Byars-Hall High School, Covington, Tennessee, Senior Follies program, 1937

Program of the Senior follies performed by the Senior Class of Byars-Hall High School, Covington, Tennessee, on May 20, 1937.https://digitalcommons.memphis.edu/speccoll-mss-cpsimontonfamily1/1020/thumbnail.jp

On time scales and time synchronization using LORAN-C as a time reference signal

The long term performance of the eight LORAN-C chains is presented in terms of the Coordinated Universal Time (UTC) of the U.S. Naval Observatory (USNO); and the use of the LORAN-C navigation system for maintaining the user's clock to a UTC scale is described. The atomic time scale and the UTC of several national laboratories and observatories relative to the international atomic time are reported. Typical performance of several NASA tracking station clocks, relative to the USNO master clock, is also presented

A potential anti-tumor herbal medicine, Corilagin, inhibits ovarian cancer cell growth through blocking the TGF-β signaling pathways

BACKGROUND: Phyllanthus niruri L. is a well-known hepatoprotective and antiviral medicinal herb. Recently, we identified Corilagin as a major active component with anti-tumor activity in this herbal medicine. Corilagin is a member of the tannin family that has been discovered in many medicinal plants and has been used as an anti-inflammatory agent. However, there have been few reports of the anti-tumor effects of Corilagin, and its anti-tumor mechanism has not been investigated clearly. The aim of the present study is to investigate the anticancer properties of Corilagin in ovarian cancer cells. METHODS: The ovarian cancer cell lines SKOv3ip, Hey and HO-8910PM were treated with Corilagin and analyzed by Sulforhodamine B (SRB) cell proliferation assay, flow cytometry, and reverse phase protein array (RPPA). Corilagin was delivered intraperitoneally to mice bearing SKOv3ip xenografts. RESULTS: Corilagin inhibited the growth of the ovarian cancer cell lines SKOv3ip and Hey, with IC50 values of less than 30 μM, while displaying low toxicity against normal ovarian surface epithelium cells, with IC50 values of approximately 160 μM. Corilagin induced cell cycle arrest at the G2/M stage and enhanced apoptosis in ovarian cancer cells. Immunoblotting assays demonstrated that Cyclin B1, Myt1, Phospho-cdc2 and Phospho-Weel were down-regulated after Corilagin treatment. Xenograft tumor growth was significantly lower in the Corilagin-treated group compared with the untreated control group (P <0.05). More interestingly, Corilagin inhibited TGF-β secretion into the culture supernatant of all tested ovarian cancer cell lines and blocked the TGF-β-induced stabilization of Snail. In contrast, a reduction of TGF-β secretion was not observed in cancer cells treated with the cytotoxic drug Paclitaxel, suggesting that Corilagin specifically targets TGF-β secretion. Corilagin blocked the activation of both the canonical Smad and non-canonical ERK/AKT pathways. CONCLUSIONS: Corilagin extracted from Phyllanthus niruri L. acts as a natural, effective therapeutic agent against the growth of ovarian cancer cells via targeted action against the TGF-β/AKT/ERK/Smad signaling pathways

State College Times, November 24, 1933

Volume 22, Issue 38https://scholarworks.sjsu.edu/spartandaily/12932/thumbnail.jp

Spartan Daily, March 5, 1963

Volume 50, Issue 80https://scholarworks.sjsu.edu/spartandaily/4427/thumbnail.jp

Spartan Daily, January 8, 1962

Volume 49, Issue 55https://scholarworks.sjsu.edu/spartandaily/4242/thumbnail.jp

(Super)conformal Symmetry Breaking

We argue that the only consistent way to break conformal invariance in a quantum theory of gravity is spontaneously in a finite locally conformal supersymmetric theory. This generically occurs whenever scalar fields are present. Covariant surface-integral expressions for the super-charge and four-momentum in terms of asymptotically constant spinor fields are derived. These are used to discuss stability and other aspects of the theory

Spartan Daily, March 4, 1953

Volume 41, Issue 102https://scholarworks.sjsu.edu/spartandaily/11849/thumbnail.jp