Optical Microring Resonators for Photoacoustic Imaging and Detection.

This work is to utilize the superior characteristics of polymer microring resonators in ultrasound detection to push the application of photoacoustic imaging to an entirely new level. We first demonstrated significantly improved imaging quality for photoacoustic tomography (PAT) using microring detectors. For wideband PAT, the microring detectors were able to faithfully detect both the boundaries and the inner structure, while piezoelectric detectors can only preserve one of the two aspects. For high-resolution PAT over a large imaging area, we imaged 50 µm black beads and found that microrings produced high-resolution imaging over a 16-mm-diameter imaging area while the 500 µm piezoelectric detectors only obtained high-resolution imaging over a small area around center. Pure optical photoacoustic microscopy (PAM) has been demonstrated. Microring ultrasonic resonators were applied in in vivo photoacoustic imaging for the first time. Good imaging signal-to-noise ratio and high axial resolution of 8 µm were calibrated. As a comparison, a commercial hydrophone with similar sensitivity produced a low axial resolution of 105 µm. A 5 mm miniaturized probe consisting of a fiber to deliver excitation laser pulses and microring detectors for ultrasound detection has been fabricated for photoacoustic endoscopy. The calibrated high radial resolution of 21 µm was higher than other types of endoscopic photoacoustic probes, around 40 µm or larger. A photoacoustic correlation spectroscopy (PACS) technique was proposed. In a proof-of-concept experiment, we demonstrated low-speed flow measurement of ~15 µm/s by the PACS technique. We also demonstrated in vivo flow speed measurement of red blood cells in capillaries in a chick embryo model by PACS. Other techniques might have difficulties to measure it due to the low signal contrast and/or poor resolutions. We also proposed terahertz electromagnetic pulse detection by photoacoustic method. We used carbon nanotube composites as efficient photoacoustic transmitters and microrings as sensitive detectors. The photoacoustic method provides low-cost and real-time terahertz detection (~µs), which is difficult by conventional terahertz detectors, such as a bolometer or a pyroelectric detector.Ph.D.Electrical EngineeringUniversity of Michigan, Horace H. Rackham School of Graduate Studieshttp://deepblue.lib.umich.edu/bitstream/2027.42/91497/1/chensll_1.pd

Harnessing optical micro-combs for microwave photonics

In the past decade, optical frequency combs generated by high-Q micro-resonators, or micro-combs, which feature compact device footprints, high energy efficiency, and high-repetition-rates in broad optical bandwidths, have led to a revolution in a wide range of fields including metrology, mode-locked lasers, telecommunications, RF photonics, spectroscopy, sensing, and quantum optics. Among these, an application that has attracted great interest is the use of micro-combs for RF photonics, where they offer enhanced functionalities as well as reduced size and power consumption over other approaches. This article reviews the recent advances in this emerging field. We provide an overview of the main achievements that have been obtained to date, and highlight the strong potential of micro-combs for RF photonics applications. We also discuss some of the open challenges and limitations that need to be met for practical applications.Comment: 32 Pages, 13 Figures, 172 Reference

Photonic molecules and spectral engineering

This chapter reviews the fundamental optical properties and applications of pho-tonic molecules (PMs) - photonic structures formed by electromagnetic coupling of two or more optical microcavities (photonic atoms). Controllable interaction between light and matter in photonic atoms can be further modified and en-hanced by the manipulation of their mutual coupling. Mechanical and optical tunability of PMs not only adds new functionalities to microcavity-based optical components but also paves the way for their use as testbeds for the exploration of novel physical regimes in atomic physics and quantum optics. Theoretical studies carried on for over a decade yielded novel PM designs that make possible lowering thresholds of semiconductor microlasers, producing directional light emission, achieving optically-induced transparency, and enhancing sensitivity of microcavity-based bio-, stress- and rotation-sensors. Recent advances in material science and nano-fabrication techniques make possible the realization of optimally-tuned PMs for cavity quantum electrodynamic experiments, classical and quantum information processing, and sensing.Comment: A review book chapter: 29 pages, 19 figure

Silicon-Based Integrated Label-Free Optofluidic Biosensors: Latest Advances and Roadmap

By virtue of the well-developed micro- and nanofabrication technologies and rapidly progressing surface functionalization strategies, silicon-based devices have been widely recognized as a highly promising platform for the next-generation lab-on-a-chip bioanalytical systems with a great potential for point-of-care medical diagnostics. Herein, an overview of the latest advances in silicon-based integrated optofluidic label-free biosensing technologies relying on the efficient interactions between the evanescent light field at the functionalized surface and specifically bound analytes is presented. State-of-the-art technologies demonstrating label-free evanescent wave-based biomarker detection mainly encompass three device configurations, including on-chip waveguide-based interferometers, microring resonators, and photonic-crystal-based cavities. Moreover, up-to-date strategies for elevating the sensitivities and also simplifying the sensing processes are discussed. Emerging laboratory prototypes with advanced integration and packaging schemes incorporating automatic microfluidic components or on-chip optoelectronic devices lead to one significant step forward in real applications of decentralized diagnostics. Besides, particular attention is paid to currently commercialized label-free optical bioanalytical models on the market. Finally, the prospects are elaborated with several research routes toward chip-scale, low-cost, highly sensitive, multi-functional, and user-friendly bioanalytical systems benefiting to global healthcare. © 2020 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinhei

Real-time label-free biosensing with integrated planar waveguide ring resonators

We review the use of planar integrated optical waveguide ring resonators for label free bio-sensing and present recent results from two European biosensor collaborations: SABIO and InTopSens. Planar waveguide ring resonators are attractive for label-free biosensing due to their small footprint, high Q-factors, and compatibility with on-chip optics and microfluidics. This enables integrated sensor arrays for compact labs-on-chip. One application of label-free sensor arrays is for point-of-care medical diagnostics. Bringing such powerful tools to the single medical practitioner is an important step towards personalized medicine, but requires addressing a number of issues: improving limit of detection, managing the influence of temperature, parallelization of the measurement for higher throughput and on-chip referencing, efficient light-coupling strategies to simplify alignment, and packaging of the optical chip and integration with microfluidics. From the SABIO project we report refractive index measurement and label-free biosensing in an 8-channel slotwaveguide ring resonator sensor array, within a compact cartridge with integrated microfluidics. The sensors show a volume sensing detection limit of 5 × 10-6 RIU and a surface sensing detection limit of 0.9 pg/mm2. From the InTopSens project we report early results on silicon-on-insulator racetrack resonators

Variation-Aware Modeling and Design of Nanophotonic Interconnects

Optical interconnects have started to replace electrical interconnects in the communications between racks and circuit boards with potential benefits in bandwidth, delay, power efficiency, and crosstalk. Silicon photonics has emerged to be a highly promising enabling technology for the short-reach nanophotonic interconnects because it offers favorable CMOS compatibility and high integration level. The fast-growing complexity of photonic integrated circuit (PIC) and close electro-optical integration call for computer-aided design (CAD) for integrated photonics, and electronic-photonic design automation (EPDA) including accurate behavior models and efficient simulation methodologies for integrated electro-optical systems. Also, the nanophotonic devices are highly sensitive to fabrication process variation and thermal variation effects, which requires proper modeling, optimization, and management schemes. To address these problems, this thesis is dedicated to the following two tasks: (1) compact modeling and circuit-level simulation of nanophotonic interconnects, and (2) power-efficient management of the variation effects in nanophotonic interconnects.The first part of the thesis develops compact models for key components in nanophotonic interconnects including silicon microring modulators, diode lasers, electro-absorption modulators (EAM), photodetectors, etc. These compact models are developed based on their electrical and optical properties, and are then extensively validated by measurement data. The model parameters are extracted from common electrical and optical tests. Implemented in Verilog-A, the models are used in SPICE simulations of optical links, whose results again agree well with measurement data. The compact model library and the simulation methodology enable electro-optical co-simulations and optical device design explorations in the circuit-level.In the second part of the thesis, we propose modeling methods and power-efficient management schemes for the process and thermal variations in optical interconnects. The proposed adaptive tuning technique performs on-chip self-tests and adaptively allocates just enough power for link operations. The technique saves significant amount of power compared to worst-case based conservative designs, and scales well w.r.t. variations and network size. We also design power-efficient pairing algorithms for microring-based optical interconnects. Our algorithms optimally mix-and-match microring-based devices to minimize the power consumption for tuning. The algorithms are tested on both measured and synthetic data sets, demonstrating promising results of power reduction and scalability for handling a large number of devices. Lastly, we decompose and analyze wafer-scale spatial patterns of process variations in microring modulators. We further investigate the correlations between the spatial patterns and fabrication process steps, which is valuable for understanding process variation sources and improving fabrication processes for uniformity