A Process Modelling Framework Based on Point Interval Temporal Logic with an Application to Modelling Patient Flows

This thesis considers an application of a temporal theory to describe and model the patient journey in the hospital accident and emergency (A&E) department. The aim is to introduce a generic but dynamic method applied to any setting, including healthcare. Constructing a consistent process model can be instrumental in streamlining healthcare issues. Current process modelling techniques used in healthcare such as flowcharts, unified modelling language activity diagram (UML AD), and business process modelling notation (BPMN) are intuitive and imprecise. They cannot fully capture the complexities of the types of activities and the full extent of temporal constraints to an extent where one could reason about the flows. Formal approaches such as Petri have also been reviewed to investigate their applicability to the healthcare domain to model processes. Additionally, to schedule patient flows, current modelling standards do not offer any formal mechanism, so healthcare relies on critical path method (CPM) and program evaluation review technique (PERT), that also have limitations, i.e. finish-start barrier. It is imperative to specify the temporal constraints between the start and/or end of a process, e.g., the beginning of a process A precedes the start (or end) of a process B. However, these approaches failed to provide us with a mechanism for handling these temporal situations. If provided, a formal representation can assist in effective knowledge representation and quality enhancement concerning a process. Also, it would help in uncovering complexities of a system and assist in modelling it in a consistent way which is not possible with the existing modelling techniques. The above issues are addressed in this thesis by proposing a framework that would provide a knowledge base to model patient flows for accurate representation based on point interval temporal logic (PITL) that treats point and interval as primitives. These objects would constitute the knowledge base for the formal description of a system. With the aid of the inference mechanism of the temporal theory presented here, exhaustive temporal constraints derived from the proposed axiomatic system’ components serves as a knowledge base. The proposed methodological framework would adopt a model-theoretic approach in which a theory is developed and considered as a model while the corresponding instance is considered as its application. Using this approach would assist in identifying core components of the system and their precise operation representing a real-life domain deemed suitable to the process modelling issues specified in this thesis. Thus, I have evaluated the modelling standards for their most-used terminologies and constructs to identify their key components. It will also assist in the generalisation of the critical terms (of process modelling standards) based on their ontology. A set of generalised terms proposed would serve as an enumeration of the theory and subsume the core modelling elements of the process modelling standards. The catalogue presents a knowledge base for the business and healthcare domains, and its components are formally defined (semantics). Furthermore, a resolution theorem-proof is used to show the structural features of the theory (model) to establish it is sound and complete. After establishing that the theory is sound and complete, the next step is to provide the instantiation of the theory. This is achieved by mapping the core components of the theory to their corresponding instances. Additionally, a formal graphical tool termed as point graph (PG) is used to visualise the cases of the proposed axiomatic system. PG facilitates in modelling, and scheduling patient flows and enables analysing existing models for possible inaccuracies and inconsistencies supported by a reasoning mechanism based on PITL. Following that, a transformation is developed to map the core modelling components of the standards into the extended PG (PG*) based on the semantics presented by the axiomatic system. A real-life case (from the King’s College hospital accident and emergency (A&E) department’s trauma patient pathway) is considered to validate the framework. It is divided into three patient flows to depict the journey of a patient with significant trauma, arriving at A&E, undergoing a procedure and subsequently discharged. Their staff relied upon the UML-AD and BPMN to model the patient flows. An evaluation of their representation is presented to show the shortfalls of the modelling standards to model patient flows. The last step is to model these patient flows using the developed approach, which is supported by enhanced reasoning and scheduling

Theorem proving support in programming language semantics

We describe several views of the semantics of a simple programming language as formal documents in the calculus of inductive constructions that can be verified by the Coq proof system. Covered aspects are natural semantics, denotational semantics, axiomatic semantics, and abstract interpretation. Descriptions as recursive functions are also provided whenever suitable, thus yielding a a verification condition generator and a static analyser that can be run inside the theorem prover for use in reflective proofs. Extraction of an interpreter from the denotational semantics is also described. All different aspects are formally proved sound with respect to the natural semantics specification.Comment: Propos\'e pour publication dans l'ouvrage \`a la m\'emoire de Gilles Kah

Mechanized semantics

The goal of this lecture is to show how modern theorem provers---in this case, the Coq proof assistant---can be used to mechanize the specification of programming languages and their semantics, and to reason over individual programs and over generic program transformations, as typically found in compilers. The topics covered include: operational semantics (small-step, big-step, definitional interpreters); a simple form of denotational semantics; axiomatic semantics and Hoare logic; generation of verification conditions, with application to program proof; compilation to virtual machine code and its proof of correctness; an example of an optimizing program transformation (dead code elimination) and its proof of correctness

Generic Trace Semantics via Coinduction

Trace semantics has been defined for various kinds of state-based systems, notably with different forms of branching such as non-determinism vs. probability. In this paper we claim to identify one underlying mathematical structure behind these "trace semantics," namely coinduction in a Kleisli category. This claim is based on our technical result that, under a suitably order-enriched setting, a final coalgebra in a Kleisli category is given by an initial algebra in the category Sets. Formerly the theory of coalgebras has been employed mostly in Sets where coinduction yields a finer process semantics of bisimilarity. Therefore this paper extends the application field of coalgebras, providing a new instance of the principle "process semantics via coinduction."Comment: To appear in Logical Methods in Computer Science. 36 page