A Process Modelling Framework Based on Point Interval Temporal Logic with an Application to Modelling Patient Flows

This thesis considers an application of a temporal theory to describe and model the patient journey in the hospital accident and emergency (A&E) department. The aim is to introduce a generic but dynamic method applied to any setting, including healthcare. Constructing a consistent process model can be instrumental in streamlining healthcare issues. Current process modelling techniques used in healthcare such as flowcharts, unified modelling language activity diagram (UML AD), and business process modelling notation (BPMN) are intuitive and imprecise. They cannot fully capture the complexities of the types of activities and the full extent of temporal constraints to an extent where one could reason about the flows. Formal approaches such as Petri have also been reviewed to investigate their applicability to the healthcare domain to model processes. Additionally, to schedule patient flows, current modelling standards do not offer any formal mechanism, so healthcare relies on critical path method (CPM) and program evaluation review technique (PERT), that also have limitations, i.e. finish-start barrier. It is imperative to specify the temporal constraints between the start and/or end of a process, e.g., the beginning of a process A precedes the start (or end) of a process B. However, these approaches failed to provide us with a mechanism for handling these temporal situations. If provided, a formal representation can assist in effective knowledge representation and quality enhancement concerning a process. Also, it would help in uncovering complexities of a system and assist in modelling it in a consistent way which is not possible with the existing modelling techniques. The above issues are addressed in this thesis by proposing a framework that would provide a knowledge base to model patient flows for accurate representation based on point interval temporal logic (PITL) that treats point and interval as primitives. These objects would constitute the knowledge base for the formal description of a system. With the aid of the inference mechanism of the temporal theory presented here, exhaustive temporal constraints derived from the proposed axiomatic system’ components serves as a knowledge base. The proposed methodological framework would adopt a model-theoretic approach in which a theory is developed and considered as a model while the corresponding instance is considered as its application. Using this approach would assist in identifying core components of the system and their precise operation representing a real-life domain deemed suitable to the process modelling issues specified in this thesis. Thus, I have evaluated the modelling standards for their most-used terminologies and constructs to identify their key components. It will also assist in the generalisation of the critical terms (of process modelling standards) based on their ontology. A set of generalised terms proposed would serve as an enumeration of the theory and subsume the core modelling elements of the process modelling standards. The catalogue presents a knowledge base for the business and healthcare domains, and its components are formally defined (semantics). Furthermore, a resolution theorem-proof is used to show the structural features of the theory (model) to establish it is sound and complete. After establishing that the theory is sound and complete, the next step is to provide the instantiation of the theory. This is achieved by mapping the core components of the theory to their corresponding instances. Additionally, a formal graphical tool termed as point graph (PG) is used to visualise the cases of the proposed axiomatic system. PG facilitates in modelling, and scheduling patient flows and enables analysing existing models for possible inaccuracies and inconsistencies supported by a reasoning mechanism based on PITL. Following that, a transformation is developed to map the core modelling components of the standards into the extended PG (PG*) based on the semantics presented by the axiomatic system. A real-life case (from the King’s College hospital accident and emergency (A&E) department’s trauma patient pathway) is considered to validate the framework. It is divided into three patient flows to depict the journey of a patient with significant trauma, arriving at A&E, undergoing a procedure and subsequently discharged. Their staff relied upon the UML-AD and BPMN to model the patient flows. An evaluation of their representation is presented to show the shortfalls of the modelling standards to model patient flows. The last step is to model these patient flows using the developed approach, which is supported by enhanced reasoning and scheduling

Genuine lab experiences for students in resource constrained environments: The RealLab with integrated intelligent assessment.

Laboratory activities are indispensable for developing engineering skills. Computer Aided Learning (CAL) tools can be used to enhance laboratory learning in various ways, the latest approach being the virtual laboratory technique that emulates traditional laboratory processes. This new approach makes it possible to give students complete and genuine laboratory experiences in situations constrained by limited resources in the provision of laboratory facilities and infrastructure and/or where there is need for laboratory education, for large classes, with only one laboratory stand. This may especially be the case in countries in transition. Most existing virtual laboratories are not available for purchase. Where they are, they may not be cost friendly for resource constrained environments. Also, most do not integrate any form of assessment structure. In this paper, we present a very cost friendly virtual laboratory solution for genuine laboratory experiences in resource constrained environments, with integrated intelligent assessment

Formalising responsibility modelling for automatic analysis

Modelling the structure of social-technical systems as a basis for informing software system design is a difficult compromise. Formal methods struggle to capture the scale and complexity of the heterogeneous organisations that use technical systems. Conversely, informal approaches lack the rigour needed to inform the software design and construction process or enable automated analysis. We revisit the concept of responsibility modelling, which models social technical systems as a collection of actors who discharge their responsibilities, whilst using and producing resources in the process. Responsibility modelling is formalised as a structured approach for socio-technical system requirements specification and modelling, with well-defined semantics and support for automated structure and validity analysis. The effectiveness of the approach is demonstrated by two case studies of software engineering methodologies

A Decidable Characterization of a Graphical Pi-calculus with Iterators

This paper presents the Pi-graphs, a visual paradigm for the modelling and verification of mobile systems. The language is a graphical variant of the Pi-calculus with iterators to express non-terminating behaviors. The operational semantics of Pi-graphs use ground notions of labelled transition and bisimulation, which means standard verification techniques can be applied. We show that bisimilarity is decidable for the proposed semantics, a result obtained thanks to an original notion of causal clock as well as the automatic garbage collection of unused names.Comment: In Proceedings INFINITY 2010, arXiv:1010.611

A comparative analysis of business process modelling techniques

Business process modelling is an increasingly popular research area for both organisations and academia due to its usefulness in facilitating human understanding and communication. Several modelling techniques have been proposed and used to capture the characteristics of business processes. However, available techniques view business processes from different perspectives and have different features and capabilities. Furthermore, to date limited guidelines exist for selecting appropriate modelling techniques based on the characteristics of the problem and its requirements. This paper presents a comparative analysis of some popular business process modelling techniques. The comparative framework is based on five criteria: flexibility, ease of use, understandability, simulation support and scope. The study highlights some of the major paradigmatic differences between the techniques. The proposed framework can serve as the basis for evaluating further modelling techniques and generating selection procedures

Engineering simulations for cancer systems biology

Computer simulation can be used to inform in vivo and in vitro experimentation, enabling rapid, low-cost hypothesis generation and directing experimental design in order to test those hypotheses. In this way, in silico models become a scientific instrument for investigation, and so should be developed to high standards, be carefully calibrated and their findings presented in such that they may be reproduced. Here, we outline a framework that supports developing simulations as scientific instruments, and we select cancer systems biology as an exemplar domain, with a particular focus on cellular signalling models. We consider the challenges of lack of data, incomplete knowledge and modelling in the context of a rapidly changing knowledge base. Our framework comprises a process to clearly separate scientific and engineering concerns in model and simulation development, and an argumentation approach to documenting models for rigorous way of recording assumptions and knowledge gaps. We propose interactive, dynamic visualisation tools to enable the biological community to interact with cellular signalling models directly for experimental design. There is a mismatch in scale between these cellular models and tissue structures that are affected by tumours, and bridging this gap requires substantial computational resource. We present concurrent programming as a technology to link scales without losing important details through model simplification. We discuss the value of combining this technology, interactive visualisation, argumentation and model separation to support development of multi-scale models that represent biologically plausible cells arranged in biologically plausible structures that model cell behaviour, interactions and response to therapeutic interventions

e-Social Science and Evidence-Based Policy Assessment : Challenges and Solutions

Peer reviewedPreprin

Toward the automation of business process ontology generation

Semantic Business Process Management (SBPM) utilises semantic technologies (e.g., ontology) to model and query process representations. There are times in which such models must be reconstructed from existing textual documentation. In this scenario the automated generation of ontological models would be preferable, however current methods and technology are still not capable of automatically generating accurate semantic process models from textual descriptions. This research attempts to automate the process as much as possible by proposing a method that drives the transformation through the joint use of a foundational ontology and lexico-semantic analysis. The method is presented, demonstrated and evaluated. The original dataset represents 150 business activities related to the procurement processes of a case study company. As the evaluation shows, the proposed method can accurately map the linguistic patterns of the process descriptions to semantic patterns of the foundational ontology to a high level of accuracy, however further research is required in order to reduce the level of human intervention, expand the method so as to recognise further patterns of the foundational ontology and develop a tool to assist the business process modeller in the semi-automated generation of process models