on kliinistä potentiaalia sydämen toiminnallisten poikkeavuuksien diagnostisoinnissa. Moniuloitteinen MCG voi edistää eteisvärinän (AFib), sydäninfarktin (MI) ja CAD:n havaitsemista. Lisäksi MEMS-liiketunnistus parantaa sydämen PET-kuvantamisen luotettavuutta ja laatua

Electrical Impedance Tomography for Biomedical Applications: Circuits and Systems Review

There has been considerable interest in electrical impedance tomography (EIT) to provide low-cost, radiation-free, real-time and wearable means for physiological status monitoring. To be competitive with other well-established imaging modalities, it is important to understand the requirements of the specific application and determine a suitable system design. This paper presents an overview of EIT circuits and systems including architectures, current drivers, analog front-end and demodulation circuits, with emphasis on integrated circuit implementations. Commonly used circuit topologies are detailed, and tradeoffs are discussed to aid in choosing an appropriate design based on the application and system priorities. The paper also describes a number of integrated EIT systems for biomedical applications, as well as discussing current challenges and possible future directions

Microscale 3-D Capacitance Tomography with a CMOS Sensor Array

Electrical capacitance tomography (ECT) is a nonoptical imaging technique in which a map of the interior permittivity of a volume is estimated by making capacitance measurements at its boundary and solving an inverse problem. While previous ECT demonstrations have often been at centimeter scales, ECT is not limited to macroscopic systems. In this paper, we demonstrate ECT imaging of polymer microspheres and bacterial biofilms using a CMOS microelectrode array, achieving spatial resolution of 10 microns. Additionally, we propose a deep learning architecture and an improved multi-objective training scheme for reconstructing out-of-plane permittivity maps from the sensor measurements. Experimental results show that the proposed approach is able to resolve microscopic 3-D structures, achieving 91.5% prediction accuracy on the microsphere dataset and 82.7% on the biofilm dataset, including an average of 4.6% improvement over baseline computational methods

Sensor Developments for Electrophysiological Monitoring in Healthcare

Recent years have seen a renewal of interest in the development of sensor systems which can be used to monitor electrophysiological signals in a number of different settings. These include clinical, outside of the clinical setting with the subject ambulatory and going about their daily lives, and over long periods. The primary impetus for this is the challenge of providing healthcare for the ageing population based on home health monitoring, telehealth and telemedicine. Another stimulus is the demand for life sign monitoring of critical personnel such as fire fighters and military combatants. A related area of interest which, whilst not in the category of healthcare, utilises many of the same approaches, is that of sports physiology for both professional athletes and for recreation. Clinical diagnosis of conditions in, for example, cardiology and neurology remain based on conventional sensors, using established electrodes and well understood electrode placements. However, the demands of long term health monitoring, rehabilitation support and assistive technology for the disabled and elderly are leading research groups such as ours towards novel sensors, wearable and wireless enabled systems and flexible sensor arrays

Miniaturized antenna and transponder based wireless sensors for internet of things in healthcare

Future medical and healthcare systems will be largely improved by the wide-spreading of internet of things (IoTs). One of the crucial challenges of IoTs for healthcare is at the wireless sensors. Miniaturization of sensor node profile, minimizing power consumption as well as lowering down design/production cost of antenna, RF circuits and sensor modules have become the key issues for realizing more exciting applications in medical and healthcare fields that never seemed to be possible before. In this dissertation work, we first focus on electrically small antenna (ESA) design and fabrication for medical telemetry. A comprehensive analysis of the radiation properties of a novel electrically small folded ellipsoidal ESA is presented, showing its ability to self-resonate and impedance match without external components. It will benefit various size-restricted applications especially with wireless medical implants. The second focus is on healthcare sensors using ESA as the sensing agent, which saves the power and cost by eliminating the need of extra sensing modules. Specifically, miniaturized helix ESAs are integrated with drug reservoirs to function as wireless transponder sensors for real-time drug dosage monitoring. We also introduce a system level innovation of a passive wireless harmonic transponder/harmonic sniffer/frequency hopped interrogator based sensing system. The μL- liquid level resolution and absolute-accuracy passive sensing is demonstrated in the presence of strong direct coupling, background scatters, distance variance as well as near-filed human body movement interference. Furthermore, we investigate how modern ubiquitous wireless sensor networks could take advantage of sensitive nanostructure materials for enhanced performance. Here we propose a new paradigm of chemically-gated mixed modulation on a single homogeneous graphene device in which the chemical exposure directly modulates an electrical carrier signal. To make the device ubiquitously reusable, a method of precisely tuning the charge neutrality point (Vcnp) is introduced by electrochemical calibration with gate voltage pulse sequence. Such chemically gated graphene modulator can be potentially used in a harmonic transponder as a passive ubiquitous sensor node for chemical and bio sensing applications. Overall the research work presented in the dissertation will help enable cost and power-efficient wireless sensor networks in future healthcare IoTs.Electrical and Computer Engineerin

Development of a cell sensing and electrotherapeutic system for a smart stent

Cardiovascular diseases (CVD) is one of the main causes of death worldwide. Coronary heart disease (CHD) and strokes are the highest contributors to CVD deaths (46 % and 26 % respectively) in the UK. The condition which leads to CHD is Coronary artery disease (CAD). The main cause of CAD is coronary atherosclerosis, which involves an inflammatory response of the artery wall to chronic multifactorial injury, which then results into formation of atherosclerotic plaques. One of the main treatment strategies for CAD is Percutaneous Coronary Intervention (PCI). PCI is a procedure during which a balloon mounted catheter with an unexpanded stent is inserted into a peripheral artery and threaded up to the site of stenosis in the coronary artery of the heart to reopen the vessel. PCI usually involves stenting with a Bare Metal Stent (BMS) or Drug Eluting Stent (DES). The 9-month revascularisation rate is 12.32 % with BMS, and this rate has significantly decreased to 4.34 % with early generation DES. The latest generation of DES is associated with revascularisation rates of 2.91 %. Detection of this vascular hyperplasia is a common limitation of these devices which can be found across a number of vascular pathologies. In this project, we developed a new type of biosensor for detecting the changes associated with these blockages that could be mounted on these implantable medical devices. Our design and development led to a comprehensive characterisation of both the sensor and its cell interactions. Proof of concept experiments were performed that legitimised the concept of a smart self-reporting device, as a solution to remote detection of In-stent Restenosis (ISR). The proposed smart stent would have both diagnostic and therapeutic capabilities. Preliminary tests showed that the devices were minimally susceptible to changes in volume and conductivity of culture medium, during baseline measurements. Sensors of different dimensions were fabricated with the best version 16 times smaller but with 4.35 times higher sensitivity in cell detection compared to baseline. Our sensor could also distinguish between different cell types. Indeed the sensor coverage could be remotely monitored intermittently (at 24 h intervals) or continuously (at 15 min intervals) or on demand. Continuous monitoring allowed the gradual changes in cell phenotype to be monitored including cell adherence, proliferation and death which was then correlated with live cell sensor imaging. We found our sensors could be used for both cell detection and therapeutic intervention. As the fabricated biosensors are intended to be integrated onto a future smart stent, this would be implanted in vivo and would be subjected to blood flow. Therefore it was important to test the devices under flow conditions. Our data show that, when incorporated into microfluidic flow chambers, the sensors could exquisitely detect cell adherence under flow and static conditions. Moreover they were also suitable for monitoring the gradual migration and proliferation of vascular cells within a microfluidic channel. Future development of these proof-of-concept biosensors is critical for future commercialisation of this important novel device, which hopefully will provide a new class of diagnostic and therapeutic vascular devices