CVD nano-coating of carbon composites for space materials atomic oxygen shielding

The present work analyzes the possibility to employ carbon nanostructures as a basic material to prevent the erosion effects of atomic oxygen suffered by the carbon fiber reinforced polymeric material used in low earth orbit space environment. The application of thin protecting coatings to base materials is a widely used method for preventing the atomic oxygen induced erosion, and thus degradation. The generic purpose is to integrate carbon nanostructures onto carbon composites surface in order to develop the basic substrate of advanced nanocomposite for atomic oxygen protection. The final goal is the characterization of carbon nanostructures-reinforced carbon composites by means of on-ground atomic oxygen simulation facility, with the future objective to assess and optimize the process of carbon-multiscale advanced composites production. With such an aim, a wide investigation on the methane chemical vapor deposition (CVD) over catalyzed carbon fiber-based substrates has been carried out. The as grown nanostructures have been analyzed in terms of morphology, as well as regarding the main features of the resulting growth (yield, purity, homogeneity, coating uniformity, etc.) and the influence of the deposition route operating parameters (catalyst typology, gas flowing rate, growth time/temperature, etc.). A high degree of reproducibility in terms of the relationship between the carbon deposit type/yield and the main process variables (catalyst and protocol) has been thus obtained. Finally, atomic oxygen ground tests have been conducted in order to evaluate the coating process effectiveness. The on-ground test in atomic oxygen environment, with respect to the performances of the reference carbon composites (in terms of total mass loss and atomic oxygen rate of erosion), showed a worsening for the disordered carbon deposit, while an intriguing improvement was achieved by the high-yield carbon nano-filaments deposition

Global impacts of land degradation

Study commissioned by the Scientific, Technical and Advisory Panel (STAP) of the Global Environment Facility (GEF) to support the development of the new GEF focal area of Land Degradatio

A Pilot Stability Study of Dehydroepiandrosterone Rapid-dissolving Tablets Prepared by Extemporaneous Compounding

Dehydroepiandrosterone supplementation is used to treat a variety of conditions. Rapid-dissolving tablets are a relatively novel choice for compounded dehydroepiandrosterone dosage forms. While rapid-dissolving tablets offer ease of administration, there are uncertainties about the physical and chemical stability of the drug and dosage form during preparation and over long-term storage. This study was designed to evaluate the stability of dehydroepiandrosterone rapid-dissolving tablets just after preparation and over six months of storage. The Professional Compounding Centers of America rapid-dissolving tablet mold and base formula were used to prepare 10-mg strength dehydroepiandrosterone rapid-dissolving tablets. The formulation was heated at 100°C to 110°C for 30 minutes, released from the mold, and cooled at room temperature for 30 minutes. The resulting rapid-dissolving tablets were individually packaged in amber blister packs and stored in a stability chamber maintained at 25°C and 60% relative humidity. The stability samples were pulled at pre-determined time points for evaluation, which included visual inspection, tablet weight check, United States Pharmacopeia disintegration test, and stability-indicating high-performance liquid chromatography. The freshly prepared dehydroepiandrosterone rapiddissolving tablets exhibited satisfactory chemical and physical stability. Time 0 samples disintegrated within 40 seconds in water kept at 37°C. The highperformance liquid chromatographic results confirmed that the initial potency was 101.9% of label claim and that there was no chemical degradation from the heating procedure. Over six months of storage, there were no significant changes in visual appearance, physical integrity, or disintegration time for any of the stability samples. The high-performance liquid chromatographic results also indicated that dehydroepiandrosterone rapid-dissolving tablets retained \u3e95% label claim with no detectable degradation products. The dehydroepiandrosterone rapid-dissolving tablets investigated in this pilot study were physically and chemically stable during preparation and over six months of storage at 25°C and 60% relative humidity

An artificial intelligence-based structural health monitoring system for aging aircraft

To reduce operating expenses, airlines are now using the existing fleets of commercial aircraft well beyond their originally anticipated service lives. The repair and maintenance of these 'aging aircraft' has therefore become a critical safety issue, both to the airlines and the Federal Aviation Administration. This paper presents the results of an innovative research program to develop a structural monitoring system that will be used to evaluate the integrity of in-service aerospace structural components. Currently in the final phase of its development, this monitoring system will indicate when repair or maintenance of a damaged structural component is necessary

RFRP3 influences basal lamina degradation, cellular death, and progesterone secretion in cultured preantral ovarian follicles from the domestic cat.

The hypothalamic neuropeptide RFRP3 can suppress hypothalamic GnRH neuron activation and inhibit gonadotropin release from the anterior pituitary. RFRP3 is also produced locally in the ovary and can inhibit steroidogenesis and follicle development in many vertebrates. However, almost nothing is known about the presence and regulatory action of RFRP3 in gonads of any carnivore species. Such knowledge is important for developing captive breeding programs for endangered carnivores and for inhibiting reproduction in feral species. Using the domestic cat as a model, our objectives were to (1) demonstrate the expression of feline RFRP3 (fRFRP3) and its receptor in the cat ovary and (2) assess the influence of fRFRP3 on ovarian follicle integrity, survival, and steroidogenesis in vitro. We first confirmed that fRFRP3 and its receptors (NPFFR1 and NPFFR2) were expressed in cat ovaries by sequencing PCR products from ovarian RNA. We then isolated and cultured preantral ovarian follicles in the presence of 10 or 1 µM fRFRP3 + FSH (1 µg/mL). We recorded the percentage of morphologically viable follicles (basal lamina integrity) over 8 days and calculated percentage survival of follicles on Day 8 (using fluorescent markers for cell survival and death). Last, we quantified progesterone accumulation in media. 10 µM fRFRP3 had no observable effect on viability, survival, or steroid production compared to follicles exposed to only FSH. However, 1 µM fRFRP3 decreased the percentage of morphologically viable follicles and the percentage of surviving follicles on Day 8. At the same time, 1 µM fRFRP3 increased the accumulation of progesterone in media. Our study shows, for the first time, direct action of RFRP3 on the follicle as a functional unit, and it is the first in a carnivore species. More broadly, our results support a conserved, inhibitory action of RFRP3 on ovarian follicle development and underscore the importance of comparative functional studies

Facilitating the driver detection of road surface type by selective manipulation of the steering-wheel acceleration signal

Copyright @ 2012 by Institution of Mechanical Engineers.Previous research has investigated the possibility of facilitating the driver detection of road surface type by means of selective manipulation of the steering-wheel acceleration signal. In previous studies a selective increase in acceleration amplitude has been found to facilitate road-surface-type detection, as has selective manipulation of the individual transient events which are present in the signal. The previous research results have been collected into a first guideline for the optimization of the steering-wheel acceleration signal, and the guideline has been tested in the current study. The test stimuli used in the current study were ten steering-wheel acceleration-time histories which were selected from an extensive database of road test measurements performed by the research group. The time histories, which were all from midsized European automobiles and European roads, were selected such that the widest possible operating envelope could be achieved in terms of the r.m.s. value of the steering acceleration, the kurtosis, the power spectral density function, and the number of transient events present in the signal. The time histories were manipulated by means of the mildly non-stationary mission synthesis algorithm in order to increase, by a factor of 2, both the number and the size of the transient events contained within the frequency interval from 20 Hz to 60Hz. The ensemble, composed of both the unmanipulated and the manipulated time histories, was used to perform a laboratory-based detection task with 15 participants, who were presented the individual stimuli in random order. The participants were asked to state, by answering 'yes' or 'no', whether each stimulus was considered to be from the road surface that was displayed in front of them by means of a large photograph on a board. The results suggest that the selectively manipulated steering-wheel acceleration stimuli produced improved detection for eight of the ten road surface types which were tested, with a maximum improvement of 14 per cent in the case of the broken road surface. The selective manipulation did lead, however, to some degradation in detection for the motorway road stimulus and for the noise road stimulus, thus suggesting that the current guideline is not universally optimal for all road surfaces

A Survey on Wireless Security: Technical Challenges, Recent Advances and Future Trends

This paper examines the security vulnerabilities and threats imposed by the inherent open nature of wireless communications and to devise efficient defense mechanisms for improving the wireless network security. We first summarize the security requirements of wireless networks, including their authenticity, confidentiality, integrity and availability issues. Next, a comprehensive overview of security attacks encountered in wireless networks is presented in view of the network protocol architecture, where the potential security threats are discussed at each protocol layer. We also provide a survey of the existing security protocols and algorithms that are adopted in the existing wireless network standards, such as the Bluetooth, Wi-Fi, WiMAX, and the long-term evolution (LTE) systems. Then, we discuss the state-of-the-art in physical-layer security, which is an emerging technique of securing the open communications environment against eavesdropping attacks at the physical layer. We also introduce the family of various jamming attacks and their counter-measures, including the constant jammer, intermittent jammer, reactive jammer, adaptive jammer and intelligent jammer. Additionally, we discuss the integration of physical-layer security into existing authentication and cryptography mechanisms for further securing wireless networks. Finally, some technical challenges which remain unresolved at the time of writing are summarized and the future trends in wireless security are discussed.Comment: 36 pages. Accepted to Appear in Proceedings of the IEEE, 201

Urban Watershed/Water Body Restoration - The Driving Forces

Urban streams are used for several purposes. Some uses are conflicting and some are complementary. The use of urban water bodies and the resolution of conflicts is driven by anthropogenic and biocentric/ecocentric interests that must be optimized and the conflicts resolved. This article examines and analyzes land ethics (biocentric) and socio-economic (anthropocentric) drives for stream restoration of urban watersheds located in the Milwaukee (WI) metropolitan area. The basins experienced increased flooding, significant degradation of sediment and water quality, and loss of aquatic species, all due to urbanization. It was found that the primary drivers for restoration of urban streams are the ethical attitudes of population towards the ecocentric benefits of restoration in combination with a desire for flood control. A Contingent Valuation Survey of citizens residing in two Milwaukee watersheds revealed that those who see the watershed in ecocentric terms appear to have a greater Willingness to Pay for watershed/water body improvements than those who see the benefits solely in anthropogenic terms of reduction of flood damages

Genome-wide identification of FoxO-dependent gene networks in skeletal muscle during C26 cancer cachexia

BACKGROUND: Evidence from cachectic cancer patients and animal models of cancer cachexia supports the involvement of Forkhead box O (FoxO) transcription factors in driving cancer-induced skeletal muscle wasting. However, the genome-wide gene networks and associated biological processes regulated by FoxO during cancer cachexia are unknown. We hypothesize that FoxO is a central upstream regulator of diverse gene networks in skeletal muscle during cancer that may act coordinately to promote the wasting phenotype. METHODS: To inhibit endogenous FoxO DNA-binding, we transduced limb and diaphragm muscles of mice with AAV9 containing the cDNA for a dominant negative (d.n.) FoxO protein (or GFP control). The d.n.FoxO construct consists of only the FoxO3a DNA-binding domain that is highly homologous to that of FoxO1 and FoxO4, and which outcompetes and blocks endogenous FoxO DNA binding. Mice were subsequently inoculated with Colon-26 (C26) cells and muscles harvested 26 days later. RESULTS: Blocking FoxO prevented C26-induced muscle fiber atrophy of both locomotor muscles and the diaphragm and significantly spared force deficits. This sparing of muscle size and function was associated with the differential regulation of 543 transcripts (out of 2,093) which changed in response to C26. Bioinformatics analysis of upregulated gene transcripts that required FoxO revealed enrichment of the proteasome, AP-1 and IL-6 pathways, and included several atrophy-related transcription factors, including Stat3, Fos, and Cebpb. FoxO was also necessary for the cancer-induced downregulation of several gene transcripts that were enriched for extracellular matrix and sarcomere protein-encoding genes. We validated these findings in limb muscles and the diaphragm through qRT-PCR, and further demonstrate that FoxO1 and/or FoxO3a are sufficient to increase Stat3, Fos, Cebpb, and the C/EBPβ target gene, Ubr2. Analysis of the Cebpb proximal promoter revealed two bona fide FoxO binding elements, which we further establish are necessary for Cebpb promoter activation in response to IL-6, a predominant cytokine in the C26 cancer model. CONCLUSIONS: These findings provide new evidence that FoxO-dependent transcription is a central node controlling diverse gene networks in skeletal muscle during cancer cachexia, and identifies novel candidate genes and networks for further investigation as causative factors in cancer-induced wasting.R01 AR060217 - NIAMS NIH HHS; R01 AR060209 - NIAMS NIH HHS; T32 HD043730 - NICHD NIH HHS; R00 HL098453 - NHLBI NIH HHS; R00HL098453 - NHLBI NIH HHS; R01AR060209 - NIAMS NIH HHS; R01AR060217 - NIAMS NIH HH