Schubert Polynomials and Classes of Hessenberg Varieties

Regular semisimple Hessenberg varieties are a family of subvarieties of the flag variety that arise in number theory, numerical analysis, representation theory, algebraic geometry, and combinatorics. We give a Giambelli formula expressing the classes of regular semisimple Hessenberg varieties in terms of Chern classes. In fact, we show that the cohomology class of each regular semisimple Hessenberg variety is the specialization of a certain double Schubert polynomial, giving a natural geometric interpretation to such specializations. We also decompose such classes in terms of the Schubert basis for the cohomology ring of the flag variety. The coefficients obtained are nonnegative, and we give closed combinatorial formulas for the coefficients in many cases. We introduce a closely related family of schemes called regular nilpotent Hessenberg schemes, and use our results to determine when such schemes are reduced

Neuronal alterations in chronic cerebral Toxoplasma gondii infection

Magdeburg, Univ., Fak. für Naturwiss., Diss., 2015von Alexandru Parlo

Studying Glutamatergic Gliotransmission as a Functional Model to Assess Physio-Pathological Conditions and Receptor Cross-Talk

SUMMARY This thesis is divided into two parts; in the first part, we characterized the effect of acute stress on the astrocytic glutamate release in the prefrontal cortex of rat brain. In the second part, we evaluate the interaction of the Oxytocin receptor (OXTR) with both Adenosine receptor A2A and Dopamine D2 receptors in the brain striatum of male rats. First Part: Stress is known to disturb the physiological homeostasis of the body (McEwen et al., 2000). The number of studies demonstrated that stress leads to damage the prefrontal cortex the brain and results in the modulation in the secretion of various neurotransmitters (Karats Oreos and McEwen, 2011, Sousa and Almeida, 2012). Stress was recognized as a predominant risk factor for many diseases, together with cardiovascular, metabolic, and neuropsychiatric diseases. Among the latter, stress interacts with the variable genetic background of vulnerability in the pathogenesis of mood anxiety disorder (Laura et al., 2010). It may be acute or chronic, can involve neuropsychiatric components such as stress, depression, mood, and anxiety (Laura et al., 207) and produces many behavioral and neurochemical changes, as determined in human (De Kloet et al., 2005, Kim & Diamond 2002). Studies in the literature truly indicated that acute stress have an effect on glutamatergic neurotransmission in the prefrontal cortex, inducing changes in glutamate release, receptor and glutamate clearance and metabolism (Popoli et al., 2012: Licznerski and Duman 3013). The effects of acute footshock stress on glutamate release and transmission were still unknown. In this study, we investigated the release of glutamate from astrocytes. The analyses have been performed in the prefrontal cortex (PFC) at different time intervals straight away after 40 min of stress and 6 and 24 hours after stress start, to monitor the early and delayed effects of acute stress on glutamate release. After the acute stress, animals were subjected to sucrose test to distinguish vulnerable and resilient rats. Second Part: There has been a growing interest in the investigation of the role of astrocytes in neurodegenerative and neuropsychiatric diseases and their complex neuron-astrocytes network function. The receptor\u2013receptor interactions (RRI) can have an important function in the signalling transduction pathways. A previous well established study evaluate the interactions between the G-protein coupled receptors of adenosine A2A receptors (A2A) and dopamine D2 receptors (D2) in several experimental models (Ferr\ue9 et al., 2008), while it\u2019s barely investigated in astrocytes. Growing evidence shows that adult striatal astrocytes largely express both D2 and A2A receptors (Cervetto et at., 2017). Moreover, the presence of A2A-D2 heteroreceptor complexes has led to a new perspective of molecular mechanisms involved in Parkinson\u2019s disease (PD), providing novel drug targets. Therefore in the present study, we investigate the physical and functional interactions of A2A and D2 with another G protein-coupled receptors i.e. OXTR in astrocytes processes from adult rat striatum. We also evaluate the effect of this interaction on the astrocytic glutamate release in rat striatum

Oil Spaces

Oil Spaces traces petroleum’s impact through a range of territories from across the world, showing how industrially drilled petroleum and its refined products have played a major role in transforming the built environment in ways that are often not visible or recognized. Over the past century and a half, industrially drilled petroleum has powered factories, built cities, and sustained nation-states. It has fueled ways of life and visions of progress, modernity, and disaster. In detailed international case studies, the contributors consider petroleum’s role in the built environment and the imagination. They study how petroleum and its infrastructure have served as a source of military conflict and political and economic power, inspiring efforts to create territories and reshape geographies and national boundaries. The authors trace ruptures and continuities between colonial and postcolonial frameworks, in locations as diverse as Sumatra, northeast China, Brazil, Nigeria, Tanzania, and Kuwait as well as heritage sites including former power stations in Italy and the port of Dunkirk, once a prime gateway through which petroleum entered Europe. By revealing petroleum’s role in organizing and imagining space globally, this book takes up a key task in imagining the possibilities of a post-oil future. It will be invaluable reading to scholars and students of architectural and urban history, planning, and geography of sustainable urban environments