Quantum metrology and its application in biology

Quantum metrology provides a route to overcome practical limits in sensing devices. It holds particular relevance to biology, where sensitivity and resolution constraints restrict applications both in fundamental biophysics and in medicine. Here, we review quantum metrology from this biological context, focusing on optical techniques due to their particular relevance for biological imaging, sensing, and stimulation. Our understanding of quantum mechanics has already enabled important applications in biology, including positron emission tomography (PET) with entangled photons, magnetic resonance imaging (MRI) using nuclear magnetic resonance, and bio-magnetic imaging with superconducting quantum interference devices (SQUIDs). In quantum metrology an even greater range of applications arise from the ability to not just understand, but to engineer, coherence and correlations at the quantum level. In the past few years, quite dramatic progress has been seen in applying these ideas into biological systems. Capabilities that have been demonstrated include enhanced sensitivity and resolution, immunity to imaging artifacts and technical noise, and characterization of the biological response to light at the single-photon level. New quantum measurement techniques offer even greater promise, raising the prospect for improved multi-photon microscopy and magnetic imaging, among many other possible applications. Realization of this potential will require cross-disciplinary input from researchers in both biology and quantum physics. In this review we seek to communicate the developments of quantum metrology in a way that is accessible to biologists and biophysicists, while providing sufficient detail to allow the interested reader to obtain a solid understanding of the field. We further seek to introduce quantum physicists to some of the central challenges of optical measurements in biological science.Comment: Submitted review article, comments and suggestions welcom

Measuring coherence of quantum measurements

The superposition of quantum states lies at the heart of physics and has been recently found to serve as a versatile resource for quantum information protocols, defining the notion of quantum coherence. In this contribution, we report on the implementation of its complementary concept, coherence from quantum measurements. By devising an accessible criterion which holds true in any classical statistical theory, we demonstrate that noncommutative quantum measurements violate this constraint, rendering it possible to perform an operational assessment of the measurement-based quantum coherence. In particular, we verify that polarization measurements of a single photonic qubit, an essential carrier of one unit of quantum information, are already incompatible with classical, i.e., incoherent, models of a measurement apparatus. Thus, we realize a method that enables us to quantitatively certify which quantum measurements follow fundamentally different statistical laws than expected from classical theories and, at the same time, quantify their usefulness within the modern framework of resources for quantum information technology.Comment: close to published versio

Inhibiting decoherence via ancilla processes

General conditions are derived for preventing the decoherence of a single two-state quantum system (qubit) in a thermal bath. The employed auxiliary systems required for this purpose are merely assumed to be weak for the general condition while various examples such as extra qubits and extra classical fields are studied for applications in quantum information processing. The general condition is confirmed with well known approaches towards inhibiting decoherence. A novel approach for decoherence-free quantum memories and quantum operations is presented by placing the qubit into the center of a sphere with extra qubits on its surface.Comment: pages 8, Revtex

Quantum Memories. A Review based on the European Integrated Project "Qubit Applications (QAP)"

We perform a review of various approaches to the implementation of quantum memories, with an emphasis on activities within the quantum memory sub-project of the EU Integrated Project "Qubit Applications". We begin with a brief overview over different applications for quantum memories and different types of quantum memories. We discuss the most important criteria for assessing quantum memory performance and the most important physical requirements. Then we review the different approaches represented in "Qubit Applications" in some detail. They include solid-state atomic ensembles, NV centers, quantum dots, single atoms, atomic gases and optical phonons in diamond. We compare the different approaches using the discussed criteria.Comment: 22 pages, 12 figure

Many-body quantum coherence and interaction blockade in Josephson-linked Bose-Einstein condensates

We study many-body quantum coherence and interaction blockade in two Josephson-linked Bose-Einstein condensates. We introduce universal operators for characterizing many-body coherence without limitations on the system symmetry and total particle number $N$. We reproduce the results for both coherence fluctuations and number squeezing in {\em symmetric} systems of large $N$, and reveal several peculiar phenomena that may occur in {\em asymmetric} systems and systems of small $N$. For asymmetric systems, we show that, due to an interplay between asymmetry and inter-particle interaction, the coherence fluctuations are suppressed dramatically when $|E_{C}/E_{J}|\ll 1$, and both {\it resonant tunneling} and {\it interaction blockade} take place for large values of $|E_{C}/E_{J}|$, where $E_C$ and $E_J$ are the interaction and tunneling energies, respectively. We emphasize that the resonant tunneling and interaction blockade may allow creating single-atom devices with promising technology applications. We demonstrate that for the systems at finite temperatures the formation of self-trapped states causes an anomalous behavior.Comment: 6 pages, 5 figures, accepted for publication in EPL (Europhysics Letters